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Bambi BMP and activin membrane-bound inhibitor [ Mus musculus (house mouse) ]

Gene ID: 68010, updated on 5-Mar-2024

Summary

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Official Symbol
Bambiprovided by MGI
Official Full Name
BMP and activin membrane-bound inhibitorprovided by MGI
Primary source
MGI:MGI:1915260
See related
Ensembl:ENSMUSG00000024232 AllianceGenome:MGI:1915260
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610003H06Rik
Summary
Predicted to enable frizzled binding activity. Predicted to be involved in several processes, including positive regulation of epithelial to mesenchymal transition; regulation of signal transduction; and transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within negative regulation of BMP signaling pathway. Predicted to be located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human BAMBI (BMP and activin membrane bound inhibitor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 11.7), lung adult (RPKM 6.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 A1; 18 2.3 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (3507011..3516404)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (3507011..3516404)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene cullin 2 Neighboring gene STARR-seq mESC enhancer starr_43658 Neighboring gene profilin 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_43660 Neighboring gene STARR-positive B cell enhancer ABC_E10980 Neighboring gene STARR-seq mESC enhancer starr_43661 Neighboring gene STARR-seq mESC enhancer starr_43662 Neighboring gene STARR-seq mESC enhancer starr_43663 Neighboring gene STARR-seq mESC enhancer starr_43664 Neighboring gene STARR-seq mESC enhancer starr_43666 Neighboring gene STARR-seq mESC enhancer starr_43667 Neighboring gene predicted gene, 54028 Neighboring gene ribosomal protein L7A, pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Therapeutic Effects of Anti-Bone Morphogenetic Protein and Activin Membrane-Bound Inhibitor Treatment in Psoriasis and Arthritis. Alvarez P, et al. Arthritis Rheumatol, 2020 Sep. PMID 32249544
  2. Leptin promotes epithelial-mesenchymal transition in benign prostatic hyperplasia through downregulation of BAMBI. Zhang B, et al. Exp Cell Res, 2020 Feb 1. PMID 31805276
  3. Defective fibrin deposition and thrombus stability in Bambi(-/-) mice are mediated by elevated anticoagulant function. Crawley JTB, et al. J Thromb Haemost, 2019 Nov. PMID 31351019, Free PMC Article
  4. BAMBI shuttling between cytosol and membrane is required for skeletal muscle development and regeneration. Yao X, et al. Biochem Biophys Res Commun, 2019 Jan 29. PMID 30580997
  5. BMP and Activin Membrane Bound Inhibitor Regulates the Extracellular Matrix in the Trabecular Meshwork. Hernandez H, et al. Invest Ophthalmol Vis Sci, 2018 Apr 1. PMID 29801150, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Epitranscriptional regulation of TGF-beta pseudoreceptor BAMBI by m6A/YTHDF2 drives extrinsic radioresistance.
    Title: Epitranscriptional regulation of TGF-β pseudoreceptor BAMBI by m6A/YTHDF2 drives extrinsic radioresistance.
  2. Therapeutic Effects of Anti-Bone Morphogenetic Protein and Activin Membrane-Bound Inhibitor Treatment in Psoriasis and Arthritis.
    Title: Therapeutic Effects of Anti-Bone Morphogenetic Protein and Activin Membrane-Bound Inhibitor Treatment in Psoriasis and Arthritis.
  3. Leptin promotes epithelial-mesenchymal transition in benign prostatic hyperplasia through downregulation of BAMBI.
    Title: Leptin promotes epithelial-mesenchymal transition in benign prostatic hyperplasia through downregulation of BAMBI.
  4. Defective fibrin deposition and thrombus stability in Bambi(-/-) mice are mediated by elevated anticoagulant function.
    Title: Defective fibrin deposition and thrombus stability in Bambi(-/-) mice are mediated by elevated anticoagulant function.
  5. Comparing with the cytosolic trapping in resting muscle, BAMBI protein is enriched on cellular membrane during the muscle growth and regeneration, suggesting that BAMBI-mediated a significant signaling pathway may be an essential part of muscle growth and regeneration.
    Title: BAMBI shuttling between cytosol and membrane is required for skeletal muscle development and regeneration.
  6. BAMBI is required for normal C2C12 differentiation, and that its role in myogenesis is mediated by the Wnt/beta-catenin pathway.
    Title: BAMBI Promotes C2C12 Myogenic Differentiation by Enhancing Wnt/β-Catenin Signaling.
  7. BAMBI modulates the effects of diabetes on glomerular permselectivity in association with altered ERK1/2 and Smad1/5 signaling.
    Title: BAMBI elimination enhances alternative TGF-β signaling and glomerular dysfunction in diabetic mice.
  8. these results provide strong evidence for an important role of endothelium rather than platelet BAMBI as a positive regulator of both thrombus formation and stability.
    Title: Vessel wall BAMBI contributes to hemostasis and thrombus stability.
  9. we provide in vitro and in vivo evidence that BAMBI contributes to endothelial and vascular homeostasis
    Title: BAMBI regulates angiogenesis and endothelial homeostasis through modulation of alternative TGFβ signaling.
  10. suggest that BAMBI is involved in negative feedback loops that restrain the TGF-beta remodeling signals to protect the pressure-overloaded myocardium from uncontrolled extracellular matrix deposition in humans and mice
    Title: BAMBI (BMP and activin membrane-bound inhibitor) protects the murine heart from pressure-overload biomechanical stress by restraining TGF-β signaling.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables frizzled binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway ISA
Inferred from Sequence Alignment
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
BMP and activin membrane-bound inhibitor homolog
Names
BMP and activin membrane-bound inhibitor, homolog
putative transmembrane protein NMA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026505.2 → NP_080781.1  BMP and activin membrane-bound inhibitor homolog precursor

    See identical proteins and their annotated locations for NP_080781.1

    Status: PROVISIONAL

    Source sequence(s)
    AC140240
    Consensus CDS
    CCDS29034.1
    UniProtKB/Swiss-Prot
    Q3TP85, Q91XS6, Q9D0L6
    UniProtKB/TrEMBL
    A0A2C9NTD7
    Related
    ENSMUSP00000025075.2, ENSMUST00000025075.3
    Conserved Domains (1) summary
    pfam06211
    Location:4 → 111
    BAMBI; BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    3507011..3516404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250585.1 → XP_030106445.1  BMP and activin membrane-bound inhibitor homolog isoform X1

    UniProtKB/Swiss-Prot
    Q3TP85, Q91XS6, Q9D0L6
    UniProtKB/TrEMBL
    A0A2C9NTD7
    Conserved Domains (1) summary
    pfam06211
    Location:4 → 111
    BAMBI; BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D0L6.1 GenPept UniProtKB/Swiss-Prot:Q9D0L6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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