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SRP19 signal recognition particle 19 [ Homo sapiens (human) ]

Gene ID: 6728, updated on 4-Jan-2025

Summary

Official Symbol
SRP19provided by HGNC
Official Full Name
signal recognition particle 19provided by HGNC
Primary source
HGNC:HGNC:11300
See related
Ensembl:ENSG00000153037 MIM:182175; AllianceGenome:HGNC:11300
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables 7S RNA binding activity. Contributes to ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Located in cytosol; nuclear body; and nucleolus. Part of signal recognition particle, endoplasmic reticulum targeting. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in thyroid (RPKM 11.2), bone marrow (RPKM 8.6) and 25 other tissues See more
Orthologs
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Genomic context

See SRP19 in Genome Data Viewer
Location:
5q22.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (112861287..112898371)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (113371827..113408903)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (112196984..112234068)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene APC regulator of WNT signaling pathway Neighboring gene RNA, U6 small nuclear 482, pseudogene Neighboring gene CBX3 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 9882 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:112226954-112228153 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16238 Neighboring gene receptor accessory protein 5 Neighboring gene X-box binding protein 1 pseudogene 1 Neighboring gene ZRSR2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16240 Neighboring gene uncharacterized LOC105379123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22913 Neighboring gene MPRA-validated peak5421 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16241 Neighboring gene Sharpr-MPRA regulatory region 12983 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22914 Neighboring gene uncharacterized LOC105379126

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
nucleocapsid gag Overexpression of SRP19 reduces the HIV-1 NC-mediated packaging of 7SL RNA and A3G into virions in a dose-dependent manner PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 7S RNA binding  
enables 7S RNA binding PubMed 
enables RNA binding PubMed 
enables RNA binding PubMed 
enables protein binding PubMed 
contributes_to ribosome binding PubMed 
Component Evidence Code Pubs
located_in cytosol  
located_in cytosol  
located_in nuclear body  
located_in nucleolus PubMed 
part_of signal recognition particle PubMed 
part_of signal recognition particle, endoplasmic reticulum targeting  
part_of signal recognition particle, endoplasmic reticulum targeting PubMed 

General protein information

Preferred Names
signal recognition particle 19 kDa protein
Names
signal recognition particle 19kD
signal recognition particle 19kDa
NP_001191122.1
NP_001191123.1
NP_001191125.1
NP_001191128.1
NP_003126.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204193.2NP_001191122.1  signal recognition particle 19 kDa protein isoform 2

    See identical proteins and their annotated locations for NP_001191122.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AA845342, AC008575, AW890522, BC017830, CN265235
    Consensus CDS
    CCDS56375.1
    UniProtKB/TrEMBL
    A0A087WWU9
    Related
    ENSP00000282999.3, ENST00000282999.7
    Conserved Domains (1) summary
    pfam01922
    Location:17100
    SRP19; SRP19 protein
  2. NM_001204194.2NP_001191123.1  signal recognition particle 19 kDa protein isoform 3

    See identical proteins and their annotated locations for NP_001191123.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AA845342, AC008575, AW890522, CN265235, DN915735, X12791
    Consensus CDS
    CCDS75286.1
    UniProtKB/TrEMBL
    A0A087WYR0
    Related
    ENSP00000482018.1, ENST00000621420.5
    Conserved Domains (1) summary
    pfam01922
    Location:1791
    SRP19; SRP19 protein
  3. NM_001204196.2NP_001191125.1  signal recognition particle 19 kDa protein isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon that results in a frameshift in the central and 3' coding regions, compared to variant 1. The encoded isoform (4) has the same N-terminus but is otherwise distinct and shorter, compared to isoform 1.
    Source sequence(s)
    AA845342, AC008575, AW890522, BU661702, CN265235
    Consensus CDS
    CCDS56376.1
    UniProtKB/Swiss-Prot
    P09132
    Related
    ENSP00000425562.1, ENST00000515463.1
  4. NM_001204199.2NP_001191128.1  signal recognition particle 19 kDa protein isoform 6

    See identical proteins and their annotated locations for NP_001191128.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 3' coding region and 3' UTR, compared to variant 1, resulting in an isoform (6) with a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AC008536, AC008575, DA930867
    Consensus CDS
    CCDS87319.1
    UniProtKB/TrEMBL
    A0A087WWU9, A0A2U3TZN1
    Related
    ENSP00000375133.2, ENST00000391338.3
    Conserved Domains (1) summary
    pfam01922
    Location:17101
    SRP19; SRP19 protein
  5. NM_003135.3NP_003126.1  signal recognition particle 19 kDa protein isoform 1

    See identical proteins and their annotated locations for NP_003126.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA845342, AC008575, AW890522, CN265235, X12791
    Consensus CDS
    CCDS4108.1
    UniProtKB/Swiss-Prot
    B2R4E9, D6RCQ5, P09132, Q05D77, Q96FG6
    Related
    ENSP00000424870.1, ENST00000505459.6
    Conserved Domains (1) summary
    pfam01922
    Location:17115
    SRP19; SRP19 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    112861287..112898371
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    113371827..113408903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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