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Aup1 AUP1, lipid droplet regulating VLDL assembly factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 680423, updated on 4-Jan-2025

Summary

Official Symbol
Aup1provided by RGD
Official Full Name
AUP1, lipid droplet regulating VLDL assembly factorprovided by RGD
Primary source
RGD:1591777
See related
EnsemblRapid:ENSRNOG00000007842 AllianceGenome:RGD:1591777
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including lipid droplet formation; lipophagy; and protein localization to lipid droplet. Predicted to be located in autophagosome; endoplasmic reticulum; and lipid droplet. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human AUP1 (AUP1 lipid droplet regulating VLDL assembly factor). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Liver (RPKM 260.8), Kidney (RPKM 258.6) and 9 other tissues See more
Orthologs
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Genomic context

See Aup1 in Genome Data Viewer
Location:
4q34
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (117118035..117121063)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (115560274..115563346)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (113887030..113890103)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene docking protein 1 Neighboring gene lysyl oxidase-like 3 Neighboring gene HtrA serine peptidase 2 Neighboring gene DEAQ box RNA-dependent ATPase 1 Neighboring gene T-cell leukemia homeobox 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin binding  
enables ubiquitin conjugating enzyme binding  
enables ubiquitin conjugating enzyme binding  
enables ubiquitin conjugating enzyme binding  
enables ubiquitin protein ligase binding  
enables ubiquitin protein ligase binding  
enables ubiquitin protein ligase binding  
Process Evidence Code Pubs
involved_in ERAD pathway  
involved_in ERAD pathway  
involved_in ERAD pathway  
involved_in ERAD pathway  
involved_in lipid droplet formation  
involved_in lipid droplet formation  
involved_in lipid droplet formation  
involved_in lipid droplet organization  
involved_in lipid droplet organization  
involved_in lipophagy  
involved_in lipophagy  
involved_in protein localization to lipid droplet  
involved_in protein localization to lipid droplet  
involved_in protein localization to lipid droplet  
involved_in response to virus  
involved_in response to virus  
involved_in retrograde protein transport, ER to cytosol  
involved_in retrograde protein transport, ER to cytosol  
Component Evidence Code Pubs
located_in autophagosome  
located_in autophagosome  
located_in endoplasmic reticulum  
is_active_in endoplasmic reticulum membrane  
located_in endoplasmic reticulum membrane  
located_in endoplasmic reticulum membrane  
located_in endoplasmic reticulum membrane  
located_in lipid droplet  
located_in lipid droplet  
located_in lipid droplet  

General protein information

Preferred Names
lipid droplet-regulating VLDL assembly factor AUP1
Names
ancient ubiquitous protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079899.1NP_001073368.1  lipid droplet-regulating VLDL assembly factor AUP1

    See identical proteins and their annotated locations for NP_001073368.1

    Status: PROVISIONAL

    Source sequence(s)
    BC127544
    UniProtKB/Swiss-Prot
    A1L134
    UniProtKB/TrEMBL
    A0A8L2Q4W6
    Related
    ENSRNOP00000077286.2, ENSRNOT00000104950.2
    Conserved Domains (2) summary
    cd14420
    Location:300340
    CUE_AUP1; CUE domain found in ancient ubiquitous protein 1 (AUP1) and similar proteins
    cl17185
    Location:66264
    LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    117118035..117121063
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286675.1XP_063142745.1  lipid droplet-regulating VLDL assembly factor AUP1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5YCA8
    Related
    ENSRNOP00000010602.7, ENSRNOT00000010602.9
  2. XM_008763029.3XP_008761251.1  lipid droplet-regulating VLDL assembly factor AUP1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5YCA8
    Conserved Domains (2) summary
    cd14420
    Location:300340
    CUE_AUP1; CUE domain found in ancient ubiquitous protein 1 (AUP1) and similar proteins
    cl17185
    Location:66264
    LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
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