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Mtfmt mitochondrial methionyl-tRNA formyltransferase [ Mus musculus (house mouse) ]

Gene ID: 69606, updated on 28-Apr-2024

Summary

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Official Symbol
Mtfmtprovided by MGI
Official Full Name
mitochondrial methionyl-tRNA formyltransferaseprovided by MGI
Primary source
MGI:MGI:1916856
See related
Ensembl:ENSMUSG00000059183 AllianceGenome:MGI:1916856
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310020P08Rik
Summary
Predicted to enable methionyl-tRNA formyltransferase activity. Predicted to be involved in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA. Predicted to act upstream of or within translation. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 15 and nuclear type mitochondrial complex I deficiency 27. Orthologous to human MTFMT (mitochondrial methionyl-tRNA formyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 5.3), CNS E14 (RPKM 5.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 C; 9 35.31 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (65343064..65360336)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (65435782..65453054)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene kelch repeat and BTB (POZ) domain containing 13 Neighboring gene RAS-like, family 12 Neighboring gene solute carrier family 51, beta subunit Neighboring gene STARR-positive B cell enhancer ABC_E6755 Neighboring gene STARR-positive B cell enhancer ABC_E2295 Neighboring gene STARR-positive B cell enhancer ABC_E2895 Neighboring gene SPG21, maspardin Neighboring gene ankyrin repeat and death domain containing 1A Neighboring gene STARR-seq mESC enhancer starr_24454 Neighboring gene predicted gene, 17749

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mitochondrial methionyl N-formylation affects steady-state levels of oxidative phosphorylation complexes and their organization into supercomplexes. Arguello T, et al. J Biol Chem, 2018 Sep 28. PMID 30087118, Free PMC Article
  2. Cre recombinase activity is inhibited in vivo but not ex vivo by a mutation in the asymmetric spacer region of the distal loxP site. Arguello T, et al. Genesis, 2015 Nov. PMID 26331883, Free PMC Article
  3. Mitochondrial Methionyl-tRNA Formyltransferase Deficiency Alleviates Metaflammation by Modulating Mitochondrial Activity in Mice. Sun X, et al. Int J Mol Sci, 2023 Mar 22. PMID 36983072, Free PMC Article
  4. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mitochondrial Methionyl-tRNA Formyltransferase Deficiency Alleviates Metaflammation by Modulating Mitochondrial Activity in Mice.
    Title: Mitochondrial Methionyl-tRNA Formyltransferase Deficiency Alleviates Metaflammation by Modulating Mitochondrial Activity in Mice.
  2. Here, we generated a Mtfmt-KO mouse fibroblast cell line and demonstrated that N-formylation of the first methionine via fMet-tRNA(Met) by MTFMT is not an absolute requirement for initiation of protein synthesis.
    Title: Mitochondrial methionyl N-formylation affects steady-state levels of oxidative phosphorylation complexes and their organization into supercomplexes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables methionyl-tRNA formyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methionyl-tRNA formyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
methionyl-tRNA formyltransferase, mitochondrial
NP_081410.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027134.3 → NP_081410.2  methionyl-tRNA formyltransferase, mitochondrial

    See identical proteins and their annotated locations for NP_081410.2

    Status: VALIDATED

    Source sequence(s)
    AK009430, AK133492
    Consensus CDS
    CCDS23292.1
    UniProtKB/Swiss-Prot
    E9QKZ0, Q8VE89, Q9D799
    UniProtKB/TrEMBL
    Q3V021
    Related
    ENSMUSP00000074347.7, ENSMUST00000074792.7
    Conserved Domains (3) summary
    cd08646
    Location:43 → 239
    FMT_core_Met-tRNA-FMT_N; Methionyl-tRNA formyltransferase, N-terminal hydrolase domain
    TIGR00460
    Location:31 → 353
    fmt; methionyl-tRNA formyltransferase
    cl14785
    Location:243 → 343
    FMT_C_like; Carboxy-terminal domain of Formyltransferase and similar domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    65343064..65360336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D799.3 GenPept UniProtKB/Swiss-Prot:Q9D799

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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