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Aup1 AUP1, lipid droplet regulating VLDL assembly factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 680423, updated on 2-May-2024

Summary

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Official Symbol
Aup1provided by RGD
Official Full Name
AUP1, lipid droplet regulating VLDL assembly factorprovided by RGD
Primary source
RGD:1591777
See related
Ensembl:ENSRNOG00000007842 AllianceGenome:RGD:1591777
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable enzyme binding activity; ubiquitin binding activity; and ubiquitin-protein transferase activator activity. Predicted to be involved in several processes, including ERAD pathway; lipid droplet formation; and lipophagy. Predicted to be located in autophagosome; endoplasmic reticulum; and lipid droplet. Predicted to be part of Hrd1p ubiquitin ligase ERAD-L complex. Predicted to be active in membrane. Predicted to be integral component of endoplasmic reticulum membrane. Orthologous to human AUP1 (AUP1 lipid droplet regulating VLDL assembly factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 260.8), Kidney (RPKM 258.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q34
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (117118035..117121063)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (115560274..115563346)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (113887030..113890103)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene docking protein 1 Neighboring gene lysyl oxidase-like 3 Neighboring gene HtrA serine peptidase 2 Neighboring gene DEAQ box RNA-dependent ATPase 1 Neighboring gene T-cell leukemia homeobox 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation. Ma Q, et al. Cell Signal, 2008 Jun. PMID 18299187
  2. Identification of ERAD components essential for dislocation of the null Hong Kong variant of α-1-antitrypsin (NHK). Zhong Y, et al. Biochem Biophys Res Commun, 2015 Mar 6. PMID 25660456
  3. Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. Kang D, et al. J Proteome Res, 2008 Aug. PMID 18570454
  4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
  5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin conjugating enzyme binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in ERAD pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid droplet formation IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid droplet formation ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid droplet formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid droplet organization ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid droplet organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in lipophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to lipid droplet IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to lipid droplet ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to lipid droplet ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde protein transport, ER to cytosol IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde protein transport, ER to cytosol ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in autophagosome IEA
Inferred from Electronic Annotation
more info
  
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in lipid droplet ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
lipid droplet-regulating VLDL assembly factor AUP1
Names
ancient ubiquitous protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079899.1 → NP_001073368.1  lipid droplet-regulating VLDL assembly factor AUP1

    See identical proteins and their annotated locations for NP_001073368.1

    Status: PROVISIONAL

    Source sequence(s)
    BC127544
    UniProtKB/Swiss-Prot
    A1L134
    UniProtKB/TrEMBL
    A0A8L2Q4W6
    Related
    ENSRNOP00000010602.6, ENSRNOT00000010602.8
    Conserved Domains (2) summary
    cd14420
    Location:300 → 340
    CUE_AUP1; CUE domain found in ancient ubiquitous protein 1 (AUP1) and similar proteins
    cl17185
    Location:66 → 264
    LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    117118035..117121063
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286675.1 → XP_063142745.1  lipid droplet-regulating VLDL assembly factor AUP1 isoform X1

  2. XM_008763029.3 → XP_008761251.1  lipid droplet-regulating VLDL assembly factor AUP1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5YCA8
    Conserved Domains (2) summary
    cd14420
    Location:300 → 340
    CUE_AUP1; CUE domain found in ancient ubiquitous protein 1 (AUP1) and similar proteins
    cl17185
    Location:66 → 264
    LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1L134.1 GenPept UniProtKB/Swiss-Prot:A1L134

Gene LinkOut

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