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Pabpc6 poly(A) binding protein, cytoplasmic 6 [ Mus musculus (house mouse) ]

Gene ID: 67543, updated on 5-Mar-2024

Summary

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Official Symbol
Pabpc6provided by MGI
Official Full Name
poly(A) binding protein, cytoplasmic 6provided by MGI
Primary source
MGI:MGI:1914793
See related
Ensembl:ENSMUSG00000046173 AllianceGenome:MGI:1914793
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pabpc3; 4932702K14Rik
Summary
Predicted to enable RNA binding activity and protein C-terminus binding activity. Predicted to be located in cell leading edge and cytoplasmic ribonucleoprotein granule. Predicted to be part of catalytic step 2 spliceosome. Predicted to be active in cytoplasmic stress granule; cytosol; and nucleus. Is expressed in several structures, including alimentary system; brain; nose; urinary system; and vibrissa. Orthologous to human PABPC1 (poly(A) binding protein cytoplasmic 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
17 A1; 17 7.47 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (9885426..9888633, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (9666497..9669704, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7947 Neighboring gene STARR-seq mESC enhancer starr_41777 Neighboring gene STARR-seq mESC enhancer starr_41778 Neighboring gene STARR-seq mESC enhancer starr_41779 Neighboring gene predicted gene, 51424 Neighboring gene predicted gene, 17748 Neighboring gene STARR-seq mESC enhancer starr_41780 Neighboring gene STARR-seq mESC enhancer starr_41781 Neighboring gene STARR-seq mESC enhancer starr_41782 Neighboring gene STARR-seq mESC enhancer starr_41784 Neighboring gene STARR-seq mESC enhancer starr_41785 Neighboring gene predicted gene, 34684 Neighboring gene RIKEN cDNA 4930452A19 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC132900

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(U) RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
poly(A) binding protein, cytoplasmic 3
Names
poly A binding protein, cytoplasmic 1 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163836.1 → NP_001157308.1  poly(A) binding protein, cytoplasmic 3

    See identical proteins and their annotated locations for NP_001157308.1

    Status: VALIDATED

    Source sequence(s)
    AC134446, AK016578, AK029765
    Consensus CDS
    CCDS49946.1
    UniProtKB/TrEMBL
    Q9D4E6
    Related
    ENSMUSP00000050792.3, ENSMUST00000057190.4
    Conserved Domains (6) summary
    TIGR01628
    Location:11 → 622
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12378
    Location:12 → 91
    RRM1_I_PABPs; RNA recognition motif 1 in type I polyadenylate-binding proteins
    cd12379
    Location:97 → 172
    RRM2_I_PABPs; RNA recognition motif 2 found in type I polyadenylate-binding proteins
    cd12380
    Location:190 → 269
    RRM3_I_PABPs; RNA recognition motif 3 found in type I polyadenylate-binding proteins
    cd12381
    Location:303 → 380
    RRM4_I_PABPs; RNA recognition motif 4 in type I polyadenylate-binding proteins
    pfam00658
    Location:554 → 621
    PABP; Poly-adenylate binding protein, unique domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    9885426..9888633 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_026226.2: Suppressed sequence

    Description
    NM_026226.2: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.

  2. NR_003636.1: Suppressed sequence

    Description
    NR_003636.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Nucleotide Protein Strain
Heading Accession and Version

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