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Gpr183 G protein-coupled receptor 183 [ Rattus norvegicus (Norway rat) ]

Gene ID: 679975, updated on 5-Mar-2024

Summary

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Official Symbol
Gpr183provided by RGD
Official Full Name
G protein-coupled receptor 183provided by RGD
Primary source
RGD:1598095
See related
Ensembl:ENSRNOG00000025094 AllianceGenome:RGD:1598095
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ebi2
Summary
Predicted to enable G protein-coupled receptor activity and oxysterol binding activity. Predicted to be involved in several processes, including dendritic cell homeostasis; leukocyte chemotaxis; and leukocyte differentiation. Predicted to be located in plasma membrane. Orthologous to human GPR183 (G protein-coupled receptor 183). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 29.5), Thymus (RPKM 19.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
15q25
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (105445129..105457192, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (99037764..99050550, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (108364701..108376221, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene dedicator of cytokinesis 9 Neighboring gene uncharacterized LOC134482163 Neighboring gene UBA domain containing 2 Neighboring gene G protein-coupled receptor 18 Neighboring gene uncharacterized LOC108352982 Neighboring gene translocase of inner mitochondrial membrane 8A2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. EBI2 regulates intracellular signaling and migration in human astrocyte. Rutkowska A, et al. Glia, 2015 Feb. PMID 25297897
  2. Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor. Gessier F, et al. J Med Chem, 2014 Apr 24. PMID 24678947
  3. Identification of structural motifs critical for epstein-barr virus-induced molecule 2 function and homology modeling of the ligand docking site. Zhang L, et al. Mol Pharmacol, 2012 Dec. PMID 22930711
  4. Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183). Benned-Jensen T, et al. J Biol Chem, 2012 Oct 12. PMID 22875855, Free PMC Article
  5. Oxysterols direct B-cell migration through EBI2. Liu C, et al. Nature, 2011 Jul 27. PMID 21796211

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxysterol binding ISO
Inferred from Sequence Orthology
more info
  
enables oxysterol binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in B cell activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in T cell chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in T follicular helper cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in T follicular helper cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in adaptive immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in adaptive immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in dendritic cell chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in dendritic cell chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in dendritic cell homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in dendritic cell homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in humoral immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within leukocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in leukocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in leukocyte chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mature B cell differentiation involved in immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in osteoclast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of B cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of astrocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of astrocyte chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
G-protein coupled receptor 183
Names
EBV-induced G-protein coupled receptor 2
Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor)
epstein-Barr virus-induced G-protein coupled receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109386.1 → NP_001102856.1  G-protein coupled receptor 183

    See identical proteins and their annotated locations for NP_001102856.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473951
    UniProtKB/Swiss-Prot
    D4A7K7
    Related
    ENSRNOP00000097517.1, ENSRNOT00000098097.1
    Conserved Domains (1) summary
    cd15159
    Location:28 → 315
    7tmA_EBI2; Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    105445129..105457192 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093645.2 → XP_038949573.1  G-protein coupled receptor 183 isoform X1

    UniProtKB/Swiss-Prot
    D4A7K7
    Related
    ENSRNOP00000035137.3
    Conserved Domains (1) summary
    cd15159
    Location:28 → 315
    7tmA_EBI2; Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D4A7K7.1 GenPept UniProtKB/Swiss-Prot:D4A7K7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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