Rdh8 retinol dehydrogenase 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rdh8provided by RGD
Official Full Name: retinol dehydrogenase 8provided by RGD
Primary source: RGD:1589829
See related: Ensembl:ENSRNOG00000025767 AllianceGenome:RGD:1589829
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable NAD-retinol dehydrogenase activity. Predicted to be involved in estrogen biosynthetic process. Predicted to act upstream of or within retinol metabolic process and visual perception. Predicted to be located in cytoplasm and membrane. Orthologous to human RDH8 (retinol dehydrogenase 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 15.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 8q13

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (27629380..27636651)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (19353191..19360462)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (21835065..21842374)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables all-trans-retinol dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables all-trans-retinol dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables all-trans-retinol dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in estrogen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in retinol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within retinol metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within visual perception	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: retinol dehydrogenase 8

Names: retinol dehydrogenase 8 (all-trans)

NP_001162065.1

EC 1.1.1.300

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.