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Tut1 terminal uridylyl transferase 1, U6 snRNA-specific [ Mus musculus (house mouse) ]

Gene ID: 70044, updated on 11-Apr-2024

Summary

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Official Symbol
Tut1provided by MGI
Official Full Name
terminal uridylyl transferase 1, U6 snRNA-specificprovided by MGI
Primary source
MGI:MGI:1917294
See related
Ensembl:ENSMUSG00000071645 AllianceGenome:MGI:1917294
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PAPD2; Rbm21; Tent1; TUTase6; star-PAP; U6-TUTase; 2700038E08Rik
Summary
Predicted to enable RNA binding activity; enzyme binding activity; and nucleotidyltransferase activity. Predicted to be involved in U6 snRNA 3'-end processing; mRNA polyadenylation; and pre-mRNA cleavage required for polyadenylation. Predicted to act upstream of or within mRNA processing. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Predicted to be active in nuclear speck. Is expressed in central nervous system; genitourinary system; and sensory organ. Orthologous to human TUT1 (terminal uridylyl transferase 1, U6 snRNA-specific). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 15.7), thymus adult (RPKM 11.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 6.04 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8931199..8943572)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8953832..8966210)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5684 Neighboring gene echinoderm microtubule associated protein like 3 Neighboring gene rod outer segment membrane protein 1 Neighboring gene predicted gene 10353 Neighboring gene STARR-positive B cell enhancer ABC_E11018 Neighboring gene metastasis-associated gene family, member 2 Neighboring gene STARR-positive B cell enhancer ABC_E3241 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:9041491-9041707 Neighboring gene eukaryotic translation elongation factor 1 gamma Neighboring gene STARR-positive B cell enhancer ABC_E3242 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:9072131-9072314 Neighboring gene AHNAK nucleoprotein Neighboring gene STARR-positive B cell enhancer ABC_E5685

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Primordial dwarfism gene maintains Lin28 expression to safeguard embryonic stem cells from premature differentiation. Dai Q, et al. Cell Rep, 2014 May 8. PMID 24768001
  2. LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice. Wang X, et al. Mol Cell, 2020 Mar 5. PMID 32017896
  3. USP15 Deubiquitinates TUT1 Associated with RNA Metabolism and Maintains Cerebellar Homeostasis. Kim J, et al. Mol Cell Biol, 2020 Oct 13. PMID 32839293, Free PMC Article
  4. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
  5. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. USP15 Deubiquitinates TUT1 Associated with RNA Metabolism and Maintains Cerebellar Homeostasis.
    Title: USP15 Deubiquitinates TUT1 Associated with RNA Metabolism and Maintains Cerebellar Homeostasis.
  2. TUT1 nucleotidyl transferase interacts with LARP7 protein to regulate Lin28 expression.
    Title: Primordial dwarfism gene maintains Lin28 expression to safeguard embryonic stem cells from premature differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA uridylyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables U6 snRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A) RNA polymerase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in U6 snRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
  
involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in snRNA processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of mRNA cleavage and polyadenylation specificity factor complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
speckle targeted PIP5K1A-regulated poly(A) polymerase
Names
RNA binding motif protein 21
NP_932110.1
XP_030106934.1
XP_036017576.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_197993.4 → NP_932110.1  speckle targeted PIP5K1A-regulated poly(A) polymerase

    See identical proteins and their annotated locations for NP_932110.1

    Status: VALIDATED

    Source sequence(s)
    AC130819
    Consensus CDS
    CCDS29562.1
    UniProtKB/Swiss-Prot
    Q3UUH3, Q8R3F9
    Related
    ENSMUSP00000093958.6, ENSMUST00000096239.7
    Conserved Domains (4) summary
    cd05402
    Location:179 → 403
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    smart00451
    Location:14 → 47
    ZnF_U1; U1-like zinc finger
    COG0724
    Location:56 → 140
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12279
    Location:54 → 127
    RRM_TUT1; RNA recognition motif in speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    8931199..8943572
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251074.2 → XP_030106934.1  speckle targeted PIP5K1A-regulated poly(A) polymerase isoform X1

    Conserved Domains (3) summary
    cd05402
    Location:81 → 305
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    COG5260
    Location:262 → 355
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
    cl17169
    Location:1 → 29
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. XM_036161683.1 → XP_036017576.1  speckle targeted PIP5K1A-regulated poly(A) polymerase isoform X2

    Conserved Domains (2) summary
    pfam03828
    Location:89 → 148
    PAP_assoc; Cid1 family poly A polymerase
    pfam19088
    Location:4 → 50
    TUTase; TUTase nucleotidyltransferase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R3F9.1 GenPept UniProtKB/Swiss-Prot:Q8R3F9

Gene LinkOut

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