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Afmid arylformamidase [ Rattus norvegicus (Norway rat) ]

Gene ID: 688283, updated on 5-Mar-2024

Summary

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Official Symbol
Afmidprovided by RGD
Official Full Name
arylformamidaseprovided by RGD
Primary source
RGD:1591143
See related
Ensembl:ENSRNOG00000050205 AllianceGenome:RGD:1591143
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable hydrolase activity. Predicted to be involved in tryptophan catabolic process to kynurenine. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Orthologous to human AFMID (arylformamidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 253.1), Kidney (RPKM 192.1) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q32.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (103544822..103560408)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (103046129..103061718)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (106828963..106844314)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene synaptogyrin 2 Neighboring gene thymidine kinase 1 Neighboring gene uncharacterized LOC102548046 Neighboring gene baculoviral IAP repeat-containing 5 Neighboring gene transmembrane protein 235

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Alternate activation of two divergently transcribed mouse genes from a bidirectional promoter is linked to changes in histone modification. Schuettengruber B, et al. J Biol Chem, 2003 Jan 17. PMID 12411446
  2. Effect of arylformamidase (kynurenine formamidase) gene inactivation in mice on enzymatic activity, kynurenine pathway metabolites and phenotype. Dobrovolsky VN, et al. Biochim Biophys Acta, 2005 Jun 20. PMID 15866519
  3. The kynurenine pathway and neurodegenerative disease. Maddison DC, et al. Semin Cell Dev Biol, 2015 Apr. PMID 25773161
  4. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables arylformamidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' NAD biosynthetic process from tryptophan IEA
Inferred from Electronic Annotation
more info
  
involved_in tryptophan catabolic process to kynurenine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tryptophan catabolic process to kynurenine IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tryptophan catabolic process to kynurenine ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kynurenine formamidase
NP_001104836.1
XP_006247885.1
XP_017453019.1
XP_063125935.1
XP_063125936.1
XP_063125937.1
XP_063125938.1
XP_063125940.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111366.1 → NP_001104836.1  kynurenine formamidase

    See identical proteins and their annotated locations for NP_001104836.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A0A8I6GH15, A6HL34, M0RC77
    Related
    ENSRNOP00000067187.1, ENSRNOT00000073809.2
    Conserved Domains (2) summary
    COG0657
    Location:56 → 298
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    cl21494
    Location:90 → 280
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    103544822..103560408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597530.3 → XP_017453019.1  kynurenine formamidase isoform X2

    UniProtKB/TrEMBL
    A0A8I6GH15

  2. XM_006247823.5 → XP_006247885.1  kynurenine formamidase isoform X3

    UniProtKB/TrEMBL
    A0A8I6GH15
    Conserved Domains (2) summary
    COG0657
    Location:56 → 261
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    cl21494
    Location:90 → 261
    Abhydrolase; alpha/beta hydrolases

  3. XM_063269865.1 → XP_063125935.1  kynurenine formamidase isoform X1

  4. XM_063269867.1 → XP_063125937.1  kynurenine formamidase isoform X4

  5. XM_063269868.1 → XP_063125938.1  kynurenine formamidase isoform X5

  6. XM_063269870.1 → XP_063125940.1  kynurenine formamidase isoform X6

  7. XM_063269866.1 → XP_063125936.1  kynurenine formamidase isoform X4

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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