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Ttc14 tetratricopeptide repeat domain 14 [ Mus musculus (house mouse) ]

Gene ID: 67120, updated on 3-Apr-2024

Summary

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Official Symbol
Ttc14provided by MGI
Official Full Name
tetratricopeptide repeat domain 14provided by MGI
Primary source
MGI:MGI:1914370
See related
Ensembl:ENSMUSG00000027677 AllianceGenome:MGI:1914370
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
cI-44; mKIAA1980; 2700016E08Rik; 4930434D01Rik; 4931403I22Rik; 4933402I15Rik
Summary
Predicted to enable nucleic acid binding activity. Orthologous to human TTC14 (tetratricopeptide repeat domain 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 13.0), cortex adult (RPKM 11.9) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 A3; 3 16.32 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (33853923..33869009)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (33799798..33814860)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42203 Neighboring gene heat shock protein 1 (chaperonin) pseudogene Neighboring gene coiled-coil domain containing 39 Neighboring gene STARR-seq mESC enhancer starr_07362 Neighboring gene predicted gene, 42204 Neighboring gene STARR-positive B cell enhancer ABC_E11180 Neighboring gene predicted gene, 23175

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of cAMP analogue inducible genes in RAW264 macrophages. Takahashi Y, et al. Biochim Biophys Acta, 2000 Jul 24. PMID 11004510
  2. Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics. Lamberti A, et al. Biochimie, 2011 Oct. PMID 21689717
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1980

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
tetratricopeptide repeat protein 14
Names
TPR repeat protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290500.2 → NP_001277429.1  tetratricopeptide repeat protein 14 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC154395
    Consensus CDS
    CCDS71232.1
    UniProtKB/Swiss-Prot
    G3X9T5, Q69Z51, Q8BRX6, Q8CD24, Q8CDF8, Q8R3Q9, Q9CSP9
    UniProtKB/TrEMBL
    E9PXW3
    Related
    ENSMUSP00000112450.4, ENSMUST00000117915.8
    Conserved Domains (4) summary
    smart00316
    Location:123 → 206
    S1; Ribosomal protein S1-like RNA-binding domain
    sd00006
    Location:254 → 282
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:288 → 321
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:254 → 319
    TPR_11; TPR repeat

  2. NM_001290502.2 → NP_001277431.1  tetratricopeptide repeat protein 14 isoform d

    See identical proteins and their annotated locations for NP_001277431.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in both UTRs, uses an alternate splice site in the 5' coding region and an alternate 3' terminal exon. These difference cause translation initiation at an alternate start codon compared to variant 1. The encoded isoform (d) is shorter and has novel N- and C-termini compared to isoform a.
    Source sequence(s)
    AC154395
    Consensus CDS
    CCDS79895.1
    UniProtKB/TrEMBL
    A0A0G2JGX7
    Related
    ENSMUSP00000143738.2, ENSMUST00000200271.5
    Conserved Domains (4) summary
    smart00316
    Location:120 → 203
    S1; Ribosomal protein S1-like RNA-binding domain
    sd00006
    Location:303 → 331
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:337 → 370
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:303 → 368
    TPR_11; TPR repeat

  3. NM_001404037.1 → NP_001390966.1  tetratricopeptide repeat protein 14 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC154395

  4. NM_001404038.1 → NP_001390967.1  tetratricopeptide repeat protein 14 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC154395

  5. NM_001404039.1 → NP_001390968.1  tetratricopeptide repeat protein 14 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC154395
    Related
    ENSMUSP00000142863.2, ENSMUST00000196369.2

  6. NM_001404040.1 → NP_001390969.1  tetratricopeptide repeat protein 14 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC154395

  7. NM_001404041.1 → NP_001390970.1  tetratricopeptide repeat protein 14 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC154395

  8. NM_001404042.1 → NP_001390971.1  tetratricopeptide repeat protein 14 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC154395

  9. NM_025978.5 → NP_080254.2  tetratricopeptide repeat protein 14 isoform b

    See identical proteins and their annotated locations for NP_080254.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate structure in the 3' UTR and 3' coding region compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC154395
    Consensus CDS
    CCDS17303.1
    UniProtKB/TrEMBL
    A0A0G2JE97, A6H6N9
    Related
    ENSMUSP00000096757.4, ENSMUST00000099153.10
    Conserved Domains (4) summary
    smart00316
    Location:123 → 206
    S1; Ribosomal protein S1-like RNA-binding domain
    sd00006
    Location:306 → 334
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:340 → 373
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:306 → 371
    TPR_11; TPR repeat

  10. NM_027619.5 → NP_081895.2  tetratricopeptide repeat protein 14 isoform a

    See identical proteins and their annotated locations for NP_081895.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform (a).
    Source sequence(s)
    AC154395
    Consensus CDS
    CCDS38410.1
    UniProtKB/Swiss-Prot
    G3X9T5, Q69Z51, Q8BRX6, Q8CD24, Q8CDF8, Q8R3Q9, Q9CSP9
    UniProtKB/TrEMBL
    A0A8V5I5B0
    Related
    ENSMUSP00000103845.5, ENSMUST00000108210.9
    Conserved Domains (4) summary
    smart00316
    Location:123 → 206
    S1; Ribosomal protein S1-like RNA-binding domain
    sd00006
    Location:306 → 334
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:340 → 373
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:306 → 371
    TPR_11; TPR repeat

RNA

  1. NR_175794.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154395

  2. NR_175795.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154395

  3. NR_175796.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154395

  4. NR_175797.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154395

  5. NR_175798.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154395

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    33853923..33869009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163240.1 → XP_036019133.1  tetratricopeptide repeat protein 14 isoform X7

    UniProtKB/TrEMBL
    A0A0G2JEX0, A0A0G2JF90
    Related
    ENSMUSP00000142935.2, ENSMUST00000199222.5
    Conserved Domains (3) summary
    smart00316
    Location:123 → 206
    S1; Ribosomal protein S1-like RNA-binding domain
    COG0457
    Location:289 → 430
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:306 → 334
    TPR; TPR repeat [structural motif]

  2. XM_006535522.4 → XP_006535585.1  tetratricopeptide repeat protein 14 isoform X1

    UniProtKB/Swiss-Prot
    G3X9T5, Q69Z51, Q8BRX6, Q8CD24, Q8CDF8, Q8R3Q9, Q9CSP9
    Conserved Domains (3) summary
    smart00316
    Location:154 → 237
    S1; Ribosomal protein S1-like RNA-binding domain
    COG0457
    Location:256 → 415
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:285 → 313
    TPR; TPR repeat [structural motif]

  3. XM_011249707.4 → XP_011248009.1  tetratricopeptide repeat protein 14 isoform X6

    UniProtKB/TrEMBL
    A0A0G2JF90
    Conserved Domains (3) summary
    smart00316
    Location:154 → 237
    S1; Ribosomal protein S1-like RNA-binding domain
    COG0457
    Location:320 → 461
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:337 → 365
    TPR; TPR repeat [structural motif]

  4. XM_011249706.4 → XP_011248008.1  tetratricopeptide repeat protein 14 isoform X5

    UniProtKB/TrEMBL
    A0A0G2JF90
    Conserved Domains (3) summary
    smart00316
    Location:154 → 237
    S1; Ribosomal protein S1-like RNA-binding domain
    COG0457
    Location:320 → 473
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:337 → 365
    TPR; TPR repeat [structural motif]

  5. XM_036163238.1 → XP_036019131.1  tetratricopeptide repeat protein 14 isoform X3

    Conserved Domains (3) summary
    COG0457
    Location:75 → 222
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:92 → 120
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:102 → 140
    TPR_11; TPR repeat

  6. XM_030252768.2 → XP_030108628.1  tetratricopeptide repeat protein 14 isoform X4

    Conserved Domains (3) summary
    COG0457
    Location:11 → 170
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:40 → 68
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:50 → 88
    TPR_11; TPR repeat

RNA

  1. XR_880651.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CSP9.3 GenPept UniProtKB/Swiss-Prot:Q9CSP9

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