Txlna taxilin alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Txlnaprovided by RGD
Official Full Name: taxilin alphaprovided by RGD
Primary source: RGD:1583435
See related: Ensembl:ENSRNOG00000048242 AllianceGenome:RGD:1583435
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable syntaxin binding activity. Predicted to act upstream of or within B cell activation. Predicted to be located in cytoplasm. Orthologous to human TXLNA (taxilin alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 199.5), Spleen (RPKM 154.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (147253694..147269410, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (141969337..141985054, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (147830514..147846193, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that alpha-taxilin plays multiple roles in the generation and maintenance of neurons through modulation of the NAC-mediated translational machinary and/or the syntaxin-mediated vesicle traffic in the soma.
Title: Developmental and spatial expression pattern of alpha-taxilin in the rat central nervous system.

Submit: New GeneRIF Correction

General gene information

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Markers

BE110414 (e-PCR)
- UniSTS:245255

BE119696 (e-PCR)
- UniSTS:249248

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables syntaxin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell activation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-taxilin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127633.1 → NP_001121105.1 alpha-taxilin

See identical proteins and their annotated locations for NP_001121105.1

Status: PROVISIONAL

Source sequence(s)

BC166486

UniProtKB/TrEMBL

B2GV14

Conserved Domains (2) summary

PHA03185
Location:507 → 556

PHA03185; UL14 tegument protein; Provisional

pfam09728
Location:171 → 478

Taxilin; Myosin-like coiled-coil protein