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Map3k13 mitogen-activated protein kinase kinase kinase 13 [ Mus musculus (house mouse) ]

Gene ID: 71751, updated on 5-Mar-2024

Summary

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Official Symbol
Map3k13provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase 13provided by MGI
Primary source
MGI:MGI:2444243
See related
Ensembl:ENSMUSG00000033618 AllianceGenome:MGI:2444243
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LZK; C130026N12Rik
Summary
Predicted to enable several functions, including IkappaB kinase complex binding activity; JUN kinase kinase kinase activity; and protein homodimerization activity. Involved in several processes, including positive regulation of JUN kinase activity; positive regulation of branching morphogenesis of a nerve; and positive regulation of cell projection organization. Predicted to be located in membrane. Is expressed in diencephalon lateral wall mantle layer; dorsal grey horn; late tubule; midbrain mantle layer; and ureter. Orthologous to human MAP3K13 (mitogen-activated protein kinase kinase kinase 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 1.4), small intestine adult (RPKM 1.3) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B1; 16 12.92 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (21643923..21752189)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (21824056..21933439)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase Neighboring gene RIKEN cDNA 1300002E11 gene Neighboring gene STARR-positive B cell enhancer ABC_E8908 Neighboring gene STARR-seq mESC enhancer starr_40372 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:21835806-21835989 Neighboring gene predicted gene, 49607 Neighboring gene predicted gene, 26744 Neighboring gene 60S ribosomal protein L12 pseudogene Neighboring gene proteasome (prosome, macropain) subunit, beta type 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40374 Neighboring gene transmembrane protein 41a Neighboring gene lipase, member H Neighboring gene STARR-seq mESC enhancer starr_40375 Neighboring gene STARR-seq mESC enhancer starr_40377 Neighboring gene STARR-seq mESC enhancer starr_40378

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A Critical Role for DLK and LZK in Axonal Repair in the Mammalian Spinal Cord. Saikia JM, et al. J Neurosci, 2022 May 4. PMID 35361703, Free PMC Article
  2. Leucine Zipper-Bearing Kinase Is a Critical Regulator of Astrocyte Reactivity in the Adult Mammalian CNS. Chen M, et al. Cell Rep, 2018 Mar 27. PMID 29590625, Free PMC Article
  3. Impaired regenerative response of primary sensory neurons in ZPK/DLK gene-trap mice. Itoh A, et al. Biochem Biophys Res Commun, 2009 May 29. PMID 19358824
  4. POSH is an intracellular signal transducer for the axon outgrowth inhibitor Nogo66. Dickson HM, et al. J Neurosci, 2010 Oct 6. PMID 20926658, Free PMC Article
  5. Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength. Li Y, et al. Elife, 2021 Jan 21. PMID 33475086, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Critical Role for DLK and LZK in Axonal Repair in the Mammalian Spinal Cord.
    Title: A Critical Role for DLK and LZK in Axonal Repair in the Mammalian Spinal Cord.
  2. Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength.
    Title: Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength.
  3. LZK overexpression in astrocytes enhanced astrogliosis and reduced lesion size. Remarkably, in the absence of injury, LZK overexpression alone induced widespread astrogliosis in the CNS and upregulated astrogliosis activators pSTAT3 and SOX9.
    Title: Leucine Zipper-Bearing Kinase Is a Critical Regulator of Astrocyte Reactivity in the Adult Mammalian CNS.
  4. By gain- and loss-of-function analyses in neuronal cultures, the authors identify LZK as a novel positive regulator of axon growth.
    Title: Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons.
  5. LZK cooperates with DLK to promote retinal ganglion cell death in response to axon injury.
    Title: Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons.
  6. Scaffold protein POSH, in association with Shroom3 and mixed lineage kinase LZK, relays axon outgrowth inhibition downstream of NogoA and PirB proteins.
    Title: POSH is an intracellular signal transducer for the axon outgrowth inhibitor Nogo66.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables IkappaB kinase complex binding ISO
Inferred from Sequence Orthology
more info
  
enables JUN kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase kinase kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in JNK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of JUN kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of branching morphogenesis of a nerve IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron projection arborization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase 13
NP_766409.2
XP_006522645.1
XP_006522646.1
XP_006522647.1
XP_011244317.1
XP_011244318.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172821.3 → NP_766409.2  mitogen-activated protein kinase kinase kinase 13

    See identical proteins and their annotated locations for NP_766409.2

    Status: VALIDATED

    Source sequence(s)
    AK047986, AK054039, BB455895, BB549158, BP761466, CX240141, DQ480427
    Consensus CDS
    CCDS37294.1
    UniProtKB/Swiss-Prot
    Q1HKZ5, Q8BKN0
    Related
    ENSMUSP00000047388.7, ENSMUST00000042065.7
    Conserved Domains (1) summary
    cd14059
    Location:173 → 409
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    21643923..21752189
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522583.5 → XP_006522646.1  mitogen-activated protein kinase kinase kinase 13 isoform X1

    See identical proteins and their annotated locations for XP_006522646.1

    UniProtKB/Swiss-Prot
    Q1HKZ5, Q8BKN0
    Related
    ENSMUSP00000156202.2, ENSMUST00000232240.2
    Conserved Domains (1) summary
    cd14059
    Location:173 → 409
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

  2. XM_006522582.4 → XP_006522645.1  mitogen-activated protein kinase kinase kinase 13 isoform X1

    See identical proteins and their annotated locations for XP_006522645.1

    UniProtKB/Swiss-Prot
    Q1HKZ5, Q8BKN0
    Related
    ENSMUSP00000156075.2, ENSMUST00000231988.2
    Conserved Domains (1) summary
    cd14059
    Location:173 → 409
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

  3. XM_011246016.2 → XP_011244318.1  mitogen-activated protein kinase kinase kinase 13 isoform X1

    See identical proteins and their annotated locations for XP_011244318.1

    UniProtKB/Swiss-Prot
    Q1HKZ5, Q8BKN0
    Conserved Domains (1) summary
    cd14059
    Location:173 → 409
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

  4. XM_011246015.3 → XP_011244317.1  mitogen-activated protein kinase kinase kinase 13 isoform X1

    See identical proteins and their annotated locations for XP_011244317.1

    UniProtKB/Swiss-Prot
    Q1HKZ5, Q8BKN0
    Conserved Domains (1) summary
    cd14059
    Location:173 → 409
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

  5. XM_006522584.4 → XP_006522647.1  mitogen-activated protein kinase kinase kinase 13 isoform X1

    See identical proteins and their annotated locations for XP_006522647.1

    UniProtKB/Swiss-Prot
    Q1HKZ5, Q8BKN0
    Conserved Domains (1) summary
    cd14059
    Location:173 → 409
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1HKZ5.1 GenPept UniProtKB/Swiss-Prot:Q1HKZ5

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