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Ppp2r3b protein phosphatase 2, regulatory subunit B'', beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 682033, updated on 13-Apr-2024

Summary

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Official Symbol
Ppp2r3bprovided by RGD
Official Full Name
protein phosphatase 2, regulatory subunit B'', betaprovided by RGD
Primary source
RGD:1588134
See related
Ensembl:ENSRNOG00000049270 AllianceGenome:RGD:1588134
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium-dependent protein serine/threonine phosphatase activity; chromatin binding activity; and protein phosphatase regulator activity. Predicted to be involved in protein dephosphorylation. Predicted to act upstream of or within negative regulation of G1/S transition of mitotic cell cycle and negative regulation of cell population proliferation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of protein phosphatase type 2A complex. Orthologous to human PPP2R3B (protein phosphatase 2 regulatory subunit B''beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 53.8), Thymus (RPKM 46.5) and 9 other tissues See more
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Genomic context

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Location:
14p22
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (103496..110739, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (88507..95750, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (1469748..1476353)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene transmembrane serine protease 9 like 1 Neighboring gene uncharacterized LOC134481808 Neighboring gene rCG57257-like Neighboring gene colony stimulating factor 2 receptor subunit alpha Neighboring gene karyopherin subunit alpha 1, pseudogene 2 Neighboring gene cytokine receptor-like factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus. Zhang CE, et al. Neurobiol Aging, 2008 Nov. PMID 17537547
  2. Functional interaction between a novel protein phosphatase 2A regulatory subunit, PR59, and the retinoblastoma-related p107 protein. Voorhoeve PM, et al. Oncogene, 1999 Jan 14. PMID 9927208
  3. Glutamate Counteracts Dopamine/PKA Signaling via Dephosphorylation of DARPP-32 Ser-97 and Alteration of Its Cytonuclear Distribution. Nishi A, et al. J Biol Chem, 2017 Jan 27. PMID 27998980, Free PMC Article
  4. Identification of potential nuclear reprogramming and differentiation factors by a novel selection method for cloning chromatin-binding proteins. Wang L, et al. Biochem Biophys Res Commun, 2004 Dec 3. PMID 15522233
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that homocysteine may be an upstream effector to induce AD-like tau hyperphosphorylation through inactivating PP2A.
    Title: Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase regulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001139492.2 → NP_001132964.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta

    See identical proteins and their annotated locations for NP_001132964.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A8I6A0V6, B1WBU2
    Related
    ENSRNOP00000065433.1, ENSRNOT00000071648.2
    Conserved Domains (1) summary
    pfam13499
    Location:328 → 422
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    103496..110739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092449.2 → XP_038948377.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X2

    UniProtKB/TrEMBL
    A0A8I6A0V6
    Conserved Domains (1) summary
    cl41751
    Location:110 → 424
    PPP2R3; serine/threonine protein phosphatase 2A regulatory subunit B"

  2. XM_039092446.2 → XP_038948374.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1

    UniProtKB/TrEMBL
    A0A8I6A0V6
    Conserved Domains (1) summary
    cl41751
    Location:132 → 488
    PPP2R3; serine/threonine protein phosphatase 2A regulatory subunit B"

  3. XM_063273623.1 → XP_063129693.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

  4. XM_063273624.1 → XP_063129694.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X4

RNA

  1. XR_010057417.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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