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UBE2I ubiquitin conjugating enzyme E2 I [ Homo sapiens (human) ]

Gene ID: 7329, updated on 17-Mar-2024

Summary

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Official Symbol
UBE2Iprovided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 Iprovided by HGNC
Primary source
HGNC:HGNC:12485
See related
Ensembl:ENSG00000103275 MIM:601661; AllianceGenome:HGNC:12485
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P18; UBC9; C358B7.1
Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 23.2), endometrium (RPKM 17.8) and 25 other tissues See more
Orthologs
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Genomic context

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See UBE2I in Genome Data Viewer
Location:
16p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (1309152..1327017)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (1325332..1343194)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1359153..1377018)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1335831-1336425 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10217 Neighboring gene tryptase pseudogene 2 Neighboring gene uncharacterized LOC124903624 Neighboring gene MPRA-validated peak2468 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6965 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6966 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10218 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6968 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6969 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:1360147-1360758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10219 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10220 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10221 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:1382600-1382800 Neighboring gene ribosomal protein S20 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6970 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1388370-1389219 Neighboring gene BAI1 associated protein 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1392110-1392658 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10222 Neighboring gene TSR3 ribosome maturation factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Combined Evaluation of mRNA and Protein Expression, Promoter Methylation, and Immune Infiltration of UBE2I in Pan-Digestive System Tumors. Huang S, et al. Oxid Med Cell Longev, 2022. PMID 36193060, Free PMC Article
  2. UBC9 coordinates inflammation affecting development of bladder cancer. Huang X, et al. Sci Rep, 2020 Nov 26. PMID 33244139, Free PMC Article
  3. HRM screening of the UBC9 gene encoding the SUMO-E2-conjugating enzyme - case-control study in breast cancer. Bialik P, et al. Exp Oncol, 2020 Jun. PMID 32602284
  4. Ubc9 Interacts with and SUMOylates the TCR Adaptor SLP-76 for NFAT Transcription in T Cells. Xiong Y, et al. J Immunol, 2019 Dec 1. PMID 31666306
  5. Nuclear accumulation of UBC9 contributes to SUMOylation of lamin A/C and nucleophagy in response to DNA damage. Li Y, et al. J Exp Clin Cancer Res, 2019 Feb 11. PMID 30744690, Free PMC Article

See all (576) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Repression of the SUMO-conjugating enzyme UBC9 is associated with lowered double minutes and reduced tumor progression.
    Title: Repression of the SUMO-conjugating enzyme UBC9 is associated with lowered double minutes and reduced tumor progression.
  2. The Interaction between SARS-CoV-2 Nucleocapsid Protein and UBC9 Inhibits MAVS Ubiquitination by Enhancing Its SUMOylation.
    Title: The Interaction between SARS-CoV-2 Nucleocapsid Protein and UBC9 Inhibits MAVS Ubiquitination by Enhancing Its SUMOylation.
  3. Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells.
    Title: Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells.
  4. Knockdown of UBE2I inhibits tumorigenesis and enhances chemosensitivity of cholangiocarcinoma via modulating p27kip1 nuclear export.
    Title: Knockdown of UBE2I inhibits tumorigenesis and enhances chemosensitivity of cholangiocarcinoma via modulating p27kip1 nuclear export.
  5. Upregulation of miRNA-10a-5p promotes tumor progression in cervical cancer by suppressing UBE2I signaling.
    Title: Upregulation of miRNA-10a-5p promotes tumor progression in cervical cancer by suppressing UBE2I signaling.
  6. Combined Evaluation of mRNA and Protein Expression, Promoter Methylation, and Immune Infiltration of UBE2I in Pan-Digestive System Tumors.
    Title: Combined Evaluation of mRNA and Protein Expression, Promoter Methylation, and Immune Infiltration of UBE2I in Pan-Digestive System Tumors.
  7. SUMOylation stabilizes hSSB1 and enhances the recruitment of NBS1 to DNA damage sites.
    Title: SUMOylation stabilizes hSSB1 and enhances the recruitment of NBS1 to DNA damage sites.
  8. Adipose-specific knockout of ubiquitin-conjugating enzyme E2L6 (Ube2l6) reduces diet-induced obesity, insulin resistance, and hepatic steatosis.
    Title: Adipose-specific knockout of ubiquitin-conjugating enzyme E2L6 (Ube2l6) reduces diet-induced obesity, insulin resistance, and hepatic steatosis.
  9. HRM screening of the UBC9 gene encoding the SUMO-E2-conjugating enzyme - case-control study in breast cancer.
    Title: HRM screening of the UBC9 gene encoding the SUMO-E2-conjugating enzyme - case-control study in breast cancer.
  10. UBC9 coordinates inflammation affecting development of bladder cancer.
    Title: UBC9 coordinates inflammation affecting development of bladder cancer.
Submit: New GeneRIF Correction See all GeneRIFs (125)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Levels of HIV-1 gp120 and Endo Hf-resistant gp120 are reduced in the absence of UBC9 expression. Degradation of gp120 occurs before transport to the plasma membrane and the lipid rafts in the UBC9 knockdown cells PubMed
env UBC9 contributes to viral glycoproteins gp120/gp41 stability in the presence of Gag expression and affects incorporation of the gp120/gp41 into virions PubMed
Envelope transmembrane glycoprotein gp41 env UBC9 contributes to viral glycoproteins gp120/gp41 stability in the presence of Gag expression and affects incorporation of the gp120/gp41 into released virions PubMed
Pr55(Gag) gag HIV-1 Gag trafficking and association with the plasma membrane is altered in the absebce of UBC9 PubMed
gag UBC9 contributes to viral glycoproteins gp120/gp41 stability in the presence of Gag expression and affects incorporation of the gp120/gp41 into released virions PubMed
gag Disrupting the function of KIF4 leads Gag transient accumulation in discrete, perinuclear, nonendocytic clusters that co-localize with endogenous KIF4, Ubc9, and SUMO PubMed
gag Coimmunoprecipitation shows that HIV-1 Gag and human UBC9 interact in vivo. HIV-1 Gag and human UBC9 colocalize in HIV-1-expressing cells PubMed
integrase gag-pol HIV-1 IN interacts with SUMO1/SUMO2 and Ubc9 in cells. Upregulations of SUMO1/SUMO2 and Ubc9 inhibit HIV-1 integration, while downregulations of SUMO1/SUMO2 and Ubc9 increase HIV-1 integration PubMed
p6 gag HIV-1 p6 interacts with Ubc9 in a yeast two-hybrid system PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RING-like zinc finger domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables RNA binding HDA PubMed 
enables SUMO conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SUMO conjugating enzyme activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables SUMO transferase activity EXP
Inferred from Experiment
more info
 PubMed 
enables SUMO transferase activity TAS
Traceable Author Statement
more info
  
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small protein activating enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic nuclear membrane reassembly TAS
Traceable Author Statement
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
  
involved_in nuclear export EXP
Inferred from Experiment
more info
 PubMed 
involved_in positive regulation of SUMO transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein modification process TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein sumoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein sumoylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein sumoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein sumoylation TAS
Traceable Author Statement
more info
  
involved_in ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in PML body IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SUMO ligase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nuclear envelope TAS
Traceable Author Statement
more info
  
part_of nuclear pore NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in synaptonemal complex TAS
Traceable Author Statement
more info
 PubMed 
part_of transferase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
SUMO-conjugating enzyme UBC9
Names
RING-type E3 SUMO transferase UBC9
SUMO-1-protein ligase
SUMO-protein ligase
ubiquitin carrier protein 9
ubiquitin carrier protein I
ubiquitin conjugating enzyme 9
ubiquitin conjugating enzyme E2I
ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)
ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9)
ubiquitin-conjugating enzyme UbcE2A
ubiquitin-like protein SUMO-1 conjugating enzyme
ubiquitin-protein ligase E2I
ubiquitin-protein ligase I
NP_003336.1
NP_919235.1
NP_919236.1
NP_919237.1
XP_005255597.1
XP_011520946.1
XP_011520947.1
XP_047290540.1
XP_047290541.1
XP_054169802.1
XP_054169803.1
XP_054169804.1
XP_054169805.1
XP_054169806.1
XP_054169807.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003345.5 → NP_003336.1  SUMO-conjugating enzyme UBC9

    See identical proteins and their annotated locations for NP_003336.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK291118, AL031714, BC000427, BI793063
    Consensus CDS
    CCDS10433.1
    UniProtKB/Swiss-Prot
    D3DU69, P50550, P63279, Q15698, Q59GX1, Q86VB3
    UniProtKB/TrEMBL
    A8K503
    Related
    ENSP00000380649.3, ENST00000397514.8
    Conserved Domains (1) summary
    pfam00179
    Location:8 → 152
    UQ_con; Ubiquitin-conjugating enzyme

  2. NM_194259.3 → NP_919235.1  SUMO-conjugating enzyme UBC9

    See identical proteins and their annotated locations for NP_919235.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an additional exon in the 5' UTR, as compared to variant 1.
    Source sequence(s)
    AK291118, AL031714, BF315618, BI793063, D45050
    Consensus CDS
    CCDS10433.1
    UniProtKB/Swiss-Prot
    D3DU69, P50550, P63279, Q15698, Q59GX1, Q86VB3
    UniProtKB/TrEMBL
    A8K503
    Related
    ENSP00000380650.2, ENST00000397515.7
    Conserved Domains (1) summary
    pfam00179
    Location:8 → 152
    UQ_con; Ubiquitin-conjugating enzyme

  3. NM_194260.3 → NP_919236.1  SUMO-conjugating enzyme UBC9

    See identical proteins and their annotated locations for NP_919236.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, as compared to variant 1.
    Source sequence(s)
    AC120498, AL031714, BI793063, CX788607
    Consensus CDS
    CCDS10433.1
    UniProtKB/Swiss-Prot
    D3DU69, P50550, P63279, Q15698, Q59GX1, Q86VB3
    UniProtKB/TrEMBL
    A8K503
    Related
    ENSP00000348056.4, ENST00000355803.9
    Conserved Domains (1) summary
    pfam00179
    Location:8 → 152
    UQ_con; Ubiquitin-conjugating enzyme

  4. NM_194261.3 → NP_919237.1  SUMO-conjugating enzyme UBC9

    See identical proteins and their annotated locations for NP_919237.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, as compared to variant 1.
    Source sequence(s)
    AB208988, AC120498, AL031714, BI793063
    Consensus CDS
    CCDS10433.1
    UniProtKB/Swiss-Prot
    D3DU69, P50550, P63279, Q15698, Q59GX1, Q86VB3
    UniProtKB/TrEMBL
    A8K503
    Related
    ENSP00000324897.5, ENST00000325437.10
    Conserved Domains (1) summary
    pfam00179
    Location:8 → 152
    UQ_con; Ubiquitin-conjugating enzyme

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    1309152..1327017
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434585.1 → XP_047290541.1  SUMO-conjugating enzyme UBC9 isoform X1

    UniProtKB/TrEMBL
    B0QYN7

  2. XM_011522645.2 → XP_011520947.1  SUMO-conjugating enzyme UBC9 isoform X1

    See identical proteins and their annotated locations for XP_011520947.1

    UniProtKB/TrEMBL
    B0QYN7
    Conserved Domains (2) summary
    COG5078
    Location:1 → 137
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00179
    Location:8 → 137
    UQ_con; Ubiquitin-conjugating enzyme

  3. XM_047434584.1 → XP_047290540.1  SUMO-conjugating enzyme UBC9 isoform X1

    UniProtKB/TrEMBL
    B0QYN7

  4. XM_011522644.3 → XP_011520946.1  SUMO-conjugating enzyme UBC9 isoform X1

    See identical proteins and their annotated locations for XP_011520946.1

    UniProtKB/TrEMBL
    B0QYN7
    Conserved Domains (2) summary
    COG5078
    Location:1 → 137
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00179
    Location:8 → 137
    UQ_con; Ubiquitin-conjugating enzyme

  5. XM_005255540.3 → XP_005255597.1  SUMO-conjugating enzyme UBC9 isoform X1

    See identical proteins and their annotated locations for XP_005255597.1

    UniProtKB/TrEMBL
    B0QYN7
    Conserved Domains (2) summary
    COG5078
    Location:1 → 137
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00179
    Location:8 → 137
    UQ_con; Ubiquitin-conjugating enzyme

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    1325332..1343194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054313832.1 → XP_054169807.1  SUMO-conjugating enzyme UBC9 isoform X1

    UniProtKB/TrEMBL
    Q7KZS0

  2. XM_054313831.1 → XP_054169806.1  SUMO-conjugating enzyme UBC9 isoform X1

    UniProtKB/TrEMBL
    Q7KZS0

  3. XM_054313827.1 → XP_054169802.1  SUMO-conjugating enzyme UBC9 isoform X1

    UniProtKB/TrEMBL
    Q7KZS0

  4. XM_054313830.1 → XP_054169805.1  SUMO-conjugating enzyme UBC9 isoform X1

    UniProtKB/TrEMBL
    Q7KZS0

  5. XM_054313828.1 → XP_054169803.1  SUMO-conjugating enzyme UBC9 isoform X1

    UniProtKB/TrEMBL
    Q7KZS0

  6. XM_054313829.1 → XP_054169804.1  SUMO-conjugating enzyme UBC9 isoform X1

    UniProtKB/TrEMBL
    Q7KZS0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P63279.1 GenPept UniProtKB/Swiss-Prot:P63279

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