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Rbm18 RNA binding motif protein 18 [ Mus musculus (house mouse) ]

Gene ID: 67889, updated on 11-Apr-2024

Summary

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Official Symbol
Rbm18provided by MGI
Official Full Name
RNA binding motif protein 18provided by MGI
Primary source
MGI:MGI:1915139
See related
Ensembl:ENSMUSG00000026889 AllianceGenome:MGI:1915139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2010004P11Rik
Summary
Predicted to enable RNA binding activity. Predicted to be located in cytosol; intercellular bridge; and nucleoplasm. Is expressed in central nervous system; lung; and sensory organ. Orthologous to human RBM18 (RNA binding motif protein 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 21.2), whole brain E14.5 (RPKM 21.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rbm18 in Genome Data Viewer
Location:
2 B; 2 24.19 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (36006091..36026716, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (36116079..36136704, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr2:35904821-35905122 Neighboring gene MORN repeat containing 5 Neighboring gene LIM homeobox protein 6 Neighboring gene mitochondrial ribosome recycling factor Neighboring gene predicted gene, 46735 Neighboring gene STARR-positive B cell enhancer ABC_E5908 Neighboring gene prostaglandin-endoperoxide synthase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
probable RNA-binding protein 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159635.1 → NP_001153107.1  probable RNA-binding protein 18 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK035348, BB841783, BE944155, CB183820
    UniProtKB/Swiss-Prot
    Q9CR83
    Conserved Domains (1) summary
    cl17169
    Location:26 → 75
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_001355578.1 → NP_001342507.1  probable RNA-binding protein 18 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL773525
    Conserved Domains (1) summary
    cd12355
    Location:26 → 81
    RRM_RBM18; RNA recognition motif in eukaryotic RNA-binding protein 18 and similar proteins

  3. NM_001355579.1 → NP_001342508.1  probable RNA-binding protein 18 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice junction compared to variant 1, that causes a frameshift. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL773525
    Conserved Domains (1) summary
    cd12355
    Location:26 → 80
    RRM_RBM18; RNA recognition motif in eukaryotic RNA-binding protein 18 and similar proteins

  4. NM_001355580.1 → NP_001342509.1  probable RNA-binding protein 18 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate exon compared to variant 1. The resulting isoform (5) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL773525
    Conserved Domains (1) summary
    cl17169
    Location:12 → 36
    RRM_SF; RNA recognition motif (RRM) superfamily

  5. NM_026434.4 → NP_080710.1  probable RNA-binding protein 18 isoform 1

    See identical proteins and their annotated locations for NP_080710.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK035348, BE944155, CB183820
    Consensus CDS
    CCDS15969.1
    UniProtKB/Swiss-Prot
    Q8CBD4, Q9CR83
    Related
    ENSMUSP00000028251.4, ENSMUST00000028251.10
    Conserved Domains (2) summary
    cd12355
    Location:26 → 105
    RRM_RBM18; RNA recognition motif in eukaryotic RNA-binding protein 18 and similar proteins
    cl25617
    Location:26 → 189
    LSM_int_assoc; LSM-interacting associated unstructured

RNA

  1. NR_027515.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction at the 3' end of an exon compared to variant 1. This results in the transcript being a candidate for nonsense-mediated mRNA decay (NMD), so a protein is not thought to be produced by this transcript.
    Source sequence(s)
    AK035348, BE944155, BY009724, CB183820

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    36006091..36026716 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CR83.1 GenPept UniProtKB/Swiss-Prot:Q9CR83

Gene LinkOut

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