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Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 [ Mus musculus (house mouse) ]

Gene ID: 67264, updated on 5-Apr-2024

Summary

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Official Symbol
Ndufb8provided by MGI
Official Full Name
NADH:ubiquinone oxidoreductase subunit B8provided by MGI
Primary source
MGI:MGI:1914514
See related
Ensembl:ENSMUSG00000025204 AllianceGenome:MGI:1914514
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CI-ASHI; 2900010I05Rik
Summary
Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Part of mitochondrial respiratory chain complex I. Is expressed in several structures, including alimentary system; integumental system; nervous system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 32. Orthologous to human NDUFB8 (NADH:ubiquinone oxidoreductase subunit B8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 237.7), kidney adult (RPKM 174.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 C3; 19 37.98 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (44537010..44543881, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (44548571..44555442, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene wingless-type MMTV integration site family, member 8B Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:44587253-44587525 Neighboring gene SEC31 homolog B, COPII coat complex component Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:44637138-44637321 Neighboring gene hypoxia-inducible factor 1, alpha subunit inhibitor Neighboring gene STARR-seq mESC enhancer starr_46238 Neighboring gene predicted gene, 35460

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Reduced levels of mitochondrial complex I subunit NDUFB8 and linked complex I + III oxidoreductase activity in the TgCRND8 mouse model of Alzheimer's disease. Francis BM, et al. J Alzheimers Dis, 2014. PMID 24217272
  2. Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis. Hangen E, et al. Mol Cell, 2015 Jun 18. PMID 26004228
  3. A concerted metabolic shift in early forebrain alters the CSF proteome and depends on MYC downregulation for mitochondrial maturation. Fame RM, et al. Development, 2019 Oct 24. PMID 31575649, Free PMC Article
  4. Perinatal Licensing of Thermogenesis by IL-33 and ST2. Odegaard JI, et al. Cell, 2016 Aug 11. PMID 27453471, Free PMC Article
  5. FBXL4 deficiency increases mitochondrial removal by autophagy. Alsina D, et al. EMBO Mol Med, 2020 Jul 7. PMID 32525278, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. study reports mitochondrial dysfunction in TgCRND8 mouse model of Alzheimer's disease and identifies the NDUFB8 subunit of complex I as a key target of A-beta toxicity
    Title: Reduced levels of mitochondrial complex I subunit NDUFB8 and linked complex I + III oxidoreductase activity in the TgCRND8 mouse model of Alzheimer's disease.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in aerobic respiration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitochondrial electron transport, NADH to ubiquinone IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in proton motive force-driven mitochondrial ATP synthesis NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial respiratory chain complex I IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in respirasome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
Names
NADH dehydrogenase (ubiquinone) 1 beta subcomplex 8
NADH-ubiquinone oxidoreductase ASHI subunit
complex I-ASHI
NP_001334376.1
NP_080337.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347447.1 → NP_001334376.1  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC151478
    Consensus CDS
    CCDS84446.1
    UniProtKB/TrEMBL
    Q3V406
    Related
    ENSMUSP00000128192.2, ENSMUST00000171415.8

  2. NM_026061.3 → NP_080337.1  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_080337.1

    Status: VALIDATED

    Source sequence(s)
    AC151478
    Consensus CDS
    CCDS29851.1
    UniProtKB/Swiss-Prot
    Q9D6J5, Q9D6M7
    Related
    ENSMUSP00000026222.5, ENSMUST00000026222.11
    Conserved Domains (1) summary
    pfam05821
    Location:21 → 186
    NDUF_B8; NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    44537010..44543881 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D6J5.1 GenPept UniProtKB/Swiss-Prot:Q9D6J5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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