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Mapk11 mitogen-activated protein kinase 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 689314, updated on 5-Mar-2024

Summary

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Official Symbol
Mapk11provided by RGD
Official Full Name
mitogen-activated protein kinase 11provided by RGD
Primary source
RGD:1309340
See related
Ensembl:ENSRNOG00000006984 AllianceGenome:RGD:1309340
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
p38beta
Summary
Enables ATP binding activity and MAP kinase activity. Involved in protein phosphorylation. Predicted to be active in cytosol and nucleus. Orthologous to human MAPK11 (mitogen-activated protein kinase 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 67.3), Lung (RPKM 23.0) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mapk11 in Genome Data Viewer
Location:
7q34
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (122098120..122105023, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (120218471..120225488, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (130121678..130129199, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene histone deacetylase 10 Neighboring gene mitogen-activated protein kinase 12 Neighboring gene uncharacterized LOC108351526 Neighboring gene plexin B2 Neighboring gene microRNA 349 Neighboring gene DENN domain containing 6B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mitochondrial p38β and manganese superoxide dismutase interaction mediated by estrogen in cardiomyocytes. Liu H, et al. PLoS One, 2014. PMID 24465521, Free PMC Article
  2. p38β MAPK affords cytoprotection against oxidative stress-induced astrocyte apoptosis via induction of αB-crystallin and its anti-apoptotic function. Shin JH, et al. Neurosci Lett, 2011 Sep 1. PMID 21777656
  3. Distinct regulation of B-type natriuretic peptide transcription by p38 MAPK isoforms. Koivisto E, et al. Mol Cell Endocrinol, 2011 May 16. PMID 21354263
  4. Role of spinal p38alpha and beta MAPK in inflammatory hyperalgesia and spinal COX-2 expression. Fitzsimmons BL, et al. Neuroreport, 2010 Mar 10. PMID 20134354, Free PMC Article
  5. The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas. Wang S, et al. BMC Endocr Disord, 2021 Nov 23. PMID 34814904, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas.
    Title: The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas.
  2. Data indicate a functionally active mitochondrial pool of p38beta mitogen activated protein kinase (p38beta MAPK), and that this kinase phosphorylates manganese superoxide dismutase (MnSOD) in an 17beta-estradiol (E2)-dependent manner.
    Title: Mitochondrial p38β and manganese superoxide dismutase interaction mediated by estrogen in cardiomyocytes.
  3. p38beta confers protection against hydrogen peroxide (HO)-induced astrocyte apoptosis by inducing a small heat shock protein, alphaB-crystallin, which inhibits caspase-3 activation.
    Title: p38β MAPK affords cytoprotection against oxidative stress-induced astrocyte apoptosis via induction of αB-crystallin and its anti-apoptotic function.
  4. Overexpression of p38beta or Rac1 significantly enhanced (1.9- and 3.9-fold, respectively), the tRA-stimulated NIS expression in MCF-7 cells.
    Title: Regulation of sodium iodide symporter gene expression by Rac1/p38β mitogen-activated protein kinase signaling pathway in MCF-7 breast cancer cells.
  5. p38beta-induced B-natriuretic peptide transcription was mediated by a GATA-4 transcription factor binding site.
    Title: Distinct regulation of B-type natriuretic peptide transcription by p38 MAPK isoforms.
  6. Data shwo that hyperalgesia is prevented by downregulation of p38beta but not p38alpha, whereas increases in spinal COX-2 protein expression at 8 hours are mediated by both p38alpha and beta isoforms.
    Title: Role of spinal p38alpha and beta MAPK in inflammatory hyperalgesia and spinal COX-2 expression.
  7. in intestinal epithelial cells, Ang II-dependent activation of the COX-2 promoter is mediated primarily through Gq/11 signaling via a PAK/MKK6/Mapk11/CREB signaling cascade
    Title: COX-2 promoter activation by AT1R-Gq-PAK-p38beta signaling in intestinal epithelial cells.
  8. unique ceramide signaling in ischemic and preconditioned hearts involving lipid rafts, which generated a survival signal by differentially associating the p38MAPKalpha and p38MAPKbeta with the caveolin-1 and caveoli-3
    Title: Generation of survival signal by differential interaction of p38MAPKalpha and p38MAPKbeta with caveolin-1 and caveolin-3 in the adapted heart.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC187942

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables MAP kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables MAP kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in bone development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to UV-B ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in positive regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in stress-activated protein kinase signaling cascade ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase 11
NP_001103002.2
XP_017450608.1
XP_038935846.1
XP_038935847.1
XP_063120345.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109532.2 → NP_001103002.2  mitogen-activated protein kinase 11

    See identical proteins and their annotated locations for NP_001103002.2

    Status: PROVISIONAL

    Source sequence(s)
    CH474027
    UniProtKB/TrEMBL
    A0A0G2KB06, A0A8I6G769, A6K7K4
    Related
    ENSRNOP00000075602.1, ENSRNOT00000079777.2
    Conserved Domains (1) summary
    cl21453
    Location:8 → 350
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    122098120..122105023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017595119.3 → XP_017450608.1  mitogen-activated protein kinase 11 isoform X1

    UniProtKB/TrEMBL
    A0A8I6G769, B1WC76, D4A3U7
    Related
    ENSRNOP00000009325.6

  2. XM_063264275.1 → XP_063120345.1  mitogen-activated protein kinase 11 isoform X2

  3. XM_039079918.2 → XP_038935846.1  mitogen-activated protein kinase 11 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:8 → 234
    PKc_like; Protein Kinases, catalytic domain

  4. XM_039079919.2 → XP_038935847.1  mitogen-activated protein kinase 11 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:8 → 210
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version

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