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SULT2B1 sulfotransferase family 2B member 1 [ Homo sapiens (human) ]

Gene ID: 6820, updated on 5-Mar-2024

Summary

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Official Symbol
SULT2B1provided by HGNC
Official Full Name
sulfotransferase family 2B member 1provided by HGNC
Primary source
HGNC:HGNC:11459
See related
Ensembl:ENSG00000088002 MIM:604125; AllianceGenome:HGNC:11459
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSST2; ARCI14
Summary
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Biased expression in esophagus (RPKM 55.8), skin (RPKM 46.5) and 4 other tissues See more
Orthologs
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Genomic context

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Location:
19q13.33
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (48552172..48599427)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (51546347..51593563)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49055429..49102684)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372430 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48972285-48973278 Neighboring gene MPRA-validated peak3539 silencer Neighboring gene cytohesin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48993225-48993796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10882 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10884 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:48996420-48996611 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10886 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:48997173-48997673 Neighboring gene lemur tyrosine kinase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10887 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10888 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:49017633-49017779 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49046825-49047364 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49048751-49049694 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49054849-49055373 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49057162-49058100 Neighboring gene Sharpr-MPRA regulatory regions 10218 and 12364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14898 Neighboring gene family with sequence similarity 83 member E Neighboring gene ReSE screen-validated silencer GRCh37_chr19:49117268-49117444 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49117749-49118580 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49118581-49119412 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49119413-49120243 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:49121076-49121906 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14902 Neighboring gene sperm acrosome associated 4 Neighboring gene ribosomal protein L18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SULT2B1b inhibits reverse cholesterol transport and promotes cholesterol accumulation and inflammation in lymphocytes from AMI patients with low LDL-C levels. Zhang Y, et al. Clin Sci (Lond), 2020 Jan 31. PMID 31957803
  2. Distinct expression patterns of SULT2B1b in human prostate epithelium. Yang J, et al. Prostate, 2019 Aug. PMID 31212370, Free PMC Article
  3. Cholesterol Sulfotransferase SULT2B1b Modulates Sensitivity to Death Receptor Ligand TNFα in Castration-Resistant Prostate Cancer. Vickman RE, et al. Mol Cancer Res, 2019 Jun. PMID 30824526, Free PMC Article
  4. Association study of genetic variants in estrogen metabolic pathway genes and colorectal cancer risk and survival. Li S, et al. Arch Toxicol, 2018 Jun. PMID 29766219
  5. On the role of genetic polymorphisms in the sulfation of cholesterol by human cytosolic sulphotransferase SULT2B1b. Alherz FA, et al. J Biochem, 2018 Sep 1. PMID 29701841, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sulfotransferase SULT2B1 facilitates colon cancer metastasis by promoting SCD1-mediated lipid metabolism.
    Title: Sulfotransferase SULT2B1 facilitates colon cancer metastasis by promoting SCD1-mediated lipid metabolism.
  2. Macrophage Sult2b1 promotes pathological neovascularization in age-related macular degeneration.
    Title: Macrophage Sult2b1 promotes pathological neovascularization in age-related macular degeneration.
  3. The promoter hypermethylation of SULT2B1 accelerates esophagus tumorigenesis via downregulated PER1.
    Title: The promoter hypermethylation of SULT2B1 accelerates esophagus tumorigenesis via downregulated PER1.
  4. undetectable in nearly all castration-resistant prostate cancer metastases (73 visceral, 82 bone) from 50 autopsy cases
    Title: Inhibitory Interplay of SULT2B1b Sulfotransferase with AKR1C3 Aldo-keto Reductase in Prostate Cancer.
  5. The abundant SULT2B1 expression in normal gastric epithelium might maintain epithelial function via the PI3K/AKT signaling pathway.
    Title: Hydroxysteroid sulfotransferase 2B1 affects gastric epithelial function and carcinogenesis induced by a carcinogenic agent.
  6. SULT2B1b expression enhances resistance to TNF and may promote prostate cancer.
    Title: Cholesterol Sulfotransferase SULT2B1b Modulates Sensitivity to Death Receptor Ligand TNFα in Castration-Resistant Prostate Cancer.
  7. Data suggest therapeutic approaches to decrease sulphotransferase 2B1b (SULT2B1b) expression might be potentially beneficial for coronary artery disease (CAD) prevention by decreasing intracellular cholesterol.
    Title: SULT2B1b inhibits reverse cholesterol transport and promotes cholesterol accumulation and inflammation in lymphocytes from AMI patients with low LDL-C levels.
  8. SULT2B1b inversely correlates with prostate cancer status, with the highest level in the normal epithelium and lowest in the advanced metastatic prostate cancer. Furthermore, SULT2B1b is mostly located within the luminal layer of the prostate epithelium, suggesting that it may be implicated in luminal differentiation.
    Title: Distinct expression patterns of SULT2B1b in human prostate epithelium.
  9. Sulfotransferase 2B1b (SULT2B1b) interference attenuated the invasion abilities of human hepatocarcinoma BEL-7402cells. SULT2B1b interference inhibited the activation of the beta-catenin/MMP-7 pathway.
    Title: SULT2B1b promotes epithelial-mesenchymal transition through activation of the β-catenin/MMP7 pathway in hepatocytes.
  10. SULT2B1 expression was significantly higher in colorectal tumor tissues than in normal tissues.
    Title: Association study of genetic variants in estrogen metabolic pathway genes and colorectal cancer risk and survival.
Submit: New GeneRIF Correction See all GeneRIFs (38)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cholesterol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cholesterol sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small molecule binding EXP
Inferred from Experiment
more info
 PubMed 
enables steroid hormone binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables steroid sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cholesterol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of epidermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in steroid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sulfation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sulfotransferase 2B1
Names
ST2B1
alcohol sulfotransferase
hydroxysteroid sulfotransferase 2
hydroxysteroid sulfotransferase SULT2B1a
sulfotransferase family, cytosolic, 2B, member 1
NP_004596.2
NP_814444.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029063.1 RefSeqGene

    Range
    5001..52252
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004605.2 → NP_004596.2  sulfotransferase 2B1 isoform a

    See identical proteins and their annotated locations for NP_004596.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as SULT2B1a, differs in the 5' UTR and in the coding region when compared to variant 2. The resulting protein (isoform a) has a shorter and distinct N-terminus compared to isoform b.
    Source sequence(s)
    U92314
    Consensus CDS
    CCDS12724.1
    UniProtKB/Swiss-Prot
    O00204
    Related
    ENSP00000312880.3, ENST00000323090.4
    Conserved Domains (1) summary
    pfam00685
    Location:45 → 290
    Sulfotransfer_1; Sulfotransferase domain

  2. NM_177973.2 → NP_814444.1  sulfotransferase 2B1 isoform b

    See identical proteins and their annotated locations for NP_814444.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is also known as SULT2B1b. It is the predominant transcript and it encodes the longer protein (isoform b).
    Source sequence(s)
    AC008403
    Consensus CDS
    CCDS12723.1
    UniProtKB/Swiss-Prot
    O00204, O00205, O75814
    Related
    ENSP00000201586.2, ENST00000201586.7
    Conserved Domains (1) summary
    pfam00685
    Location:60 → 305
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    48552172..48599427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    51546347..51593563
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O00204.2 GenPept UniProtKB/Swiss-Prot:O00204

Gene LinkOut

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