Bclaf1 BCL2-associated transcription factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bclaf1provided by MGI
Official Full Name: BCL2-associated transcription factor 1provided by MGI
Primary source: MGI:MGI:1917580
See related: Ensembl:ENSMUSG00000037608 AllianceGenome:MGI:1917580
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Btf; mKIAA0164; 2610102K23Rik; 2700025J07Rik; 2810454G14Rik; 5730534O06Rik
Summary: Predicted to enable DNA binding activity and transcription coregulator activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in nuclear speck. Predicted to be part of mediator complex. Is expressed in central nervous system; genitourinary system; retina; submandibular gland; and trachea. Orthologous to human BCLAF1 (BCL2 associated transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 24.7), CNS E14 (RPKM 17.4) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A3; 10 9.75 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (20187897..20218390)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (20310512..20342644)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Plaque Evaluation by Ultrasound and Transcriptomics Reveals BCLAF1 as a Regulator of Smooth Muscle Cell Lipid Transdifferentiation in Atherosclerosis.
Title: Plaque Evaluation by Ultrasound and Transcriptomics Reveals BCLAF1 as a Regulator of Smooth Muscle Cell Lipid Transdifferentiation in Atherosclerosis.
Bclaf1 regulates c-FLIP expression and protects cells from TNF-induced apoptosis and tissue injury.
Title: Bclaf1 regulates c-FLIP expression and protects cells from TNF-induced apoptosis and tissue injury.
The long noncoding RNA lncCIRBIL disrupts the nuclear translocation of Bclaf1 alleviating cardiac ischemia-reperfusion injury.
Title: The long noncoding RNA lncCIRBIL disrupts the nuclear translocation of Bclaf1 alleviating cardiac ischemia-reperfusion injury.
RAG-Mediated DNA Breaks Attenuate PU.1 Activity in Early B Cells through Activation of a SPIC-BCLAF1 Complex.
Title: RAG-Mediated DNA Breaks Attenuate PU.1 Activity in Early B Cells through Activation of a SPIC-BCLAF1 Complex.
myogenic differentiation is achieved through the specific interaction between Cry2 and Bclaf1, which stabilizes mRNAs encoding cyclin D1, a G1/S phase transition regulator, and Tmem176b, a transmembrane regulator for myogenic cell fusion.
Title: Cry2 Is Critical for Circadian Regulation of Myogenic Differentiation by Bclaf1-Mediated mRNA Stabilization of Cyclin D1 and Tmem176b.
Constitutive expression of the anti-apoptotic molecule Bfl1 (A1) in murine vascular Endothelial Cells leads to prolonged allograft survival due to modifying inflammation.
Title: Constitutive expression of the anti-apoptotic Bcl-2 family member A1 in murine endothelial cells leads to transplant tolerance.
Bclaf1 facilitates the differentiation of early retinal precursors into retinal ganglion cells, amacrine cells, and horizontal cells rather than into cone photoreceptors.
Title: Involvement of Bcl-2-associated transcription factor 1 in the differentiation of early-born retinal cells.
Sirt1 negatively regulates T cell activation via H3K56 deacetylation at the promoter region to inhibit transcription of Bclaf1
Title: The type III histone deacetylase Sirt1 protein suppresses p300-mediated histone H3 lysine 56 acetylation at Bclaf1 promoter to inhibit T cell activation.
Bclaf1 expression was found to be strongly upregulated during the saccular stage of murine embryonic lung development and was dispensable for thymocyte development.
Title: Essential role for Bclaf1 in lung development and immune system function.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (4) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236316

UniSTS:236317 (e-PCR)
- UniSTS:236317

AW556225 (e-PCR)
- UniSTS:180013

D11Bhm20 (e-PCR), detects polymorphism
- UniSTS:141619

D10Csu2 (e-PCR), detects polymorphism
- UniSTS:526005

D10Csu3 (e-PCR), detects polymorphism
- UniSTS:526006

AI450190 (e-PCR)
- UniSTS:159958

STS-AA037848 (e-PCR)
- UniSTS:28133

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription initiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of mediator complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bcl-2-associated transcription factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025392.1 → NP_001020563.1 bcl-2-associated transcription factor 1 isoform 1

See identical proteins and their annotated locations for NP_001020563.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

BC029682, BC034300, BY071148, CAAA01031508

Consensus CDS

CCDS35858.1

UniProtKB/Swiss-Prot

Q8BNZ0, Q8C2E9, Q8K019, Q9CSW5

UniProtKB/TrEMBL

Q3UDL9

Related

ENSMUSP00000043583.6, ENSMUST00000043881.12

Conserved Domains (2) summary

pfam15440
Location:157 → 744

THRAP3_BCLAF1; THRAP3/BCLAF1 family

cl09653
Location:826 → 891

Btz; CASC3/Barentsz eIF4AIII binding
NM_001025393.1 → NP_001020564.1 bcl-2-associated transcription factor 1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an in-frame exon in the 3' coding region, as compared to variant 1. The encoded isoform 3 lacks an internal segment, as compared to isoform 1.

Source sequence(s)

BC086624, BY071148, CAAA01031508, CK637794, CN530237

Consensus CDS

CCDS23721.1

UniProtKB/TrEMBL

F8WI22, Q3UDL9

Related

ENSMUSP00000090349.4, ENSMUST00000092678.10

Conserved Domains (1) summary

pfam15440
Location:157 → 744

THRAP3_BCLAF1; THRAP3/BCLAF1 family
NM_153787.2 → NP_722482.1 bcl-2-associated transcription factor 1 isoform 2

See identical proteins and their annotated locations for NP_722482.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks a 6-nt segment in the CDS, as compared to variant 1. The encoded isoform 2 lacks 2 internal aa, as compared to isoform 1.

Source sequence(s)

BC034300, BY071148, CAAA01031508

Consensus CDS

CCDS78798.1

UniProtKB/TrEMBL

Q3UDL9

Related

ENSMUSP00000140623.2, ENSMUST00000185800.7

Conserved Domains (2) summary

pfam15440
Location:155 → 742

THRAP3_BCLAF1; THRAP3/BCLAF1 family

cl09653
Location:824 → 889

Btz; CASC3/Barentsz eIF4AIII binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

20187897..20218390

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006512865.5 → XP_006512928.1 bcl-2-associated transcription factor 1 isoform X1

UniProtKB/TrEMBL

Q3UDL9

Conserved Domains (1) summary

pfam15440
Location:155 → 744

THRAP3_BCLAF1; THRAP3/BCLAF1 family
XM_011243207.4 → XP_011241509.1 bcl-2-associated transcription factor 1 isoform X2

UniProtKB/TrEMBL

A0A087WQA0, Q3TSZ0

Related

ENSMUSP00000140101.2, ENSMUST00000186100.7

Conserved Domains (1) summary

pfam15440
Location:157 → 739

THRAP3_BCLAF1; THRAP3/BCLAF1 family

RNA

XR_004936284.1 RNA Sequence
XR_004936287.1 RNA Sequence
XR_004936289.1 RNA Sequence
XR_004936286.1 RNA Sequence
XR_004936288.1 RNA Sequence
XR_004936285.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001025394.1: Suppressed sequence

Description

NM_001025394.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.