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Phkg2 phosphorylase kinase, gamma 2 (testis) [ Mus musculus (house mouse) ]

Gene ID: 68961, updated on 11-Apr-2024

Summary

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Official Symbol
Phkg2provided by MGI
Official Full Name
phosphorylase kinase, gamma 2 (testis)provided by MGI
Primary source
MGI:MGI:1916211
See related
Ensembl:ENSMUSG00000030815 AllianceGenome:MGI:1916211
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500017I02Rik
Summary
Predicted to enable several functions, including ATP binding activity; calmodulin binding activity; and phosphorylase kinase activity. Predicted to be involved in glycogen metabolic process and protein phosphorylation. Predicted to act upstream of or within carbohydrate metabolic process and phosphorylation. Predicted to be located in cytosol. Predicted to be part of phosphorylase kinase complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in glycogen storage disease; glycogen storage disease IXc; and liver cirrhosis. Orthologous to human PHKG2 (phosphorylase kinase catalytic subunit gamma 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 599.3) and thymus adult (RPKM 26.5) See more
Orthologs
human all
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Genomic context

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Location:
7 F3; 7 69.6 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127169252..127182479)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127573345..127583307)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Snf2-related CREBBP activator protein Neighboring gene small nucleolar RNA, H/ACA box 30 Neighboring gene transmembrane protein 265 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134716729-134716937 Neighboring gene STARR-positive B cell enhancer ABC_E6607 Neighboring gene cilia and flagella associated protein 119 Neighboring gene ring finger protein 40

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of liver GSD IX γ2 pathophysiology in a novel Phkg2(-/-) mouse model. Gibson RA, et al. Mol Genet Metab, 2021 Jul. PMID 34083142, Free PMC Article
  2. Elucidation of the molecular mechanisms underlying adverse reactions associated with a kinase inhibitor using systems toxicology. Amemiya T, et al. NPJ Syst Biol Appl, 2015. PMID 28725458, Free PMC Article
  3. Circular RNA profile in liver tissue of EpCAM knockout mice. Yang Y, et al. Int J Mol Med, 2019 Sep. PMID 31524221, Free PMC Article
  4. Analysis of a lung defect in autophagy-deficient mouse strains. Cheong H, et al. Autophagy, 2014 Jan. PMID 24275123, Free PMC Article
  5. Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series. Bowman CE, et al. Mol Cell Biol, 2016 Aug 1. PMID 27215380, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphorylase kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphorylase kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycogen metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of glycogen catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of phosphorylase kinase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phosphorylase b kinase gamma catalytic chain, liver/testis isoform
Names
PHK-gamma-LT
PHK-gamma-T
phosphorylase kinase subunit gamma-2
serine/threonine-protein kinase PHKG2
NP_001347670.1
NP_081164.2
XP_006508230.1
XP_006508231.1
XP_006508232.1
XP_030098816.1
XP_030098817.1
XP_030098818.1
XP_030098819.1
XP_036009301.1
XP_036009302.1
XP_036009303.1
XP_036009304.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360741.1 → NP_001347670.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction and lacks an alternate exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC122417
    Conserved Domains (1) summary
    cl21453
    Location:1 → 182
    PKc_like; Protein Kinases, catalytic domain

  2. NM_026888.3 → NP_081164.2  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform 1

    See identical proteins and their annotated locations for NP_081164.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA198694, AK005277, AK079680, BQ176174
    Consensus CDS
    CCDS21869.1
    UniProtKB/Swiss-Prot
    A6H632, Q9DB30
    Related
    ENSMUSP00000033086.2, ENSMUST00000033086.8
    Conserved Domains (1) summary
    cl21453
    Location:13 → 291
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    127169252..127182479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153408.1 → XP_036009301.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1

    UniProtKB/Swiss-Prot
    A6H632, Q9DB30
    Related
    ENSMUSP00000113533.2, ENSMUST00000121004.3
    Conserved Domains (1) summary
    cl21453
    Location:13 → 291
    PKc_like; Protein Kinases, catalytic domain

  2. XM_036153410.1 → XP_036009303.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:1 → 189
    PKc_like; Protein Kinases, catalytic domain

  3. XM_006508167.4 → XP_006508230.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1

    See identical proteins and their annotated locations for XP_006508230.1

    UniProtKB/Swiss-Prot
    A6H632, Q9DB30
    Conserved Domains (1) summary
    cl21453
    Location:13 → 291
    PKc_like; Protein Kinases, catalytic domain

  4. XM_030242958.1 → XP_030098818.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1 → 182
    PKc_like; Protein Kinases, catalytic domain

  5. XM_030242957.1 → XP_030098817.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:1 → 189
    PKc_like; Protein Kinases, catalytic domain

  6. XM_036153411.1 → XP_036009304.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:1 → 189
    PKc_like; Protein Kinases, catalytic domain

  7. XM_006508168.3 → XP_006508231.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X2

    See identical proteins and their annotated locations for XP_006508231.1

    Conserved Domains (1) summary
    cl21453
    Location:10 → 194
    PKc_like; Protein Kinases, catalytic domain

  8. XM_030242956.1 → XP_030098816.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:1 → 189
    PKc_like; Protein Kinases, catalytic domain

  9. XM_006508169.4 → XP_006508232.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X2

    See identical proteins and their annotated locations for XP_006508232.1

    Conserved Domains (1) summary
    cl21453
    Location:10 → 194
    PKc_like; Protein Kinases, catalytic domain

  10. XM_036153409.1 → XP_036009302.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:10 → 194
    PKc_like; Protein Kinases, catalytic domain

  11. XM_030242959.1 → XP_030098819.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1 → 182
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DB30.2 GenPept UniProtKB/Swiss-Prot:Q9DB30

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