Lpar6 lysophosphatidic acid receptor 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lpar6provided by MGI
Official Full Name: lysophosphatidic acid receptor 6provided by MGI
Primary source: MGI:MGI:1914418
See related: Ensembl:ENSMUSG00000033446 AllianceGenome:MGI:1914418
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P2y5; P2ry5; 2610302I02Rik
Summary: Predicted to enable lysophosphatidic acid receptor activity. Acts upstream of or within blastocyst hatching. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Human ortholog(s) of this gene implicated in hypotrichosis. Orthologous to human LPAR6 (lysophosphatidic acid receptor 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 14 D3; 14 38.75 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (73475331..73477798)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (73237891..73240358)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LPA6-RhoA signals regulate junctional complexes for polarity and morphology establishment of maturation stage ameloblasts.
Title: LPA(6)-RhoA signals regulate junctional complexes for polarity and morphology establishment of maturation stage ameloblasts.
the Galpha12/Galpha13-coupled receptors LPA4 and LPA6 synergistically regulate endothelial Dll4 expression through YAP/TAZ activation
Title: Lysophosphatidic acid-induced YAP/TAZ activation promotes developmental angiogenesis by repressing Notch ligand Dll4.
the up-regulation of serum ATX in hepatic encephalopathy may activate the LPA-LPA6-G12/13-Rho pathway in brain capillary endothelial cells.
Title: Lysophosphatidic acid receptor, LPA(6), regulates endothelial blood-brain barrier function: Implication for hepatic encephalopathy.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables lysophosphatidic acid receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blastocyst hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lysophosphatidic acid receptor 6

Names: LPA receptor 6; LPA-6; P2Y purinoceptor 5; oleoyl-L-alpha-lysophosphatidic acid receptor; purinergic receptor (family A group 5); purinergic receptor 5; purinergic receptor P2Y, G-protein coupled, 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175116.4 → NP_780325.1 lysophosphatidic acid receptor 6

See identical proteins and their annotated locations for NP_780325.1

Status: VALIDATED

Source sequence(s)

AC154718

Consensus CDS

CCDS27268.1

UniProtKB/Swiss-Prot

A6H6N5, Q3TEJ6, Q8BMC0

Related

ENSMUSP00000042327.7, ENSMUST00000044405.8

Conserved Domains (2) summary

pfam00001
Location:35 → 291

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:29 → 142

7tm_4; Olfactory receptor