Ptgr1 prostaglandin reductase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptgr1provided by MGI
Official Full Name: prostaglandin reductase 1provided by MGI
Primary source: MGI:MGI:1914353
See related: Ensembl:ENSMUSG00000028378 AllianceGenome:MGI:1914353
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DIG-1; Zadh3; Ltb4dh; 2510002C21Rik
Summary: Predicted to enable 13-prostaglandin reductase activity; 15-oxoprostaglandin 13-oxidase activity; and 2-alkenal reductase (NADP+) activity. Predicted to be involved in prostaglandin metabolic process. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be located in cytoplasm. Is expressed in genitourinary system. Orthologous to human PTGR1 (prostaglandin reductase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in bladder adult (RPKM 46.6), stomach adult (RPKM 29.1) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 B3; 4 32.36 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (58965590..58987131, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (58965590..58987131, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 13-prostaglandin reductase activity	ISO Inferred from Sequence Orthology more info
enables 15-oxoprostaglandin 13-oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 2-alkenal reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables 2-alkenal reductase [NAD(P)+] activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in prostaglandin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in prostaglandin metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: prostaglandin reductase 1

Names: 15-oxoprostaglandin 13-reductase; D3T-inducible gene 1 protein; NAD(P)H-dependent alkenal/one oxidoreductase; NADP-dependent leukotriene B4 12-hydroxydehydrogenase; PRG-1; dithiolethione-inducible gene 1 protein; leukotriene B4 12-hydroxydehydrogenase

NP_080244.1

EC 1.3.1.48

EC 1.3.1.74

XP_011248390.1

EC 1.3.1.48

EC 1.3.1.74

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025968.3 → NP_080244.1 prostaglandin reductase 1

See identical proteins and their annotated locations for NP_080244.1

Status: PROVISIONAL

Source sequence(s)

AK035425

Consensus CDS

CCDS18215.1

UniProtKB/Swiss-Prot

Q3TKT6, Q91YR9, Q9CPS1

UniProtKB/TrEMBL

Q4FJY5

Related

ENSMUSP00000030069.7, ENSMUST00000030069.7

Conserved Domains (2) summary

TIGR02825
Location:4 → 328

B4_12hDH; leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase

cd08294
Location:2 → 329

leukotriene_B4_DH_like; 13-PGR is a bifunctional enzyme with delta-13 15-prostaglandin reductase and leukotriene B4 12 hydroxydehydrogenase activity

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

58965590..58987131 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011250088.1 → XP_011248390.1 prostaglandin reductase 1 isoform X1

Conserved Domains (1) summary

TIGR02825
Location:4 → 263

B4_12hDH; leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase