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Rab14 RAB14, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 68365, updated on 4-Jan-2025

Summary

Official Symbol
Rab14provided by MGI
Official Full Name
RAB14, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:1915615
See related
Ensembl:ENSMUSG00000026878 AllianceGenome:MGI:1915615
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610030G24Rik; 2810475J17Rik; A830021G03Rik; D030017L14Rik
Summary
Predicted to enable GTPase activity; guanyl ribonucleotide binding activity; and myosin V binding activity. Involved in Golgi to endosome transport; fibroblast growth factor receptor signaling pathway; and regulation of embryonic development. Predicted to be located in several cellular components, including Golgi stack; apical plasma membrane; and cytoplasmic vesicle. Predicted to be active in early endosome membrane; phagocytic vesicle; and synaptic vesicle membrane. Orthologous to human RAB14 (RAB14, member RAS oncogene family). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in adrenal adult (RPKM 151.4), stomach adult (RPKM 60.7) and 28 other tissues See more
Orthologs
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Genomic context

See Rab14 in Genome Data Viewer
Location:
2 B; 2 23.42 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (35070217..35091132, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (35180205..35201120, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene expressed sequence AI182371 Neighboring gene STARR-positive B cell enhancer ABC_E4440 Neighboring gene centriolin Neighboring gene STARR-positive B cell enhancer ABC_E2616 Neighboring gene STARR-positive B cell enhancer ABC_E5906 Neighboring gene STARR-positive B cell enhancer ABC_E7811 Neighboring gene predicted gene 13605 Neighboring gene predicted gene, 52553 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:35128407-35128590 Neighboring gene predicted gene, 39795 Neighboring gene gelsolin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3)  1 citation
  • Gene trapped (1) 

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP binding  
enables GDP binding  
enables GTP binding  
enables GTP binding  
enables GTPase activity  
enables GTPase activity  
enables GTPase activity  
enables GTPase activity  
enables myosin V binding  
enables myosin V binding  
enables protein binding PubMed 
Process Evidence Code Pubs
involved_in Golgi to endosome transport  
involved_in Golgi to endosome transport PubMed 
involved_in apical protein localization  
involved_in body fluid secretion  
involved_in defense response to bacterium  
involved_in early endosome to Golgi transport  
involved_in early endosome to Golgi transport  
involved_in endocytic recycling  
involved_in endocytic recycling  
involved_in endosomal vesicle fusion  
involved_in endosomal vesicle fusion  
involved_in fibroblast growth factor receptor signaling pathway PubMed 
involved_in intracellular protein transport  
involved_in phagolysosome assembly  
involved_in phagosome maturation  
involved_in protein transport  
involved_in regulation of embryonic development PubMed 
involved_in regulation of protein localization  
involved_in regulation of protein localization  
Items 1 - 20 of 27
Component Evidence Code Pubs
located_in Golgi membrane  
located_in Golgi stack  
located_in alveolar lamellar body  
located_in apical plasma membrane  
located_in cytoplasmic vesicle membrane  
located_in cytosol  
located_in cytosol  
is_active_in early endosome  
located_in early endosome  
located_in early endosome membrane  
is_active_in early endosome membrane  
is_active_in endomembrane system  
located_in intracellular membrane-bounded organelle  
located_in late endosome  
located_in lysosome  
located_in nuclear outer membrane-endoplasmic reticulum membrane network  
located_in perinuclear region of cytoplasm  
is_active_in phagocytic vesicle  
located_in phagocytic vesicle  
located_in phagocytic vesicle  
located_in plasma membrane  
located_in recycling endosome  
located_in recycling endosome  
located_in rough endoplasmic reticulum  
is_active_in synaptic vesicle membrane  
located_in trans-Golgi network  
located_in trans-Golgi network transport vesicle  
Items 1 - 20 of 27

General protein information

Preferred Names
ras-related protein Rab-14
NP_080973.1
XP_036018409.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026697.4NP_080973.1  ras-related protein Rab-14

    See identical proteins and their annotated locations for NP_080973.1

    Status: VALIDATED

    Source sequence(s)
    AL773523
    Consensus CDS
    CCDS15959.1
    UniProtKB/Swiss-Prot
    Q91V41
    UniProtKB/TrEMBL
    Q50HX2, Q50HX4
    Related
    ENSMUSP00000028238.9, ENSMUST00000028238.15
    Conserved Domains (1) summary
    cd04122
    Location:10175
    Rab14; Rab GTPase family 14 (Rab14)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    35070217..35091132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162516.1XP_036018409.1  ras-related protein Rab-14 isoform X1

    Conserved Domains (1) summary
    cl38936
    Location:10157
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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