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Itga9 integrin subunit alpha 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 685004, updated on 4-Apr-2024

Summary

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Official Symbol
Itga9provided by RGD
Official Full Name
integrin subunit alpha 9provided by RGD
Primary source
RGD:1311191
See related
Ensembl:ENSRNOG00000043167 AllianceGenome:RGD:1311191
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Itga9l
Summary
Enables collagen binding activity and laminin binding activity. Involved in wound healing. Located in membrane. Part of integrin alpha9-beta1 complex. Human ortholog(s) of this gene implicated in cerebral infarction; hypertension; and pancreatic cancer. Orthologous to human ITGA9 (integrin subunit alpha 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 172.2), Adrenal (RPKM 119.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Itga9 in Genome Data Viewer
Location:
8q32
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (127185244..127493296)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (118307424..118615527)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (127271029..127576709)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene eomesodermin Neighboring gene golgin A4 Neighboring gene transfer RNA alanine (anticodon GGC) 2 Neighboring gene uncharacterized LOC134480111 Neighboring gene uncharacterized LOC134480112 Neighboring gene uncharacterized LOC134480247 Neighboring gene CTD small phosphatase like Neighboring gene transfer RNA glycine (anticodon ACC) 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of tenascin-C and the integrin alpha 9 subunit in regeneration of rat nasal mucosa after chemical injury: involvement in migration and proliferation of epithelial cells. Yoshimura E, et al. Histochem Cell Biol, 1999 Apr. PMID 10219625
  2. [Association of ITGA9 gene rs189897 and rs2212020 genotypes and its haplotype with cerebral infarction]. Li XM, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2011 Jun. PMID 21764681
  3. Purification and characterization of integrin alpha 9 beta 1. Forsberg E, et al. Exp Cell Res, 1994 Jul. PMID 8020590
  4. Interaction of osteopontin with neutrophil alpha(4)beta(1) and alpha(9)beta(1) integrins in a rodent model of alcoholic liver disease. Banerjee A, et al. Toxicol Appl Pharmacol, 2008 Dec 1. PMID 18778724
  5. Localization of integrin beta 1, alpha 1, alpha 5 and alpha 9 subunits in the rat testis. Giebel J, et al. Int J Androl, 1997 Feb. PMID 9202984

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables collagen binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables integrin binding involved in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
  
enables laminin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrin alpha9-beta1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of integrin alpha9-beta1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
integrin alpha-9
Names
integrin, alpha 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420002.2 → NP_001406931.1  integrin alpha-9 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    D3ZN51
    Related
    ENSRNOP00000015113.8, ENSRNOT00000015113.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    127185244..127493296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266145.1 → XP_063122215.1  integrin alpha-9 isoform X3

  2. XM_039082700.2 → XP_038938628.1  integrin alpha-9 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GL49, A6I3U4
    Related
    ENSRNOP00000094362.1
    Conserved Domains (2) summary
    smart00191
    Location:309 → 362
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:407 → 851
    Integrin_alpha2; Integrin alpha

  3. XM_039082701.2 → XP_038938629.1  integrin alpha-9 isoform X2

    UniProtKB/TrEMBL
    A6I3U4
    Conserved Domains (2) summary
    smart00191
    Location:260 → 313
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:358 → 802
    Integrin_alpha2; Integrin alpha

  4. XM_039082703.2 → XP_038938631.1  integrin alpha-9 isoform X4

    Conserved Domains (1) summary
    pfam08441
    Location:1 → 353
    Integrin_alpha2; Integrin alpha
Nucleotide Protein Strain
Heading Accession and Version

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