Hcar1 hydroxycarboxylic acid receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hcar1provided by RGD
Official Full Name: hydroxycarboxylic acid receptor 1provided by RGD
Primary source: RGD:1586364
See related: Ensembl:ENSRNOG00000026661 AllianceGenome:RGD:1586364
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gpr81
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and negative regulation of lipid catabolic process. Predicted to be integral component of membrane. Predicted to be active in membrane. Orthologous to human HCAR1 (hydroxycarboxylic acid receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: 12q15

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (38371593..38374847)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (32710680..32713934)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (38145177..38146232)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of GPR81 in regulating intramuscular triglyceride storage during aerobic exercise in rats.
Title: Role of GPR81 in regulating intramuscular triglyceride storage during aerobic exercise in rats.
Activation of lactate receptor HCAR1 down-modulates neuronal activity in rodent and human brain tissue.
Title: Activation of lactate receptor HCAR1 down-modulates neuronal activity in rodent and human brain tissue.
Adiposederived mesenchymal stem cellderived HCAR1 regulates immune response in the attenuation of sepsis.
Title: Adipose‑derived mesenchymal stem cell‑derived HCAR1 regulates immune response in the attenuation of sepsis.
Differential effects of L- and D-lactate on memory encoding and consolidation: Potential role of HCAR1 signaling.
Title: Differential effects of L- and D-lactate on memory encoding and consolidation: Potential role of HCAR1 signaling.
Results indicate that lactate may aggravated ischemic brain injury by activating GPR81 and inhibition of GPR81 protects against ischemia-induced cell death via an antiapoptosis pathway
Title: Inhibition of G protein-coupled receptor 81 (GPR81) protects against ischemic brain injury.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: hydroxycarboxylic acid receptor 1

Names: G protein-coupled receptor 81

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.