U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Slc38a2 solute carrier family 38, member 2 [ Mus musculus (house mouse) ]

Gene ID: 67760, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Slc38a2provided by MGI
Official Full Name
solute carrier family 38, member 2provided by MGI
Primary source
MGI:MGI:1915010
See related
Ensembl:ENSMUSG00000022462 AllianceGenome:MGI:1915010
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ATA2; SAT2; SNAT2; mKIAA1382; 5033402L14Rik
Summary
Enables L-glutamine transmembrane transporter activity. Involved in glutamine transport. Acts upstream of or within amino acid transport. Located in plasma membrane. Is expressed in several structures, including brain meninges; extraembryonic component; genitourinary system; phalanx; and tooth. Orthologous to human SLC38A2 (solute carrier family 38 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 43.2), limb E14.5 (RPKM 42.7) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Slc38a2 in Genome Data Viewer
Location:
15 F1; 15 52.6 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (96585267..96597609, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (96687392..96699728, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr15:96485346-96485646 Neighboring gene predicted gene, 46503 Neighboring gene STARR-positive B cell enhancer ABC_E9919 Neighboring gene STARR-positive B cell enhancer ABC_E5510 Neighboring gene predicted gene, 22045 Neighboring gene STARR-positive B cell enhancer ABC_E7412 Neighboring gene STARR-seq mESC enhancer starr_39600 Neighboring gene STARR-positive B cell enhancer ABC_E1483 Neighboring gene predicted gene, 32564 Neighboring gene STARR-seq mESC enhancer starr_39603 Neighboring gene predicted gene, 32677

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Neutral amino acid transporter SLC38A2 protects renal medulla from hyperosmolarity-induced ferroptosis. Du C, et al. Elife, 2023 Feb 1. PMID 36722887, Free PMC Article
  2. Placenta-specific Slc38a2/SNAT2 knockdown causes fetal growth restriction in mice. Vaughan OR, et al. Clin Sci (Lond), 2021 Sep 17. PMID 34406367, Free PMC Article
  3. Sodium-coupled neutral amino acid transporter SNAT2 counteracts cardiogenic pulmonary edema by driving alveolar fluid clearance. Weidenfeld S, et al. Am J Physiol Lung Cell Mol Physiol, 2021 Apr 1. PMID 33439101
  4. The amino acid transporter SNAT2 mediates L-proline-induced differentiation of ES cells. Tan BS, et al. Am J Physiol Cell Physiol, 2011 Jun. PMID 21346154
  5. Amino acid sensing by enteroendocrine STC-1 cells: role of the Na+-coupled neutral amino acid transporter 2. Young SH, et al. Am J Physiol Cell Physiol, 2010 Jun. PMID 20219951, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The NERP-4-SNAT2 axis regulates pancreatic beta-cell maintenance and function.
    Title: The NERP-4-SNAT2 axis regulates pancreatic β-cell maintenance and function.
  2. Neutral amino acid transporter SLC38A2 protects renal medulla from hyperosmolarity-induced ferroptosis.
    Title: Neutral amino acid transporter SLC38A2 protects renal medulla from hyperosmolarity-induced ferroptosis.
  3. Placenta-specific Slc38a2/SNAT2 knockdown causes fetal growth restriction in mice.
    Title: Placenta-specific Slc38a2/SNAT2 knockdown causes fetal growth restriction in mice.
  4. Changes in transporter expression likely reflect different amino acid requirements during development. Findings include the differential expression of SNAT1 in the inner and outer cells of the compacted morula and nuclear localisation of SNAT2 in the trophectoderm and placental lineages.
    Title: Regulation of amino acid transporters in pluripotent cell populations in the embryo and in culture; novel roles for sodium-coupled neutral amino acid transporters.
  5. The neuronal mechanism uncovered here serves to coordinate amino acid and lipid levels and contributes to the development of obesity-related hypertriglyceridemia.
    Title: A hepatic amino acid/mTOR/S6K-dependent signalling pathway modulates systemic lipid metabolism via neuronal signals.
  6. GADD34 promotes cell survival and adaptation to increased extracellular osmolarity by increasing the uptake of small neutral amino acids via the amino acid transporter ATA2.
    Title: Coordinated Regulation of the Neutral Amino Acid Transporter SNAT2 and the Protein Phosphatase Subunit GADD34 Promotes Adaptation to Increased Extracellular Osmolarity.
  7. These data reveal an unexpected role for amino acid uptake and the amino acid transporter SNAT2 in regulation of pluripotent cells in culture.
    Title: The amino acid transporter SNAT2 mediates L-proline-induced differentiation of ES cells.
  8. The inward current of Na(+) associated with the function of SNAT2 leads to membrane depolarization and activation of voltage-sensitive Ca(2+) channels that mediate Ca(2+) influx, thereby leading to an increase in the [Ca(2+)](i) in enteroendocrine cells.
    Title: Amino acid sensing by enteroendocrine STC-1 cells: role of the Na+-coupled neutral amino acid transporter 2.
  9. Despite increased ATF4 binding at the C/EBP-ATF composite site following activation of the unfolded protein response, system A transporter 2 (SNAT2) transcription activity is repressed
    Title: Despite increased ATF4 binding at the C/EBP-ATF composite site following activation of the unfolded protein response, system A transporter 2 (SNAT2) transcription activity is repressed in HepG2 cells.
  10. SNAT2 not only regulates mTOR but also regulates proteolysis through PI3K and provides a link among acidosis, insulin resistance, and protein wasting in skeletal muscle cells.
    Title: Inhibition of SNAT2 by metabolic acidosis enhances proteolysis in skeletal muscle.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-glutamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-glutamine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-glutamine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-serine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables acidic amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables alanine:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables amino acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables amino acid:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables neutral L-amino acid transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables neutral L-amino acid:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables proline:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-glutamine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in L-proline import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in L-serine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in L-serine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in alanine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in amino acid import ISO
Inferred from Sequence Orthology
more info
  
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within amino acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amino acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to arsenite(3-) ISO
Inferred from Sequence Orthology
more info
  
involved_in glutamine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutamine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glutamine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in glycine betaine transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in neutral amino acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in proline transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cellular response to stress ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of glutamate secretion, neurotransmission ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in brush border ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
sodium-coupled neutral amino acid symporter 2
Names
amino acid system A transporter
amino acid transporter A2
sodium-coupled neutral amino acid transporter 2
system A amino acid transporter 2
system A transporter 1
system N amino acid transporter 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355633.1 → NP_001342562.1  sodium-coupled neutral amino acid symporter 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC109201
    Conserved Domains (1) summary
    cl00456
    Location:26 → 412
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. NM_175121.4 → NP_780330.2  sodium-coupled neutral amino acid symporter 2 isoform 1

    See identical proteins and their annotated locations for NP_780330.2

    Status: VALIDATED

    Source sequence(s)
    AC109201
    Consensus CDS
    CCDS27778.1
    UniProtKB/Swiss-Prot
    Q3TEX3, Q6PFR1, Q6ZPS7, Q810U9, Q8CC66, Q8CD21, Q8CFE6
    Related
    ENSMUSP00000023099.7, ENSMUST00000023099.8
    Conserved Domains (1) summary
    cl00456
    Location:69 → 491
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    96585267..96597609 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159554.1 → XP_036015447.1  sodium-coupled neutral amino acid symporter 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3TEX3, Q6PFR1, Q6ZPS7, Q810U9, Q8CC66, Q8CD21, Q8CFE6
    Conserved Domains (1) summary
    cl00456
    Location:69 → 491
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CFE6.1 GenPept UniProtKB/Swiss-Prot:Q8CFE6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous