Sorbs1 sorbin and SH3 domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sorbs1provided by RGD
Official Full Name: sorbin and SH3 domain containing 1provided by RGD
Primary source: RGD:1586598
See related: Ensembl:ENSRNOG00000015658 AllianceGenome:RGD:1586598
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CAP; SH3P12
Summary: Enables insulin receptor binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including response to activity; response to insulin; and response to monosodium L-glutamate. Located in plasma membrane. Part of insulin receptor complex. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human SORBS1 (sorbin and SH3 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 576.8), Muscle (RPKM 112.2) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (249057324..249279703, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (239107882..239330276, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (259373921..259502108, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BM390792 (e-PCR)
- UniSTS:260876

BF390449 (e-PCR)
- UniSTS:249471

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables insulin receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables insulin receptor binding	IEA Inferred from Electronic Annotation more info
enables insulin receptor binding	ISO Inferred from Sequence Orthology more info
enables insulin receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor complex adaptor activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor complex adaptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within acetylcholine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in focal adhesion assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of glucose import	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glucose import	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of glycogen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of lipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of skeletal muscle acetylcholine-gated channel clustering	ISO Inferred from Sequence Orthology more info
involved_in response to L-glutamate	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info
involved_in response to starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in stress fiber assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in adherens junction	ISS Inferred from Sequence or Structural Similarity more info
located_in cell-substrate junction	ISO Inferred from Sequence Orthology more info
located_in cell-substrate junction	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of flotillin complex	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
part_of insulin receptor complex	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info
located_in stress fiber	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sorbin and SH3 domain-containing protein 1

Names: Cbl associated protein; ponsin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001421361.1 → NP_001408290.1 sorbin and SH3 domain-containing protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

249057324..249279703 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063273987.1 → XP_063130057.1 sorbin and SH3 domain-containing protein 1 isoform X4
XM_063273958.1 → XP_063130028.1 sorbin and SH3 domain-containing protein 1 isoform X1
XM_063273968.1 → XP_063130038.1 sorbin and SH3 domain-containing protein 1 isoform X4
XM_063273962.1 → XP_063130032.1 sorbin and SH3 domain-containing protein 1 isoform X2
XM_063273977.1 → XP_063130047.1 sorbin and SH3 domain-containing protein 1 isoform X4
XM_063273964.1 → XP_063130034.1 sorbin and SH3 domain-containing protein 1 isoform X2
XM_063273954.1 → XP_063130024.1 sorbin and SH3 domain-containing protein 1 isoform X1
XM_063273944.1 → XP_063130014.1 sorbin and SH3 domain-containing protein 1 isoform X1
XM_063273951.1 → XP_063130021.1 sorbin and SH3 domain-containing protein 1 isoform X1
XM_039095037.2 → XP_038950965.1 sorbin and SH3 domain-containing protein 1 isoform X3

Conserved Domains (4) summary

cd11916
Location:1987 → 2045

SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cd11919
Location:1557 → 1611

SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cd11922
Location:1631 → 1688

SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cl02617
Location:643 → 683

Sorb; Sorbin homologous domain
XM_063273997.1 → XP_063130067.1 sorbin and SH3 domain-containing protein 1 isoform X9
XM_063273996.1 → XP_063130066.1 sorbin and SH3 domain-containing protein 1 isoform X8
XM_063274002.1 → XP_063130072.1 sorbin and SH3 domain-containing protein 1 isoform X10
XM_063273992.1 → XP_063130062.1 sorbin and SH3 domain-containing protein 1 isoform X6
XM_063274018.1 → XP_063130088.1 sorbin and SH3 domain-containing protein 1 isoform X12
XM_063273994.1 → XP_063130064.1 sorbin and SH3 domain-containing protein 1 isoform X7
XM_063274047.1 → XP_063130117.1 sorbin and SH3 domain-containing protein 1 isoform X17
XM_063274026.1 → XP_063130096.1 sorbin and SH3 domain-containing protein 1 isoform X13
XM_063274011.1 → XP_063130081.1 sorbin and SH3 domain-containing protein 1 isoform X11
XM_063274053.1 → XP_063130123.1 sorbin and SH3 domain-containing protein 1 isoform X18
XM_063274030.1 → XP_063130100.1 sorbin and SH3 domain-containing protein 1 isoform X14
XM_063274034.1 → XP_063130104.1 sorbin and SH3 domain-containing protein 1 isoform X15
XM_063274037.1 → XP_063130107.1 sorbin and SH3 domain-containing protein 1 isoform X16
XM_063274059.1 → XP_063130129.1 sorbin and SH3 domain-containing protein 1 isoform X19
XM_063274072.1 → XP_063130142.1 sorbin and SH3 domain-containing protein 1 isoform X23
XM_063274069.1 → XP_063130139.1 sorbin and SH3 domain-containing protein 1 isoform X22
XM_063274112.1 → XP_063130182.1 sorbin and SH3 domain-containing protein 1 isoform X34
XM_063274095.1 → XP_063130165.1 sorbin and SH3 domain-containing protein 1 isoform X29
XM_063274063.1 → XP_063130133.1 sorbin and SH3 domain-containing protein 1 isoform X20
XM_039095225.2 → XP_038951153.1 sorbin and SH3 domain-containing protein 1 isoform X43

UniProtKB/TrEMBL

F1M866

Conserved Domains (4) summary

cd11916
Location:1217 → 1275

SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cd11919
Location:1038 → 1092

SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cd11922
Location:1112 → 1169

SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cl02617
Location:613 → 653

Sorb; Sorbin homologous domain
XM_039095212.2 → XP_038951140.1 sorbin and SH3 domain-containing protein 1 isoform X37

UniProtKB/TrEMBL

A0A8I6ASS7

Related

ENSRNOP00000021114.6

Conserved Domains (5) summary

cd11916
Location:1256 → 1314

SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cd11919
Location:826 → 880

SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cd11922
Location:900 → 957

SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

PHA03307
Location:15 → 399

PHA03307; transcriptional regulator ICP4; Provisional

cl02617
Location:401 → 441

Sorb; Sorbin homologous domain
XM_063274119.1 → XP_063130189.1 sorbin and SH3 domain-containing protein 1 isoform X36
XM_063274100.1 → XP_063130170.1 sorbin and SH3 domain-containing protein 1 isoform X31
XM_063274089.1 → XP_063130159.1 sorbin and SH3 domain-containing protein 1 isoform X27
XM_063274083.1 → XP_063130153.1 sorbin and SH3 domain-containing protein 1 isoform X25
XM_039095140.2 → XP_038951068.1 sorbin and SH3 domain-containing protein 1 isoform X21

UniProtKB/TrEMBL

F1M866

Conserved Domains (4) summary

cd11916
Location:1247 → 1305

SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cd11919
Location:1068 → 1122

SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cd11922
Location:1142 → 1199

SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cl02617
Location:643 → 683

Sorb; Sorbin homologous domain
XM_063274125.1 → XP_063130195.1 sorbin and SH3 domain-containing protein 1 isoform X38
XM_063274118.1 → XP_063130188.1 sorbin and SH3 domain-containing protein 1 isoform X35
XM_039095158.2 → XP_038951086.1 sorbin and SH3 domain-containing protein 1 isoform X30

UniProtKB/TrEMBL

F1M866

Conserved Domains (4) summary

smart00459
Location:639 → 684

Sorb; Sorbin homologous domain

cd11916
Location:1187 → 1245

SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cd11919
Location:988 → 1042

SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cd11922
Location:1062 → 1119

SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
XM_039095147.2 → XP_038951075.1 sorbin and SH3 domain-containing protein 1 isoform X24

UniProtKB/TrEMBL

F1M866

Related

ENSRNOP00000021225.5

Conserved Domains (4) summary

cd11916
Location:1226 → 1284

SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cd11919
Location:1047 → 1101

SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cd11922
Location:1121 → 1178

SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cl02617
Location:643 → 683

Sorb; Sorbin homologous domain
XM_039095156.2 → XP_038951084.1 sorbin and SH3 domain-containing protein 1 isoform X28

UniProtKB/TrEMBL

F1M866

Conserved Domains (4) summary

cd11916
Location:1191 → 1249

SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cd11919
Location:1012 → 1066

SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cd11922
Location:1086 → 1143

SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cl02617
Location:643 → 683

Sorb; Sorbin homologous domain
XM_039095228.2 → XP_038951156.1 sorbin and SH3 domain-containing protein 1 isoform X44

UniProtKB/TrEMBL

F1M866

Conserved Domains (4) summary

cd11916
Location:1182 → 1240

SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cd11919
Location:1003 → 1057

SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cd11922
Location:1077 → 1134

SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cl02617
Location:634 → 674

Sorb; Sorbin homologous domain
XM_039095216.2 → XP_038951144.1 sorbin and SH3 domain-containing protein 1 isoform X39

UniProtKB/TrEMBL

A0A8I6ASS7

Related

ENSRNOP00000097497.1

Conserved Domains (5) summary

smart00459
Location:397 → 442

Sorb; Sorbin homologous domain

cd11916
Location:1230 → 1288

SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cd11919
Location:780 → 834

SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cd11922
Location:854 → 911

SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

PHA03307
Location:15 → 399

PHA03307; transcriptional regulator ICP4; Provisional
XM_039095161.2 → XP_038951089.1 sorbin and SH3 domain-containing protein 1 isoform X32

UniProtKB/TrEMBL

F1M866

Conserved Domains (4) summary

smart00459
Location:639 → 684

Sorb; Sorbin homologous domain

cd11916
Location:1179 → 1237

SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cd11919
Location:1000 → 1054

SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cd11922
Location:1074 → 1131

SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
XM_039095154.2 → XP_038951082.1 sorbin and SH3 domain-containing protein 1 isoform X26

UniProtKB/TrEMBL

F1M866

Conserved Domains (4) summary

smart00459
Location:639 → 684

Sorb; Sorbin homologous domain

cd11916
Location:1201 → 1259

SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cd11919
Location:1022 → 1076

SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cd11922
Location:1096 → 1153

SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
XM_039095169.2 → XP_038951097.1 sorbin and SH3 domain-containing protein 1 isoform X33

UniProtKB/TrEMBL

F1M866

Conserved Domains (4) summary

cd11916
Location:1170 → 1228

SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cd11919
Location:991 → 1045

SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cd11922
Location:1065 → 1122

SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cl02617
Location:643 → 683

Sorb; Sorbin homologous domain
XM_063274132.1 → XP_063130202.1 sorbin and SH3 domain-containing protein 1 isoform X40
XM_063274133.1 → XP_063130203.1 sorbin and SH3 domain-containing protein 1 isoform X42
XM_039095220.2 → XP_038951148.1 sorbin and SH3 domain-containing protein 1 isoform X41

Conserved Domains (4) summary

cd11916
Location:975 → 1033

SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cd11919
Location:796 → 850

SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cd11922
Location:870 → 927

SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

cl02617
Location:392 → 432

Sorb; Sorbin homologous domain
XM_063273991.1 → XP_063130061.1 sorbin and SH3 domain-containing protein 1 isoform X5