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Atp6v1a ATPase H+ transporting V1 subunit A [ Rattus norvegicus (Norway rat) ]

Gene ID: 685232, updated on 13-Apr-2024

Summary

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Official Symbol
Atp6v1aprovided by RGD
Official Full Name
ATPase H+ transporting V1 subunit Aprovided by RGD
Primary source
RGD:1596464
See related
Ensembl:ENSRNOG00000001992 AllianceGenome:RGD:1596464
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Atp6v1a1
Summary
Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in cellular iron ion homeostasis; cellular response to increased oxygen levels; and proton transmembrane transport. Predicted to be located in several cellular components, including apical plasma membrane; microvillus; and secretory granule. Predicted to be part of vacuolar proton-transporting V-type ATPase, V1 domain. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IID and developmental and epileptic encephalopathy 93. Orthologous to human ATP6V1A (ATPase H+ transporting V1 subunit A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 766.9), Kidney (RPKM 593.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
11q21
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (70066800..70120603)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (56561444..56614694)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (61531386..61584634)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene upstream transcription factor family member 3 Neighboring gene uncharacterized LOC120095658 Neighboring gene N(alpha)-acetyltransferase 50, NatE catalytic subunit Neighboring gene uncharacterized LOC134481070 Neighboring gene GRAM domain containing 1C Neighboring gene zinc finger DHHC-type palmitoyltransferase 23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Vacuolar ATPase regulates surfactant secretion in rat alveolar type II cells by modulating lamellar body calcium. Chintagari NR, et al. PLoS One, 2010 Feb 16. PMID 20169059, Free PMC Article
  2. Interaction of dynamin I with NAP-22, a neuronal protein enriched in the presynaptic region. Ueno S, et al. Neurosci Lett, 2018 May 14. PMID 29604406
  3. V-ATPase expression in the mouse olfactory epithelium. Paunescu TG, et al. Am J Physiol Cell Physiol, 2008 Oct. PMID 18667600, Free PMC Article
  4. Structure of V-ATPase from the mammalian brain. Abbas YM, et al. Science, 2020 Mar 13. PMID 32165585, Free PMC Article
  5. The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular iron levels. Miles AL, et al. Elife, 2017 Mar 15. PMID 28296633, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that silencing of V-ATPase a1 and B2 subunits decreased stimulated surfactant secretion.
    Title: Vacuolar ATPase regulates surfactant secretion in rat alveolar type II cells by modulating lamellar body calcium.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables proton-transporting ATP synthase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
enables proton-transporting ATPase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proton-transporting ATPase activity, rotational mechanism ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ATP metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to increased oxygen levels ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in proton motive force-driven ATP synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle lumen acidification ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of ATPase complex ISO
Inferred from Sequence Orthology
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in clathrin-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in extrinsic component of synaptic vesicle membrane EXP
Inferred from Experiment
more info
 PubMed 
is_active_in extrinsic component of synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in microvillus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of proton-transporting V-type ATPase complex ISO
Inferred from Sequence Orthology
more info
  
part_of proton-transporting V-type ATPase, V1 domain ISO
Inferred from Sequence Orthology
more info
  
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
  
part_of transmembrane transporter complex ISO
Inferred from Sequence Orthology
more info
  
part_of vacuolar proton-transporting V-type ATPase, V1 domain ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
V-type proton ATPase catalytic subunit A
Names
ATPase, H+ transporting, lysosomal V1 subunit A
NP_001101788.1
XP_006248410.1
XP_006248411.1
XP_063126837.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108318.2 → NP_001101788.1  V-type proton ATPase catalytic subunit A

    See identical proteins and their annotated locations for NP_001101788.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A0A1W2Q641, A6IR15
    Related
    ENSRNOP00000002727.6, ENSRNOT00000002727.6
    Conserved Domains (1) summary
    TIGR01042
    Location:17 → 609
    V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    70066800..70120603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270767.1 → XP_063126837.1  V-type proton ATPase catalytic subunit A isoform X1

    UniProtKB/TrEMBL
    A6IR15

  2. XM_006248348.5 → XP_006248410.1  V-type proton ATPase catalytic subunit A isoform X1

    See identical proteins and their annotated locations for XP_006248410.1

    UniProtKB/TrEMBL
    A0A1W2Q641, A6IR15
    Conserved Domains (1) summary
    TIGR01042
    Location:17 → 609
    V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit

  3. XM_006248349.5 → XP_006248411.1  V-type proton ATPase catalytic subunit A isoform X1

    See identical proteins and their annotated locations for XP_006248411.1

    UniProtKB/TrEMBL
    A0A1W2Q641, A6IR15
    Conserved Domains (1) summary
    TIGR01042
    Location:17 → 609
    V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit
Nucleotide Protein Strain
Heading Accession and Version

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