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Ergic2 ERGIC and golgi 2 [ Mus musculus (house mouse) ]

Gene ID: 67456, updated on 21-Apr-2024

Summary

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Official Symbol
Ergic2provided by MGI
Official Full Name
ERGIC and golgi 2provided by MGI
Primary source
MGI:MGI:1914706
See related
Ensembl:ENSMUSG00000030304 AllianceGenome:MGI:1914706
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ptx1; 1200009B18Rik; 4930572C01Rik
Summary
Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to act upstream of or within vesicle-mediated transport. Predicted to be located in Golgi apparatus and nucleolus. Predicted to be active in COPII-coated ER to Golgi transport vesicle; endoplasmic reticulum; and membrane. Orthologous to human ERGIC2 (ERGIC and golgi 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 11.8), testis adult (RPKM 11.7) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 G3; 6 78.49 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (148080816..148113886, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (148179318..148212388, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15762 Neighboring gene STARR-seq mESC enhancer starr_17826 Neighboring gene STARR-seq mESC enhancer starr_17827 Neighboring gene fatty acyl CoA reductase 2, opposite strand 1 Neighboring gene STARR-seq mESC enhancer starr_17828 Neighboring gene fatty acyl CoA reductase 2 Neighboring gene STARR-seq mESC enhancer starr_17829 Neighboring gene STARR-seq mESC enhancer starr_17830 Neighboring gene RIKEN cDNA 4732416N19 gene Neighboring gene STARR-positive B cell enhancer ABC_E540 Neighboring gene STARR-positive B cell enhancer ABC_E3694 Neighboring gene predicted gene, 52483 Neighboring gene transmembrane and tetratricopeptide repeat containing 1 Neighboring gene STARR-seq mESC enhancer starr_17834 Neighboring gene ribosomal protein S4-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ERGIC2 and ERGIC3 regulate the ER-to-Golgi transport of gap junction proteins in metazoans. Guan L, et al. Traffic, 2022 Mar. PMID 34994051
  2. Ergic2, a brain specific interacting partner of Otoferlin. Żak M, et al. Cell Physiol Biochem, 2012. PMID 22613993
  3. The human IL-3/granulocyte-macrophage colony-stimulating factor locus is epigenetically silent in immature thymocytes and is progressively activated during T cell development. Mirabella F, et al. J Immunol, 2010 Mar 15. PMID 20147630
  4. Hoxa2 plays a direct role in murine palate development. Smith TM, et al. Dev Dyn, 2009 Sep. PMID 19653318
  5. Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Hrabé de Angelis MH, et al. Nat Genet, 2000 Aug. PMID 10932192

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in COPII-coated ER to Golgi transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of retrograde transporter complex, Golgi to ER ISO
Inferred from Sequence Orthology
more info
  
part_of transporter complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
endoplasmic reticulum-Golgi intermediate compartment protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286560.1 → NP_001273489.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC132613, AK016275, AK030045, AK162267
    UniProtKB/Swiss-Prot
    Q9CR89
    Conserved Domains (1) summary
    pfam07970
    Location:87 → 249
    COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter

  2. NM_026168.4 → NP_080444.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform 1

    See identical proteins and their annotated locations for NP_080444.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC132613, AK016275, AK030045
    Consensus CDS
    CCDS20708.1
    UniProtKB/Swiss-Prot
    B2KFC8, Q3UX13, Q9CR89, Q9CWM6, Q9CYA2, Q9D4R1, Q9D8Z9
    Related
    ENSMUSP00000120456.2, ENSMUST00000136008.8
    Conserved Domains (2) summary
    pfam07970
    Location:170 → 332
    COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
    pfam13850
    Location:13 → 95
    ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    148080816..148113886 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255556.1 → XP_030111416.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X2

    Conserved Domains (2) summary
    pfam07970
    Location:170 → 322
    COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
    pfam13850
    Location:13 → 95
    ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

  2. XM_006507089.5 → XP_006507152.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006507152.1

    Conserved Domains (2) summary
    pfam07970
    Location:170 → 322
    COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
    pfam13850
    Location:13 → 95
    ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

  3. XM_030255558.2 → XP_030111418.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X6

    Conserved Domains (1) summary
    pfam07970
    Location:71 → 233
    COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter

  4. XM_030255557.2 → XP_030111417.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X4

    Conserved Domains (1) summary
    pfam07970
    Location:87 → 249
    COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter

  5. XM_030255560.2 → XP_030111420.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X7

    Conserved Domains (1) summary
    pfam07970
    Location:45 → 207
    COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter

  6. XM_030255559.2 → XP_030111419.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X6

    Conserved Domains (1) summary
    pfam07970
    Location:71 → 233
    COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter

  7. XM_030255561.2 → XP_030111421.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X8

    UniProtKB/TrEMBL
    A0A0N4SVQ6
    Related
    ENSMUSP00000145204.2, ENSMUST00000203268.2
    Conserved Domains (1) summary
    pfam07970
    Location:45 → 197
    COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter

  8. XM_017321716.3 → XP_017177205.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B2KFC8, Q3UX13, Q9CR89, Q9CWM6, Q9CYA2, Q9D4R1, Q9D8Z9
    Conserved Domains (2) summary
    pfam07970
    Location:170 → 332
    COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
    pfam13850
    Location:13 → 95
    ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

  9. XM_017321717.1 → XP_017177206.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X3

    UniProtKB/Swiss-Prot
    Q9CR89
    Conserved Domains (2) summary
    pfam07970
    Location:170 → 280
    COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
    pfam13850
    Location:13 → 95
    ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

  10. XM_011241623.3 → XP_011239925.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X5

    See identical proteins and their annotated locations for XP_011239925.1

    Conserved Domains (2) summary
    pfam07970
    Location:170 → 270
    COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
    pfam13850
    Location:13 → 95
    ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

RNA

  1. XR_001785162.2 RNA Sequence

  2. XR_378169.5 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_026355.3: Suppressed sequence

    Description
    NM_026355.3: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CR89.1 GenPept UniProtKB/Swiss-Prot:Q9CR89

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