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Rbm12b1 RNA binding motif protein 12 B1 [ Mus musculus (house mouse) ]

Gene ID: 72397, updated on 11-Apr-2024

Summary

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Official Symbol
Rbm12b1provided by MGI
Official Full Name
RNA binding motif protein 12 B1provided by MGI
Primary source
MGI:MGI:1919647
See related
Ensembl:ENSMUSG00000046667 AllianceGenome:MGI:1919647
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rbm12b; Rbm12ba; 3000004N20Rik
Summary
Predicted to enable RNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Is expressed in central nervous system and olfactory epithelium. Orthologous to human RBM12B (RNA binding motif protein 12B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E14 (RPKM 5.4), CNS E18 (RPKM 5.1) and 25 other tissues See more
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Genomic context

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See Rbm12b1 in Genome Data Viewer
Location:
4 A1; 4 5.58 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (12138957..12148922)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (12138957..12148922)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene poly A binding protein, cytoplasmic 4 pseudogene Neighboring gene poly A binding protein, cytoplasmic 4 pseudogene Neighboring gene ubiquitin-conjugating enzyme E2 variant 2 pseudogene Neighboring gene CBY1 interacting BAR domain containing 1 Neighboring gene predicted gene, 46845 Neighboring gene predicted gene, 46846

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
  2. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA-binding protein 12B-A
Names
RNA binding motif protein 12B
RNA-binding motif protein 12B-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028226.2 → NP_082502.2  RNA-binding protein 12B-A

    See identical proteins and their annotated locations for NP_082502.2

    Status: VALIDATED

    Source sequence(s)
    AK013872, AL929413, BC050844, BP767112
    Consensus CDS
    CCDS17976.1
    UniProtKB/Swiss-Prot
    B1AZ74, Q7TQK7, Q80YR9, Q8CD70, Q9CRY6
    UniProtKB/TrEMBL
    B2RPV4
    Related
    ENSMUSP00000064195.8, ENSMUST00000069128.8
    Conserved Domains (5) summary
    PTZ00465
    Location:601 → 708
    PTZ00465; rhoptry-associated protein 1 (RAP-1); Provisional
    COG0724
    Location:367 → 559
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12746
    Location:152 → 237
    RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12748
    Location:401 → 476
    RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cl17169
    Location:2 → 80
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    12138957..12148922
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538274.2 → XP_006538337.1  RNA-binding protein 12B-A isoform X1

    See identical proteins and their annotated locations for XP_006538337.1

    UniProtKB/Swiss-Prot
    B1AZ74, Q7TQK7, Q80YR9, Q8CD70, Q9CRY6
    UniProtKB/TrEMBL
    B2RPV4
    Conserved Domains (5) summary
    PTZ00465
    Location:601 → 708
    PTZ00465; rhoptry-associated protein 1 (RAP-1); Provisional
    COG0724
    Location:367 → 559
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12746
    Location:152 → 237
    RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12748
    Location:401 → 476
    RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cl17169
    Location:2 → 80
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. XM_036164456.1 → XP_036020349.1  RNA-binding protein 12B-A isoform X1

    UniProtKB/Swiss-Prot
    B1AZ74, Q7TQK7, Q80YR9, Q8CD70, Q9CRY6
    UniProtKB/TrEMBL
    B2RPV4
    Conserved Domains (5) summary
    PTZ00465
    Location:601 → 708
    PTZ00465; rhoptry-associated protein 1 (RAP-1); Provisional
    COG0724
    Location:367 → 559
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12746
    Location:152 → 237
    RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12748
    Location:401 → 476
    RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cl17169
    Location:2 → 80
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. XM_006538271.4 → XP_006538334.1  RNA-binding protein 12B-A isoform X1

    See identical proteins and their annotated locations for XP_006538334.1

    UniProtKB/Swiss-Prot
    B1AZ74, Q7TQK7, Q80YR9, Q8CD70, Q9CRY6
    UniProtKB/TrEMBL
    B2RPV4
    Conserved Domains (5) summary
    PTZ00465
    Location:601 → 708
    PTZ00465; rhoptry-associated protein 1 (RAP-1); Provisional
    COG0724
    Location:367 → 559
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12746
    Location:152 → 237
    RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12748
    Location:401 → 476
    RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cl17169
    Location:2 → 80
    RRM_SF; RNA recognition motif (RRM) superfamily

  4. XM_006538272.4 → XP_006538335.1  RNA-binding protein 12B-A isoform X1

    See identical proteins and their annotated locations for XP_006538335.1

    UniProtKB/Swiss-Prot
    B1AZ74, Q7TQK7, Q80YR9, Q8CD70, Q9CRY6
    UniProtKB/TrEMBL
    B2RPV4
    Related
    ENSMUSP00000053555.3, ENSMUST00000050069.9
    Conserved Domains (5) summary
    PTZ00465
    Location:601 → 708
    PTZ00465; rhoptry-associated protein 1 (RAP-1); Provisional
    COG0724
    Location:367 → 559
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12746
    Location:152 → 237
    RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12748
    Location:401 → 476
    RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cl17169
    Location:2 → 80
    RRM_SF; RNA recognition motif (RRM) superfamily

  5. XM_030253810.1 → XP_030109670.1  RNA-binding protein 12B-A isoform X1

    UniProtKB/Swiss-Prot
    B1AZ74, Q7TQK7, Q80YR9, Q8CD70, Q9CRY6
    UniProtKB/TrEMBL
    B2RPV4
    Conserved Domains (5) summary
    PTZ00465
    Location:601 → 708
    PTZ00465; rhoptry-associated protein 1 (RAP-1); Provisional
    COG0724
    Location:367 → 559
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12746
    Location:152 → 237
    RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12748
    Location:401 → 476
    RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cl17169
    Location:2 → 80
    RRM_SF; RNA recognition motif (RRM) superfamily

  6. XM_006538273.4 → XP_006538336.1  RNA-binding protein 12B-A isoform X1

    See identical proteins and their annotated locations for XP_006538336.1

    UniProtKB/Swiss-Prot
    B1AZ74, Q7TQK7, Q80YR9, Q8CD70, Q9CRY6
    UniProtKB/TrEMBL
    B2RPV4
    Conserved Domains (5) summary
    PTZ00465
    Location:601 → 708
    PTZ00465; rhoptry-associated protein 1 (RAP-1); Provisional
    COG0724
    Location:367 → 559
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12746
    Location:152 → 237
    RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12748
    Location:401 → 476
    RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cl17169
    Location:2 → 80
    RRM_SF; RNA recognition motif (RRM) superfamily

  7. XM_036164457.1 → XP_036020350.1  RNA-binding protein 12B-A isoform X1

    UniProtKB/Swiss-Prot
    B1AZ74, Q7TQK7, Q80YR9, Q8CD70, Q9CRY6
    UniProtKB/TrEMBL
    B2RPV4
    Conserved Domains (5) summary
    PTZ00465
    Location:601 → 708
    PTZ00465; rhoptry-associated protein 1 (RAP-1); Provisional
    COG0724
    Location:367 → 559
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12746
    Location:152 → 237
    RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12748
    Location:401 → 476
    RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cl17169
    Location:2 → 80
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80YR9.2 GenPept UniProtKB/Swiss-Prot:Q80YR9

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