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Cpeb4 cytoplasmic polyadenylation element binding protein 4 [ Mus musculus (house mouse) ]

Gene ID: 67579, updated on 11-Apr-2024

Summary

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Official Symbol
Cpeb4provided by MGI
Official Full Name
cytoplasmic polyadenylation element binding protein 4provided by MGI
Primary source
MGI:MGI:1914829
See related
Ensembl:ENSMUSG00000020300 AllianceGenome:MGI:1914829
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cpeb-4; Cpe-bp4; mCPEB-4
Summary
Enables RNA binding activity. Involved in cellular response to amino acid stimulus and response to ischemia. Located in several cellular components, including dendrite; endoplasmic reticulum; and postsynaptic density. Is expressed in several structures, including central nervous system; dorsal root ganglion; liver; lung; and sensory organ. Orthologous to human CPEB4 (cytoplasmic polyadenylation element binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 15.0), liver E14.5 (RPKM 14.5) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 A4; 11 18.66 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (31820911..31885635)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (31870104..31935635)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D630024D03 gene Neighboring gene STARR-seq mESC enhancer starr_29094 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:31732062-31732171 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:31732356-31732509 Neighboring gene predicted gene, 39675 Neighboring gene predicted gene 12107 Neighboring gene STARR-positive B cell enhancer ABC_E2352 Neighboring gene STARR-positive B cell enhancer mm9_chr11:31822573-31822874 Neighboring gene von Hippel-Lindau binding protein 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2982 Neighboring gene RIKEN cDNA 4930524B15 gene Neighboring gene S-adenosylmethionine decarboxylase, pseudogene 3 pseudogene Neighboring gene predicted gene, 35267

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. mmu-microRNA-92a-3p attenuates pulmonary fibrosis by modulating Cpeb4-mediated Smad2/3 signaling pathway. Shi M, et al. Funct Integr Genomics, 2022 Dec. PMID 35909199
  2. Immune translational control by CPEB4 regulates intestinal inflammation resolution and colorectal cancer development. Sibilio A, et al. iScience, 2022 Feb 18. PMID 35243213, Free PMC Article
  3. The RNA-binding protein Cpeb4 is a novel positive regulator of osteoclast differentiation. Arasaki Y, et al. Biochem Biophys Res Commun, 2020 Aug 6. PMID 32517870
  4. Circadian- and UPR-dependent control of CPEB4 mediates a translational response to counteract hepatic steatosis under ER stress. Maillo C, et al. Nat Cell Biol, 2017 Feb. PMID 28092655
  5. Cpeb4-mediated translational regulatory circuitry controls terminal erythroid differentiation. Hu W, et al. Dev Cell, 2014 Sep 29. PMID 25220394, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CPEB4-CLOCK crosstalk during temporal lobe epilepsy.
    Title: CPEB4-CLOCK crosstalk during temporal lobe epilepsy.
  2. Restoration of CPEB4 prevents muscle stem cell senescence during aging.
    Title: Restoration of CPEB4 prevents muscle stem cell senescence during aging.
  3. Pathogenic Mis-splicing of CPEB4 in Schizophrenia.
    Title: Pathogenic Mis-splicing of CPEB4 in Schizophrenia.
  4. mmu-microRNA-92a-3p attenuates pulmonary fibrosis by modulating Cpeb4-mediated Smad2/3 signaling pathway.
    Title: mmu-microRNA-92a-3p attenuates pulmonary fibrosis by modulating Cpeb4-mediated Smad2/3 signaling pathway.
  5. CPEB4 Increases Expression of PFKFB3 to Induce Glycolysis and Activate Mouse and Human Hepatic Stellate Cells, Promoting Liver Fibrosis.
    Title: CPEB4 Increases Expression of PFKFB3 to Induce Glycolysis and Activate Mouse and Human Hepatic Stellate Cells, Promoting Liver Fibrosis.
  6. The RNA-binding protein Cpeb4 is a novel positive regulator of osteoclast differentiation.
    Title: The RNA-binding protein Cpeb4 is a novel positive regulator of osteoclast differentiation.
  7. Polyadenylation of mRNA as a novel regulatory mechanism of gene expression in temporal lobe epilepsy.
    Title: Polyadenylation of mRNA as a novel regulatory mechanism of gene expression in temporal lobe epilepsy.
  8. that cytoplasmic polyadenylation element-binding protein 4 (CPEB4) acts as a survival factor exclusively for early postnatal granule cells
    Title: Olfactory-Experience- and Developmental-Stage-Dependent Control of CPEB4 Regulates c-Fos mRNA Translation for Granule Cell Survival.
  9. Results show that Cpeb4 is highly expressed in the nervous system including spinal motor neurons. the CPEB4-unstructured low complexity domains (LCD) impairs neuron development that results in reduced motor axon branching and diminished NMJ formation in embryos and uncoordinated movement in neonatal mice.
    Title: Impaired neurodevelopment by the low complexity domain of CPEB4 reveals a convergent pathway with neurodegeneration.
  10. combined transcriptional and translational Cpeb4 regulation generates a 'circadian mediator', which coordinates hepatic UPR activity with periods of high ER-protein-folding demand
    Title: Circadian- and UPR-dependent control of CPEB4 mediates a translational response to counteract hepatic steatosis under ER stress.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • mKIAA1673, 4930447D24Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA regulatory element binding translation repressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation factor activity, RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to amino acid stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to amino acid stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to decreased oxygen levels ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in ionotropic glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to ischemia IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
part_of messenger ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cytoplasmic polyadenylation element-binding protein 4
Names
CPE-binding protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290676.1 → NP_001277605.1  cytoplasmic polyadenylation element-binding protein 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AI845839, AK162101, BC079599, CD803291
    UniProtKB/TrEMBL
    Q3TSF0
    Conserved Domains (3) summary
    cd12724
    Location:464 → 555
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:572 → 652
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:647 → 708
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

  2. NM_001290678.1 → NP_001277607.1  cytoplasmic polyadenylation element-binding protein 4 isoform 3

    See identical proteins and their annotated locations for NP_001277607.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two exons in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AI845839, AK162101, BC079599, CD803291
    UniProtKB/Swiss-Prot
    Q7TN98
    UniProtKB/TrEMBL
    Q3TSF0
    Conserved Domains (3) summary
    cd12724
    Location:447 → 538
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:555 → 635
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:630 → 691
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

  3. NM_026252.4 → NP_080528.2  cytoplasmic polyadenylation element-binding protein 4 isoform 1

    See identical proteins and their annotated locations for NP_080528.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI845839, AK162101, BC079599, CF182456
    Consensus CDS
    CCDS24514.1
    UniProtKB/Swiss-Prot
    A6H6G0, Q69ZD7, Q7TN98
    Related
    ENSMUSP00000020543.7, ENSMUST00000020543.13
    Conserved Domains (3) summary
    cd12724
    Location:472 → 563
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:580 → 660
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:655 → 716
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    31820911..31885635
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514793.3 → XP_006514856.1  cytoplasmic polyadenylation element-binding protein 4 isoform X1

    UniProtKB/TrEMBL
    Q5SU48
    Related
    ENSMUSP00000105039.3, ENSMUST00000109412.9
    Conserved Domains (3) summary
    cd12724
    Location:455 → 546
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:563 → 643
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:638 → 699
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TN98.1 GenPept UniProtKB/Swiss-Prot:Q7TN98

Gene LinkOut

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