Taf12 TATA-box binding protein associated factor 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Taf12provided by RGD
Official Full Name: TATA-box binding protein associated factor 12provided by RGD
Primary source: RGD:1592841
See related: Ensembl:ENSRNOG00000048288 AllianceGenome:RGD:1592841
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including DNA-binding transcription factor binding activity; TBP-class protein binding activity; and transcription coactivator activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly; histone H3 acetylation; and regulation of transcription, DNA-templated. Predicted to be located in nucleus. Predicted to be part of SAGA complex; transcription factor TFIID complex; and transcription factor TFTC complex. Orthologous to human TAF12 (TATA-box binding protein associated factor 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 57.5), Muscle (RPKM 56.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (149756826..149772886)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (144472816..144490299)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (150459701..150476521)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH139476 (e-PCR)
- UniSTS:221562

RH128062 (e-PCR)
- UniSTS:211370

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
contributes_to RNA polymerase II general transcription initiation factor activity	ISO Inferred from Sequence Orthology more info
enables TBP-class protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription initiation	ISO Inferred from Sequence Orthology more info
involved_in RNA polymerase II preinitiation complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA polymerase II preinitiation complex assembly	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in mRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription initiation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in transcription initiation at RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of SAGA complex	ISO Inferred from Sequence Orthology more info
part_of SLIK (SAGA-like) complex	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription factor TFIID complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIID complex	ISO Inferred from Sequence Orthology more info
part_of transcription factor TFTC complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcription initiation factor TFIID subunit 12

Names: TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001115036.1 → NP_001108508.1 transcription initiation factor TFIID subunit 12

See identical proteins and their annotated locations for NP_001108508.1

Status: PROVISIONAL

Source sequence(s)

CH473968

UniProtKB/TrEMBL

B0BMY3, M0R9S2

Related

ENSRNOP00000066252.1, ENSRNOT00000074251.2

Conserved Domains (1) summary

cd07981
Location:58 → 126

TAF12; TATA Binding Protein (TBP) Associated Factor 12

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

149756826..149772886

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006239067.5 → XP_006239129.1 transcription initiation factor TFIID subunit 12 isoform X1

UniProtKB/TrEMBL

A0A0G2JZ70, A0A8I6ABQ9

Related

ENSRNOP00000070933.1

Conserved Domains (1) summary

cd07981
Location:110 → 178

TAF12; TATA Binding Protein (TBP) Associated Factor 12
XM_006239068.5 → XP_006239130.1 transcription initiation factor TFIID subunit 12 isoform X2

See identical proteins and their annotated locations for XP_006239130.1

UniProtKB/TrEMBL

B0BMY3, M0R9S2

Conserved Domains (1) summary

cd07981
Location:58 → 126

TAF12; TATA Binding Protein (TBP) Associated Factor 12