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U2surp U2 snRNP-associated SURP domain containing [ Mus musculus (house mouse) ]

Gene ID: 67958, updated on 11-Apr-2024

Summary

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Official Symbol
U2surpprovided by MGI
Official Full Name
U2 snRNP-associated SURP domain containingprovided by MGI
Primary source
MGI:MGI:1915208
See related
Ensembl:ENSMUSG00000032407 AllianceGenome:MGI:1915208
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sr140; 2610101N10Rik
Summary
Predicted to enable RNA binding activity. Predicted to be involved in RNA processing. Part of U2 snRNP. Is expressed in central nervous system and sensory organ. Orthologous to human U2SURP (U2 snRNP associated SURP domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 12.0), CNS E14 (RPKM 8.4) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See U2surp in Genome Data Viewer
Location:
9 E3.3; 9 50.11 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (95338947..95394049, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (95456894..95511996, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr9:95326297-95326598 Neighboring gene FCF1 small subunit processome component homolog pseudogene Neighboring gene predicted gene, 32133 Neighboring gene STARR-positive B cell enhancer ABC_E6789 Neighboring gene STARR-seq mESC enhancer starr_24932 Neighboring gene STARR-seq mESC enhancer starr_24934 Neighboring gene progestin and adipoQ receptor family member IX Neighboring gene predicted gene, 32542

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells. Jin L, et al. Nat Commun, 2020 Nov 23. PMID 33230114, Free PMC Article
  2. Phosphoinositide-specific phospholipase C β 1b (PI-PLCβ1b) interactome: affinity purification-mass spectrometry analysis of PI-PLCβ1b with nuclear protein. Piazzi M, et al. Mol Cell Proteomics, 2013 Aug. PMID 23665500, Free PMC Article
  3. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
  4. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
  5. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
U2 snRNP-associated SURP motif-containing protein
Names
140 kDa Ser/Arg-rich domain protein
U2-associated protein SR140

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114977.1 → NP_001108449.1  U2 snRNP-associated SURP motif-containing protein isoform 1

    See identical proteins and their annotated locations for NP_001108449.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC159895
    Consensus CDS
    CCDS52889.1
    UniProtKB/Swiss-Prot
    E9QK93, Q6NV83, Q9CSW7, Q9CT00
    Related
    ENSMUSP00000078602.6, ENSMUST00000079659.12
    Conserved Domains (5) summary
    smart00582
    Location:541 → 676
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    COG0724
    Location:156 → 352
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12223
    Location:273 → 356
    RRM_SR140; RNA recognition motif (RRM) found in U2-associated protein SR140 and similar proteins
    cd21370
    Location:836 → 884
    cwf21_SR140; cwf21 domain found in U2-associated protein SR140 and similar proteins
    pfam01805
    Location:429 → 480
    Surp; Surp module

  2. NM_001357974.1 → NP_001344903.1  U2 snRNP-associated SURP motif-containing protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC159895
    Consensus CDS
    CCDS90640.1
    Related
    ENSMUSP00000151121.2, ENSMUST00000217176.2
    Conserved Domains (5) summary
    smart00582
    Location:540 → 675
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    COG0724
    Location:156 → 351
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12223
    Location:272 → 355
    RRM_SR140; RNA recognition motif (RRM) in U2-associated protein SR140 and similar proteins
    pfam01805
    Location:429 → 479
    Surp; Surp module
    pfam08312
    Location:842 → 883
    cwf21; cwf21 domain

  3. NM_001357975.1 → NP_001344904.1  U2 snRNP-associated SURP motif-containing protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC159895
    Conserved Domains (5) summary
    smart00582
    Location:496 → 631
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    COG0724
    Location:112 → 307
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12223
    Location:228 → 311
    RRM_SR140; RNA recognition motif (RRM) in U2-associated protein SR140 and similar proteins
    pfam01805
    Location:385 → 435
    Surp; Surp module
    pfam08312
    Location:798 → 839
    cwf21; cwf21 domain

  4. NM_001357976.1 → NP_001344905.1  U2 snRNP-associated SURP motif-containing protein isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variant 6, encodes isoform 5.
    Source sequence(s)
    AC159895
    Conserved Domains (3) summary
    smart00582
    Location:132 → 267
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    pfam01805
    Location:19 → 70
    Surp; Surp module
    pfam08312
    Location:434 → 475
    cwf21; cwf21 domain

  5. NM_001357977.1 → NP_001344906.1  U2 snRNP-associated SURP motif-containing protein isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variant 5, encodes isoform 5.
    Source sequence(s)
    AC159895
    Conserved Domains (3) summary
    smart00582
    Location:132 → 267
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    pfam01805
    Location:19 → 70
    Surp; Surp module
    pfam08312
    Location:434 → 475
    cwf21; cwf21 domain

  6. NM_026476.2 → NP_080752.2  U2 snRNP-associated SURP motif-containing protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC159895
    Consensus CDS
    CCDS40727.1
    UniProtKB/Swiss-Prot
    Q6NV83
    Related
    ENSMUSP00000077482.7, ENSMUST00000078374.13
    Conserved Domains (4) summary
    smart00582
    Location:497 → 632
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    cd12223
    Location:229 → 312
    RRM_SR140; RNA recognition motif (RRM) in U2-associated protein SR140 and similar proteins
    pfam01805
    Location:386 → 436
    Surp; Surp module
    pfam08312
    Location:799 → 840
    cwf21; cwf21 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    95338947..95394049 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244532.2 → XP_030100392.1  U2 snRNP-associated SURP motif-containing protein isoform X1

    Conserved Domains (3) summary
    smart00582
    Location:132 → 267
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    pfam01805
    Location:19 → 70
    Surp; Surp module
    pfam08312
    Location:434 → 475
    cwf21; cwf21 domain

  2. XM_030244531.1 → XP_030100391.1  U2 snRNP-associated SURP motif-containing protein isoform X1

    Conserved Domains (3) summary
    smart00582
    Location:132 → 267
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    pfam01805
    Location:19 → 70
    Surp; Surp module
    pfam08312
    Location:434 → 475
    cwf21; cwf21 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NV83.3 GenPept UniProtKB/Swiss-Prot:Q6NV83

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