U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gstz1 glutathione S-transferase zeta 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 681913, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Gstz1provided by RGD
Official Full Name
glutathione S-transferase zeta 1provided by RGD
Primary source
RGD:1589363
See related
Ensembl:ENSRNOG00000047708 AllianceGenome:RGD:1589363
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable glutathione transferase activity; maleylacetoacetate isomerase activity; and protein homodimerization activity. Predicted to be involved in L-phenylalanine catabolic process and glutathione metabolic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Orthologous to human GSTZ1 (glutathione S-transferase zeta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 1483.3), Kidney (RPKM 463.6) and 3 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Gstz1 in Genome Data Viewer
Location:
6q31
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (112525576..112536228)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (106794594..106805284)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (111176798..111187246)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene neuroglobin Neighboring gene protein-O-mannosyltransferase 2 Neighboring gene uncharacterized LOC134479237 Neighboring gene transmembrane p24 trafficking protein family member 8 Neighboring gene sterile alpha motif domain containing 15

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Regulation of dichloroacetate biotransformation in rat liver and extrahepatic tissues by GSTZ1 expression and chloride concentration. Jahn SC, et al. Biochem Pharmacol, 2018 Jun. PMID 29626439, Free PMC Article
  2. Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1. Li W, et al. J Pharmacol Exp Ther, 2011 Jan. PMID 20884751, Free PMC Article
  3. Crystal structure of maleylacetoacetate isomerase/glutathione transferase zeta reveals the molecular basis for its remarkable catalytic promiscuity. Polekhina G, et al. Biochemistry, 2001 Feb 13. PMID 11327815
  4. Discovery of a functional polymorphism in human glutathione transferase zeta by expressed sequence tag database analysis. Blackburn AC, et al. Pharmacogenetics, 2000 Feb. PMID 10739172
  5. Glutathione transferase zeta catalyses the oxygenation of the carcinogen dichloroacetic acid to glyoxylic acid. Tong Z, et al. Biochem J, 1998 Apr 15. PMID 9531472, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study evaluated the metabolism of dichloroacetic acid in liver, hear, brain, and kidney via GSTZ1.
    Title: Regulation of dichloroacetate biotransformation in rat liver and extrahepatic tissues by GSTZ1 expression and chloride concentration.
  2. The mitochondrion is a second site of dichloroacetate biotransformation in a reaction catalyzed by GSTZ1, an enzyme colocalized in the mitochondrial matrix and cytosol.
    Title: Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables maleylacetoacetate isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables maleylacetoacetate isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables maleylacetoacetate isomerase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in L-phenylalanine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-phenylalanine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in tyrosine catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
maleylacetoacetate isomerase
Names
GSTZ1-1
MAAI
glutathione S-transferase alpha 3
glutathione transferase zeta 1
NP_001102915.1
XP_006240461.1
XP_038968853.1
XP_063118542.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109445.1 → NP_001102915.1  maleylacetoacetate isomerase

    See identical proteins and their annotated locations for NP_001102915.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473982
    UniProtKB/Swiss-Prot
    B0BNI1, P57113
    Related
    ENSRNOP00000065390.2, ENSRNOT00000072215.3
    Conserved Domains (3) summary
    cd03191
    Location:93 → 207
    GST_C_Zeta; C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases
    cd03042
    Location:6 → 80
    GST_N_Zeta; GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
    TIGR01262
    Location:7 → 211
    maiA; maleylacetoacetate isomerase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    112525576..112536228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112925.2 → XP_038968853.1  maleylacetoacetate isomerase isoform X2

    Conserved Domains (1) summary
    TIGR01262
    Location:58 → 191
    maiA; maleylacetoacetate isomerase

  2. XM_006240399.5 → XP_006240461.1  maleylacetoacetate isomerase isoform X1

    See identical proteins and their annotated locations for XP_006240461.1

    UniProtKB/TrEMBL
    A0A0G2K6H2, A6JE83
    Related
    ENSRNOP00000073813.1
    Conserved Domains (1) summary
    TIGR01262
    Location:6 → 210
    maiA; maleylacetoacetate isomerase

  3. XM_063262472.1 → XP_063118542.1  maleylacetoacetate isomerase isoform X3

    UniProtKB/TrEMBL
    A6JE85
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P57113.2 GenPept UniProtKB/Swiss-Prot:P57113

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous