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Ppm1j protein phosphatase 1J [ Mus musculus (house mouse) ]

Gene ID: 71887, updated on 5-Mar-2024

Summary

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Official Symbol
Ppm1jprovided by MGI
Official Full Name
protein phosphatase 1Jprovided by MGI
Primary source
MGI:MGI:1919137
See related
Ensembl:ENSMUSG00000002228 AllianceGenome:MGI:1919137
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ppp2cz; PP2Czeta; 2310008J22Rik
Summary
Enables protein serine/threonine phosphatase activity. Acts upstream of or within protein dephosphorylation. Is expressed in dorsal root ganglion; lower jaw molar; telencephalon mantle layer; trigeminal ganglion; and upper jaw molar. Orthologous to human PPM1J (protein phosphatase, Mg2+/Mn2+ dependent 1J). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 43.9), duodenum adult (RPKM 15.0) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Ppm1j in Genome Data Viewer
Location:
3 F2.2; 3 45.85 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (104688322..104693334)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (104780952..104786023)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 6485 Neighboring gene TAFA chemokine like family member 3 Neighboring gene STARR-seq mESC enhancer starr_08620 Neighboring gene ras homolog family member C Neighboring gene Mov10 RISC complex RNA helicase Neighboring gene STARR-seq mESC enhancer starr_08622

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phosphorylation of protein phosphatase 2Czeta by c-Jun NH2-terminal kinase at Ser92 attenuates its phosphatase activity. Awano K, et al. Biochemistry, 2008 Jul 8. PMID 18553930
  2. A novel protein phosphatase 2C family member (PP2Czeta) is able to associate with ubiquitin conjugating enzyme 9. Kashiwaba M, et al. FEBS Lett, 2003 Mar 13. PMID 12633878
  3. Molecular cloning of PP2Ceta, a novel member of the protein phosphatase 2C family. Komaki K, et al. Biochim Biophys Acta, 2003 Nov 30. PMID 14654243
  4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that specific phosphorylation of PP2Czeta at Ser (92) by stress-activated JNK attenuates its phosphatase activity in cells.
    Title: Phosphorylation of protein phosphatase 2Czeta by c-Jun NH2-terminal kinase at Ser92 attenuates its phosphatase activity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC144853

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein phosphatase 1J
Names
PP2C-zeta
protein phosphatase 2C zeta
NP_082258.2
XP_006502185.1
XP_006502186.1
XP_036019233.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027982.2 → NP_082258.2  protein phosphatase 1J

    See identical proteins and their annotated locations for NP_082258.2

    Status: VALIDATED

    Source sequence(s)
    AC122831, BC117498, BX518856
    Consensus CDS
    CCDS17703.1
    UniProtKB/Swiss-Prot
    Q149T7, Q810X6, Q9D7H6
    Related
    ENSMUSP00000002298.7, ENSMUST00000002298.7
    Conserved Domains (1) summary
    cd00143
    Location:105 → 499
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    104688322..104693334
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163340.1 → XP_036019233.1  protein phosphatase 1J isoform X2

    Conserved Domains (1) summary
    cd00143
    Location:105 → 440
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

  2. XM_006502122.5 → XP_006502185.1  protein phosphatase 1J isoform X1

    Conserved Domains (1) summary
    cd00143
    Location:105 → 482
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

  3. XM_006502123.5 → XP_006502186.1  protein phosphatase 1J isoform X3

    Conserved Domains (1) summary
    cd00143
    Location:56 → 449
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q149T7.1 GenPept UniProtKB/Swiss-Prot:Q149T7

Gene LinkOut

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