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Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 [ Mus musculus (house mouse) ]

Gene ID: 68202, updated on 5-Mar-2024

Summary

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Official Symbol
Ndufa5provided by MGI
Official Full Name
NADH:ubiquinone oxidoreductase subunit A5provided by MGI
Primary source
MGI:MGI:1915452
See related
Ensembl:ENSMUSG00000023089 AllianceGenome:MGI:1915452
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CI-13kD-B; 2900002J19Rik
Summary
Acts upstream of or within respiratory electron transport chain. Located in mitochondrion. Part of respiratory chain complex I. Is expressed in several structures, including alimentary system; cranium; liver; nervous system; and urinary system. Orthologous to human NDUFA5 (NADH:ubiquinone oxidoreductase subunit A5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 29.1), cerebellum adult (RPKM 24.8) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 A3.1; 6 11.28 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (24518661..24527689, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (24518662..24527690, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15351 Neighboring gene zinc finger and SCAN domain containing 5B pseudogene Neighboring gene IQ motif and ubiquitin domain containing Neighboring gene STARR-positive B cell enhancer mm9_chr6:24477506-24477807 Neighboring gene STARR-positive B cell enhancer ABC_E2778 Neighboring gene ankyrin repeat and SOCS box-containing 15 Neighboring gene leiomodin 2 (cardiac)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hepatocyte miR-33a mediates mitochondrial dysfunction and hepatosteatosis by suppressing NDUFA5. Nie H, et al. J Cell Mol Med, 2018 Dec. PMID 30324697, Free PMC Article
  2. Identification of NADH dehydrogenase 1 alpha subcomplex 5 capable to transform murine fibroblasts and overexpressed in human cervical carcinoma cell lines. Shimada T, et al. Biochem Biophys Res Commun, 2006 Jan 20. PMID 16329995
  3. Partial complex I deficiency due to the CNS conditional ablation of Ndufa5 results in a mild chronic encephalopathy but no increase in oxidative damage. Peralta S, et al. Hum Mol Genet, 2014 Mar 15. PMID 24154540, Free PMC Article
  4. IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins. Dai N, et al. Cell Metab, 2015 Apr 7. PMID 25863250, Free PMC Article
  5. Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function. Yavari A, et al. Cell Metab, 2016 May 10. PMID 27133129, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Through bioinformatics prediction, we found miR-33a directly targeted on the 3'-UTR of NDUFA5. Dual-luciferase reporter analysis further confirmed the direct suppression of miR-33a on NDUFA5 expression
    Title: Hepatocyte miR-33a mediates mitochondrial dysfunction and hepatosteatosis by suppressing NDUFA5.
  2. At the age of 11 months, mice with a central nervous system knockout of Ndufa5 (Ndufa5 CNS-KO) showed lethargy and loss of motor skills. In these mice cortices, the levels of NDUFA5 protein were reduced to 25% of controls. Fully assembled complex I (CI) levels were also greatly reduced in cortex and CI activity in homogenates was reduced to 60% of controls.
    Title: Partial complex I deficiency due to the CNS conditional ablation of Ndufa5 results in a mild chronic encephalopathy but no increase in oxidative damage.
  3. The real-time RT-PCR analysis revealed that the expressions of the NDUFA5 mRNA, but not the ZNF9 mRNA level, were significantly up-regulated in all the tested cell lines derived from HPV-positive cervical cancer, HeLa, SW576, and CaSKi.
    Title: Identification of NADH dehydrogenase 1 alpha subcomplex 5 capable to transform murine fibroblasts and overexpressed in human cervical carcinoma cell lines.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in aerobic respiration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in proton motive force-driven mitochondrial ATP synthesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in respiratory electron transport chain IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within respiratory electron transport chain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
located_in respirasome IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex I IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
Names
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
NADH-ubiquinone oxidoreductase 13 kDa-B subunit
complex I subunit B13
complex I-13kD-B
NP_001297997.1
NP_080890.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311068.2 → NP_001297997.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform 2

    See identical proteins and their annotated locations for NP_001297997.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AC153635, BY247454, BY253904, W66892
    Consensus CDS
    CCDS80494.1
    UniProtKB/TrEMBL
    D3YTQ8
    Related
    ENSMUSP00000112971.2, ENSMUST00000118558.5

  2. NM_026614.3 → NP_080890.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform 1

    See identical proteins and their annotated locations for NP_080890.1

    Status: VALIDATED

    Source sequence(s)
    AK019301, BY253904, W66892
    Consensus CDS
    CCDS19942.1
    UniProtKB/Swiss-Prot
    Q9CPP6, Q9CY90, Q9D2P2, Q9D703, Q9D739
    UniProtKB/TrEMBL
    Q9CX78
    Related
    ENSMUSP00000023851.6, ENSMUST00000023851.9
    Conserved Domains (1) summary
    pfam04716
    Location:13 → 78
    ETC_C1_NDUFA5; ETC complex I subunit conserved region

RNA

  1. NR_154219.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153635, AC155284
    Related
    ENSMUST00000141274.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    24518661..24527689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CPP6.3 GenPept UniProtKB/Swiss-Prot:Q9CPP6

Gene LinkOut

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