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Ndufa11 NADH:ubiquinone oxidoreductase subunit A11 [ Mus musculus (house mouse) ]

Gene ID: 69875, updated on 5-Mar-2024

Summary

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Official Symbol
Ndufa11provided by MGI
Official Full Name
NADH:ubiquinone oxidoreductase subunit A11provided by MGI
Primary source
MGI:MGI:1917125
See related
Ensembl:ENSMUSG00000002379 AllianceGenome:MGI:1917125
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B14.7; 2010012C24Rik
Summary
Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Is expressed in genitourinary system. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 14. Orthologous to human NDUFA11 (NADH:ubiquinone oxidoreductase subunit A11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 87.4), duodenum adult (RPKM 80.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 29.47 cM; 17 D
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (57024762..57031248)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56717762..56724248)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RAN binding protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E962 Neighboring gene calcyphosine, pseudogene Neighboring gene vimentin-type intermediate filament associated coiled-coil protein Neighboring gene fucosyltransferase 4, pseudogene 1 Neighboring gene neurturin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes. Signes A, et al. Essays Biochem, 2018 Jul 20. PMID 30030361, Free PMC Article
  2. Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome. Grose JH, et al. PLoS One, 2015. PMID 26465331, Free PMC Article
  3. Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions. McFarland MA, et al. Mol Cell Proteomics, 2008 Nov. PMID 18614564, Free PMC Article
  4. Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Combes AN, et al. Dev Dyn, 2009 May. PMID 19334288, Free PMC Article
  5. Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub. Forrest MP, et al. Nat Commun, 2023 Feb 17. PMID 36808153, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in aerobic respiration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in proton motive force-driven mitochondrial ATP synthesis NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in respirasome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11
Names
CI-B14.7
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 11
NADH-ubiquinone oxidoreductase subunit B14.7
complex I-B14.7
NP_081520.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027244.1 → NP_081520.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11

    See identical proteins and their annotated locations for NP_081520.1

    Status: VALIDATED

    Source sequence(s)
    CT010491
    Consensus CDS
    CCDS50155.1
    UniProtKB/Swiss-Prot
    Q9D8B4
    UniProtKB/TrEMBL
    G5E814
    Related
    ENSMUSP00000002452.7, ENSMUST00000002452.8
    Conserved Domains (1) summary
    pfam02466
    Location:20 → 124
    Tim17; Tim17/Tim22/Tim23/Pmp24 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    57024762..57031248
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D8B4.2 GenPept UniProtKB/Swiss-Prot:Q9D8B4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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