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Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 [ Mus musculus (house mouse) ]

Gene ID: 72054, updated on 8-Feb-2024

Summary

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Official Symbol
Cyp4f18provided by MGI
Official Full Name
cytochrome P450, family 4, subfamily f, polypeptide 18provided by MGI
Primary source
MGI:MGI:1919304
See related
Ensembl:ENSMUSG00000003484 AllianceGenome:MGI:1919304
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cyp4f3; Cypf18; CYPIVF3; 1810054N16Rik
Summary
Predicted to enable monooxygenase activity. Predicted to be involved in monocarboxylic acid metabolic process and quinone catabolic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human CYP4F3 (cytochrome P450 family 4 subfamily F member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 31.6), mammary gland adult (RPKM 9.0) and 13 other tissues See more
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Genomic context

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Location:
8 B3.3; 8 34.67 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (72742326..72763512, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71988482..72009668, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10511 Neighboring gene zinc finger protein 617 Neighboring gene STARR-positive B cell enhancer ABC_E3784 Neighboring gene STARR-seq mESC enhancer starr_21836 Neighboring gene zinc finger protein 961 Neighboring gene STARR-seq mESC enhancer starr_21837 Neighboring gene STARR-seq mESC enhancer starr_21838 Neighboring gene predicted gene, 51535 Neighboring gene predicted gene 45734 Neighboring gene gem (nuclear organelle) associated protein 8 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic deletion of Cyp4f18 disrupts the omega-3 epoxidation pathway and results in psoriasis-like dermatitis. Yoshida M, et al. FASEB J, 2022 Dec. PMID 36374250
  2. Renal NKCC2 Is Dual Regulated by the Synergy of 20-HETE and High-Fat Diet in CYP4F2 Transgenic Mice. Wu J, et al. Kidney Blood Press Res, 2021. PMID 34320496
  3. CYP4F18-Deficient Neutrophils Exhibit Increased Chemotaxis to Complement Component C5a. Vaivoda R, et al. J Immunol Res, 2015. PMID 26613087, Free PMC Article
  4. Altered leukotriene B4 metabolism in CYP4F18-deficient mice does not impact inflammation following renal ischemia. Winslow V, et al. Biochim Biophys Acta, 2014 Jun. PMID 24632148, Free PMC Article
  5. The cytochromes P450 (CYP) response to allergic inflammation of the lung. Stoilov I, et al. Arch Biochem Biophys, 2006 Dec 1. PMID 17081494

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic deletion of Cyp4f18 disrupts the omega-3 epoxidation pathway and results in psoriasis-like dermatitis.
    Title: Genetic deletion of Cyp4f18 disrupts the omega-3 epoxidation pathway and results in psoriasis-like dermatitis.
  2. Renal NKCC2 Is Dual Regulated by the Synergy of 20-HETE and High-Fat Diet in CYP4F2 Transgenic Mice.
    Title: Renal NKCC2 Is Dual Regulated by the Synergy of 20-HETE and High-Fat Diet in CYP4F2 Transgenic Mice.
  3. CYP4F18-deficient neutrophils exhibit increased chemotaxis to complement component C5a.
    Title: CYP4F18-Deficient Neutrophils Exhibit Increased Chemotaxis to Complement Component C5a.
  4. It is concluded that CYP4F18 is necessary for omega oxidation of leukotriene B4 in neutrophils, and is not compensated by other CYP enzymes
    Title: Altered leukotriene B4 metabolism in CYP4F18-deficient mice does not impact inflammation following renal ischemia.
  5. The mRNA levels of Cyp4f18 increase with the development of allergic inflammation in the lung.
    Title: The cytochromes P450 (CYP) response to allergic inflammation of the lung.
  6. CYP4F18 is a critical protein in the regulation of LTB(4) metabolism
    Title: Cytochrome P-450 4F18 is the leukotriene B4 omega-1/omega-2 hydroxylase in mouse polymorphonuclear leukocytes: identification as the functional orthologue of human polymorphonuclear leukocyte CYP4F3A in the down-regulation of responses to LTB4.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 20-aldehyde-leukotriene B4 20-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables 20-hydroxy-leukotriene B4 omega oxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables alkane 1-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables alpha-tocopherol omega-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables arachidonic acid epoxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables arachidonic acid omega-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables leukotriene-B4 20-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables long-chain fatty acid omega-1 hydroxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables long-chain fatty acid omega-1 hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables long-chain fatty acid omega-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen ISO
Inferred from Sequence Orthology
more info
  
enables tocotrienol omega-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables very long-chain fatty acid omega-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in leukotriene B4 metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome P450 4F3
Names
cytochrome P450 CYP4F18
cytochrome P450, 4f18
cytochrome P450-LTB-omega
leukotriene-B(4) 20-monooxygenase 2
leukotriene-B(4) omega-1/omega-2 hydroxylase
leukotriene-B(4) omega-hydroxylase 2
NP_077764.2
XP_006509811.1
XP_006509812.1
XP_011240629.1
XP_030099642.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024444.2 → NP_077764.2  cytochrome P450 4F3

    See identical proteins and their annotated locations for NP_077764.2

    Status: VALIDATED

    Source sequence(s)
    AC162522, AK007863, BB804325
    Consensus CDS
    CCDS22406.1
    UniProtKB/Swiss-Prot
    E9QLZ3, Q99N16, Q9D8N4
    Related
    ENSMUSP00000003574.5, ENSMUST00000003574.5
    Conserved Domains (1) summary
    pfam00067
    Location:52 → 516
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    72742326..72763512 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242327.3 → XP_011240629.1  cytochrome P450 4F3 isoform X2

    Conserved Domains (1) summary
    pfam00067
    Location:52 → 381
    p450; Cytochrome P450

  2. XM_006509748.3 → XP_006509811.1  cytochrome P450 4F3 isoform X1

    See identical proteins and their annotated locations for XP_006509811.1

    UniProtKB/Swiss-Prot
    E9QLZ3, Q99N16, Q9D8N4
    Conserved Domains (1) summary
    pfam00067
    Location:52 → 516
    p450; Cytochrome P450

  3. XM_006509749.5 → XP_006509812.1  cytochrome P450 4F3 isoform X3

    Conserved Domains (1) summary
    pfam00067
    Location:1 → 379
    p450; Cytochrome P450

  4. XM_030243782.1 → XP_030099642.1  cytochrome P450 4F3 isoform X3

    Conserved Domains (1) summary
    pfam00067
    Location:1 → 379
    p450; Cytochrome P450
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99N16.2 GenPept UniProtKB/Swiss-Prot:Q99N16

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