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Trnau1ap tRNA selenocysteine 1 associated protein 1 [ Mus musculus (house mouse) ]

Gene ID: 71787, updated on 5-Mar-2024

Summary

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Official Symbol
Trnau1approvided by MGI
Official Full Name
tRNA selenocysteine 1 associated protein 1provided by MGI
Primary source
MGI:MGI:1919037
See related
Ensembl:ENSMUSG00000028898 AllianceGenome:MGI:1919037
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Secp43; Trspap1; 1110007F05Rik; WI1-2643G14.2
Summary
Predicted to enable tRNA binding activity. Involved in selenocysteine incorporation. Located in nucleus. Is expressed in brain; olfactory epithelium; and spinal cord. Orthologous to human TRNAU1AP (tRNA selenocysteine 1 associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 7.1), CNS E11.5 (RPKM 6.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.3; 4 65.16 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132039074..132058007, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132311763..132330696, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7994 Neighboring gene small nucleolar RNA host gene 12 Neighboring gene small nucleolar RNA, H/ACA box 61 Neighboring gene small nucleolar RNA, C/D box 99 Neighboring gene regulator of chromosome condensation 1 Neighboring gene CRISPRi-validated cis-regulatory element for Rcc1 and Trnau1ap Neighboring gene small nucleolar RNA, H/ACA box 73b Neighboring gene small nucleolar RNA host gene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Knockdown of Trnau1ap inhibits the proliferation and migration of NIH3T3, JEG-3 and Bewo cells via the PI3K/Akt signaling pathway. Hu X, et al. Biochem Biophys Res Commun, 2018 Sep 5. PMID 29758194
  2. Expression of Selenoproteins Is Maintained in Mice Carrying Mutations in SECp43, the tRNA Selenocysteine 1 Associated Protein (Trnau1ap). Mahdi Y, et al. PLoS One, 2015. PMID 26043259, Free PMC Article
  3. Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery. Xu XM, et al. J Biol Chem, 2005 Dec 16. PMID 16230358
  4. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown of Trnau1ap reduced cell migration and proliferation. Knockdown of Trnau1ap blocked the PI3K/Akt signaling pathway.
    Title: Knockdown of Trnau1ap inhibits the proliferation and migration of NIH3T3, JEG-3 and Bewo cells via the PI3K/Akt signaling pathway.
  2. These findings suggest that the targeted domains in the SECp43 protein are not essential for selenoprotein biosynthesis in hepatocytes and neurons.
    Title: Expression of Selenoproteins Is Maintained in Mice Carrying Mutations in SECp43, the tRNA Selenocysteine 1 Associated Protein (Trnau1ap).
  3. SECp43 and SLA have roles in selenoprotein synthesis
    Title: Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in selenocysteine incorporation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in selenocysteine incorporation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tRNA selenocysteine 1-associated protein 1
Names
tRNA selenocysteine-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027925.3 → NP_082201.2  tRNA selenocysteine 1-associated protein 1

    See identical proteins and their annotated locations for NP_082201.2

    Status: VALIDATED

    Source sequence(s)
    AK152986, BC099594, BY283216, CJ166630
    Consensus CDS
    CCDS18722.1
    UniProtKB/Swiss-Prot
    Q05DN9, Q4FZE9, Q7TMM7, Q80VC6
    Related
    ENSMUSP00000030730.8, ENSMUST00000030730.14
    Conserved Domains (2) summary
    cd12610
    Location:4 → 87
    RRM1_SECp43; RNA recognition motif 1 in tRNA selenocysteine-associated protein 1 (SECp43)
    cd12612
    Location:95 → 176
    RRM2_SECp43; RNA recognition motif 2 in tRNA selenocysteine-associated protein 1 (SECp43)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    132039074..132058007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539180.4 → XP_006539243.1  tRNA selenocysteine 1-associated protein 1 isoform X1

    Conserved Domains (2) summary
    cd12612
    Location:29 → 110
    RRM2_SECp43; RNA recognition motif 2 in tRNA selenocysteine-associated protein 1 (SECp43)
    pfam17654
    Location:139 → 218
    Trnau1ap; Selenocysteine tRNA 1 associated proteins

  2. XM_011250332.3 → XP_011248634.1  tRNA selenocysteine 1-associated protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011248634.1

    Related
    ENSMUST00000146166.8
    Conserved Domains (2) summary
    pfam17654
    Location:95 → 174
    Trnau1ap; Selenocysteine tRNA 1 associated proteins
    cl17169
    Location:1 → 66
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. XM_011250334.3 → XP_011248636.1  tRNA selenocysteine 1-associated protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011248636.1

    Conserved Domains (2) summary
    pfam17654
    Location:95 → 174
    Trnau1ap; Selenocysteine tRNA 1 associated proteins
    cl17169
    Location:1 → 66
    RRM_SF; RNA recognition motif (RRM) superfamily

  4. XM_030253783.2 → XP_030109643.1  tRNA selenocysteine 1-associated protein 1 isoform X2

    Conserved Domains (2) summary
    pfam17654
    Location:95 → 174
    Trnau1ap; Selenocysteine tRNA 1 associated proteins
    cl17169
    Location:1 → 66
    RRM_SF; RNA recognition motif (RRM) superfamily

  5. XM_017320388.3 → XP_017175877.1  tRNA selenocysteine 1-associated protein 1 isoform X2

    Conserved Domains (2) summary
    pfam17654
    Location:95 → 174
    Trnau1ap; Selenocysteine tRNA 1 associated proteins
    cl17169
    Location:1 → 66
    RRM_SF; RNA recognition motif (RRM) superfamily

  6. XM_030253782.2 → XP_030109642.1  tRNA selenocysteine 1-associated protein 1 isoform X2

    Conserved Domains (2) summary
    pfam17654
    Location:95 → 174
    Trnau1ap; Selenocysteine tRNA 1 associated proteins
    cl17169
    Location:1 → 66
    RRM_SF; RNA recognition motif (RRM) superfamily

  7. XM_030253784.1 → XP_030109644.1  tRNA selenocysteine 1-associated protein 1 isoform X2

    Conserved Domains (2) summary
    pfam17654
    Location:95 → 174
    Trnau1ap; Selenocysteine tRNA 1 associated proteins
    cl17169
    Location:1 → 66
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80VC6.2 GenPept UniProtKB/Swiss-Prot:Q80VC6

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