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Ppp2r2b protein phosphatase 2, regulatory subunit B, beta [ Mus musculus (house mouse) ]

Gene ID: 72930, updated on 16-Apr-2024

Summary

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Official Symbol
Ppp2r2bprovided by MGI
Official Full Name
protein phosphatase 2, regulatory subunit B, betaprovided by MGI
Primary source
MGI:MGI:1920180
See related
Ensembl:ENSMUSG00000024500 AllianceGenome:MGI:1920180
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SCA12; PR55-BETA; PP2A-PR55B; 2900026H06Rik; 6330404L05Rik; E130009M08Rik
Summary
Predicted to enable protein phosphatase regulator activity. Predicted to be involved in several processes, including mitochondrion organization; peptidyl-serine dephosphorylation; and positive regulation of neuron apoptotic process. Predicted to act upstream of or within apoptotic process. Predicted to be located in mitochondrial outer membrane. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol. Predicted to colocalize with cytoskeleton. Is expressed in several structures, including cranial ganglion; lung; sensory organ; tongue; and viscerocranium. Human ortholog(s) of this gene implicated in Alzheimer's disease; brain disease; breast cancer; and spinocerebellar ataxia type 12. Orthologous to human PPP2R2B (protein phosphatase 2 regulatory subunit Bbeta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 44.9), CNS E14 (RPKM 31.0) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Ppp2r2b in Genome Data Viewer
Location:
18 B3; 18 22.75 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (42777811..43192827, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (42645207..43059471, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C030004G16 gene Neighboring gene G protein-coupled receptor 151 Neighboring gene STARR-seq mESC enhancer starr_44444 Neighboring gene predicted gene, 41713 Neighboring gene STARR-seq mESC enhancer starr_44445 Neighboring gene STARR-seq mESC enhancer starr_44446 Neighboring gene predicted gene, 52345 Neighboring gene predicted gene, 22264 Neighboring gene predicted gene, 46622

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Protein phosphatase 2A B55β limits CD8+ T cell lifespan following cytokine withdrawal. Rodríguez-Rodríguez N, et al. J Clin Invest, 2020 Nov 2. PMID 32750040, Free PMC Article
  2. Deletion of a Neuronal Drp1 Activator Protects against Cerebral Ischemia. Flippo KH, et al. J Neurosci, 2020 Apr 8. PMID 32144179, Free PMC Article
  3. Morphine has an antinociceptive effect through activation of the okadaic-acid-sensitive Ser/Thr protein phosphatases PP 2 A and PP5 estimated by tail-pinch test in mice. Maeda T, et al. Brain Res, 2005 Sep 21. PMID 16102737
  4. Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye. Liu WB, et al. Mol Vis, 2008 Apr 21. PMID 18432318, Free PMC Article
  5. Akt-dependent Pp2a activity is required for epidermal barrier formation during late embryonic development. O'Shaughnessy RF, et al. Development, 2009 Oct. PMID 19762425, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bidirectional Transcription at the PPP2R2B Gene Locus in Spinocerebellar Ataxia Type 12.
    Title: Bidirectional Transcription at the PPP2R2B Gene Locus in Spinocerebellar Ataxia Type 12.
  2. Protein phosphatase 2A B55beta limits CD8+ T cell lifespan following cytokine withdrawal.
    Title: Protein phosphatase 2A B55β limits CD8+ T cell lifespan following cytokine withdrawal.
  3. PP-2A is less abundant than PP-1 in the mouse eye and appear to be highly regulated by various regulatory subunits; the genes encoding PP-1alpha/beta, PP-2Aalpha/beta, PP-2A-Aalpha/beta, and PP-2A-B alpha/beta/gamma are all differentially expressed.
    Title: Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC113781

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial fission ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial fragmentation involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
NP_001390894.1
NP_081807.1
NP_082668.1
XP_036017185.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403965.1 → NP_001390894.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC101740, AC140245

  2. NM_027531.2 → NP_081807.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC101740, AC140245, BC088979
    UniProtKB/Swiss-Prot
    Q3UF60, Q6ZWR4, Q8K413, Q9D3B7, Q9D6I1
    UniProtKB/TrEMBL
    A0A668KLA9
    Related
    ENSMUSP00000113731.2, ENSMUST00000117687.8
    Conserved Domains (2) summary
    COG5170
    Location:22 → 438
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:27 → 75
    7WD40; WD40 repeat [structural motif]

  3. NM_028392.4 → NP_082668.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform 2

    See identical proteins and their annotated locations for NP_082668.1

    Status: VALIDATED

    Source sequence(s)
    AC099605, AC140245
    Consensus CDS
    CCDS29216.1
    UniProtKB/TrEMBL
    A0A668KLA9
    Related
    ENSMUSP00000025377.7, ENSMUST00000025377.14
    Conserved Domains (2) summary
    COG5170
    Location:25 → 441
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:30 → 78
    7WD40; WD40 repeat [structural motif]

RNA

  1. NR_175792.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC099605, AC101740, AC140245

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    42777811..43192827 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161292.1 → XP_036017185.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X2

    UniProtKB/TrEMBL
    A0A668KLA9
    Conserved Domains (2) summary
    COG5170
    Location:6 → 420
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:9 → 57
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZWR4.1 GenPept UniProtKB/Swiss-Prot:Q6ZWR4

Gene LinkOut

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