tbk1 TANK-binding kinase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tbk1provided by ZNC
Official Full Name: TANK-binding kinase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-060512-359
See related: Ensembl:ENSDARG00000103095 AllianceGenome:ZFIN:ZDB-GENE-060512-359
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fk70c05; zgc:136548
Summary: Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within negative regulation of type I interferon production. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in brain disease and frontotemporal dementia and/or amyotrophic lateral sclerosis-4. Orthologous to human TBK1 (TANK binding kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (134409..149334, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (120079..135001)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Histone H2A Nuclear/Cytoplasmic Trafficking Is Essential for Negative Regulation of Antiviral Immune Response and Lysosomal Degradation of TBK1 and IRF3.
Title: Histone H2A Nuclear/Cytoplasmic Trafficking Is Essential for Negative Regulation of Antiviral Immune Response and Lysosomal Degradation of TBK1 and IRF3.
Zebrafish FGFR3 is a negative regulator of interferon (IFN) production in the innate immune response by suppressing the activity of TANK-binding kinase 1 (TBK1) in the process of virus infection.
Title: Zebrafish FGFR3 is a negative regulator of RLR pathway to decrease IFN expression.
this study shows that STAT6 negatively regulates IFNphi1 production by attenuating the kinase activity of TANK-binding kinase 1
Title: Zebrafish STAT6 negatively regulates IFNφ1 production by attenuating the kinase activity of TANK-binding kinase 1.
Fish IRF6 is distinguished from the homolog of mammals by being a positive regulator of IFN transcription and phosphorylated by MyD88 and TBK1, suggesting that differences in the IRF6 regulation pattern exist between lower and higher vertebrates.
Title: Fish IRF6 is a positive regulator of IFN expression and involved in both of the MyD88 and TBK1 pathways.

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General gene information

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Markers

fk31f11.x1 (e-PCR)
- UniSTS:200807

fl05f06.x1 (e-PCR)
- UniSTS:201902

fk70c05.x1 (e-PCR)
- UniSTS:201441

fk56e12.x1 (e-PCR)
- UniSTS:201209

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of type I interferon production	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of response to stimulus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine/threonine-protein kinase TBK1

NP_001038213.2

EC 2.7.11.1

XP_021330815.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044748.2 → NP_001038213.2 serine/threonine-protein kinase TBK1

See identical proteins and their annotated locations for NP_001038213.2

Status: VALIDATED

Source sequence(s)

DQ860098, FP017216, FP245483

UniProtKB/TrEMBL

A0A8M1N974, Q0GKD6

Related

ENSDARP00000132718.1, ENSDART00000163280.3

Conserved Domains (2) summary

cd12219
Location:297 → 385

UBL_TBK1_like; Ubiquitin-Like Domain Of Human Tbk1 and similar proteins

cd13988
Location:15 → 330

STKc_TBK1; Catalytic domain of the Serine/Threonine kinase, TANK Binding Kinase 1

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007115.7 Reference GRCz11 Primary Assembly

Range

134409..149334 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021475140.1 → XP_021330815.1 serine/threonine-protein kinase TBK1 isoform X1

UniProtKB/TrEMBL

A0A8M1N974, Q0GKD6

Conserved Domains (2) summary

cd12219
Location:297 → 385

UBL_TBK1_like; Ubiquitin-Like Domain Of Human Tbk1 and similar proteins

cd13988
Location:15 → 330

STKc_TBK1; Catalytic domain of the Serine/Threonine kinase, TANK Binding Kinase 1