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Nrg4 neuregulin 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 690919, updated on 13-Apr-2024

Summary

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Official Symbol
Nrg4provided by RGD
Official Full Name
neuregulin 4provided by RGD
Primary source
RGD:1589860
See related
Ensembl:ENSRNOG00000015149 AllianceGenome:RGD:1589860
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable signaling receptor binding activity. Predicted to be involved in nervous system development. Predicted to be integral component of membrane. Orthologous to human NRG4 (neuregulin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 71.8), Adrenal (RPKM 39.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
8q24
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (64483559..64555671, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (55586253..55677829, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (59782789..59849433, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094166 Neighboring gene cholinergic receptor nicotinic beta 4 subunit Neighboring gene ubiquitin conjugating enzyme E2 Q2 Neighboring gene F-box protein 22 Neighboring gene uncharacterized LOC134480177 Neighboring gene uncharacterized LOC134480176 Neighboring gene Serpine1 mRNA binding protein 1, pseudogene 1 Neighboring gene F-box/LRR-repeat protein 14-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cardioprotective effect of NRG-4 gene expression on spontaneous hypertension rats and its mechanism through mediating the activation of ErbB signaling pathway. Yang Z, et al. Cell Mol Biol (Noisy-le-grand), 2022 May 22. PMID 35809324
  2. Localization of HRG4, a photoreceptor protein homologous to Unc-119, in ribbon synapse. Higashide T, et al. Invest Ophthalmol Vis Sci, 1998 Apr. PMID 9538874
  3. Neuregulins and cancer. Montero JC, et al. Clin Cancer Res, 2008 Jun 1. PMID 18519747
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. [Electroacupuncture intervention improves lipid metabolism and promotes browning of white adipose tissue by activating AMPK/Sirt1 pathway and up-regulating Nrg4 content in middle-aged and aged obese rats].
    Title: [Electroacupuncture intervention improves lipid metabolism and promotes browning of white adipose tissue by activating AMPK/Sirt1 pathway and up-regulating Nrg4 content in middle-aged and aged obese rats].
  2. Cardioprotective effect of NRG-4 gene expression on spontaneous hypertension rats and its mechanism through mediating the activation of ErbB signaling pathway.
    Title: Cardioprotective effect of NRG-4 gene expression on spontaneous hypertension rats and its mechanism through mediating the activation of ErbB signaling pathway.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ERBB4-ERBB4 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pro-neuregulin-4, membrane-bound isoform

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191109.3 → NP_001178038.1  pro-neuregulin-4, membrane-bound isoform

    See identical proteins and their annotated locations for NP_001178038.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6J4P4, F1M0L6
    Related
    ENSRNOP00000020332.6, ENSRNOT00000020332.6
    Conserved Domains (1) summary
    PHA03099
    Location:9 → 82
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    64483559..64555671 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082177.2 → XP_038938105.2  pro-neuregulin-4, membrane-bound isoform isoform X1

  2. XM_063266174.1 → XP_063122244.1  pro-neuregulin-4, membrane-bound isoform isoform X2

  3. XM_063266175.1 → XP_063122245.1  pro-neuregulin-4, membrane-bound isoform isoform X3

  4. XM_063266172.1 → XP_063122242.1  pro-neuregulin-4, membrane-bound isoform isoform X1

  5. XM_063266173.1 → XP_063122243.1  pro-neuregulin-4, membrane-bound isoform isoform X1

  6. XM_039082178.2 → XP_038938106.2  pro-neuregulin-4, membrane-bound isoform isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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