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Ndufb2 NADH:ubiquinone oxidoreductase subunit B2 [ Mus musculus (house mouse) ]

Gene ID: 68198, updated on 5-Mar-2024

Summary

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Official Symbol
Ndufb2provided by MGI
Official Full Name
NADH:ubiquinone oxidoreductase subunit B2provided by MGI
Primary source
MGI:MGI:1915448
See related
Ensembl:ENSMUSG00000002416 AllianceGenome:MGI:1915448
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
8kDa; AGGG; CI-AGGG; 1810011O01Rik
Summary
Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Is expressed in several structures, including axial skeleton; cranium; ear; limb; and musculature. Orthologous to human NDUFB2 (NADH:ubiquinone oxidoreductase subunit B2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 286.4), duodenum adult (RPKM 227.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 B1; 6 18.42 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (39569499..39576777)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (39592565..39599843)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene DENN domain containing 2A Neighboring gene RIKEN cDNA 8030453O22 gene Neighboring gene VISTA enhancer mm1321 Neighboring gene aarF domain containing kinase 2 Neighboring gene Braf transforming gene Neighboring gene predicted gene, 34389 Neighboring gene ferritin heavy chain, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins. Dai N, et al. Cell Metab, 2015 Apr 7. PMID 25863250, Free PMC Article
  2. Histone deacetylase 3 controls lung alveolar macrophage development and homeostasis. Yao Y, et al. Nat Commun, 2020 Jul 30. PMID 32732898, Free PMC Article
  3. Region-specific expression of mitochondrial complex I genes during murine brain development. Wirtz S, et al. PLoS One, 2011 Apr 27. PMID 21556144, Free PMC Article
  4. Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes. Signes A, et al. Essays Biochem, 2018 Jul 20. PMID 30030361, Free PMC Article
  5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in aerobic respiration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitochondrial respiratory chain complex I assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in proton motive force-driven mitochondrial ATP synthesis NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in respirasome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial
Names
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2
NADH-ubiquinone oxidoreductase AGGG subunit
complex I-AGGG
NP_001345726.1
NP_080888.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358797.1 → NP_001345726.1  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    AC122345, AK028334
    Consensus CDS
    CCDS20025.1
    UniProtKB/Swiss-Prot
    Q9CPU2
    Related
    ENSMUSP00000118918.2, ENSMUST00000135671.8
    Conserved Domains (1) summary
    pfam14813
    Location:37 → 104
    NADH_B2; NADH dehydrogenase 1 beta subcomplex subunit 2

  2. NM_026612.4 → NP_080888.1  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_080888.1

    Status: VALIDATED

    Source sequence(s)
    AC122345, AK019008, CF533247
    Consensus CDS
    CCDS20025.1
    UniProtKB/Swiss-Prot
    Q9CPU2
    Related
    ENSMUSP00000114095.2, ENSMUST00000119379.2
    Conserved Domains (1) summary
    pfam14813
    Location:37 → 104
    NADH_B2; NADH dehydrogenase 1 beta subcomplex subunit 2

RNA

  1. NR_152450.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122345, AI391300, CF533247

  2. NR_152451.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122345

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    39569499..39576777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CPU2.1 GenPept UniProtKB/Swiss-Prot:Q9CPU2

Gene LinkOut

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