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Rps6ka6 ribosomal protein S6 kinase polypeptide 6 [ Mus musculus (house mouse) ]

Gene ID: 67071, updated on 11-Apr-2024

Summary

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Official Symbol
Rps6ka6provided by MGI
Official Full Name
ribosomal protein S6 kinase polypeptide 6provided by MGI
Primary source
MGI:MGI:1914321
See related
Ensembl:ENSMUSG00000025665 AllianceGenome:MGI:1914321
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RSK4; S6K-alpha-6; 2610524K04Rik
Summary
Predicted to enable ribosomal protein S6 kinase activity. Involved in negative regulation of ERK1 and ERK2 cascade; negative regulation of embryonic development; and negative regulation of mesoderm development. Predicted to be located in fibrillar center and mitochondrion. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in several structures, including genitourinary system; nervous system; nose; respiratory system; and thymus primordium. Orthologous to human RPS6KA6 (ribosomal protein S6 kinase A6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 15.3), CNS E11.5 (RPKM 4.6) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X E1; X 48.2 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (110297534..110447794, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (111387837..111538097, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene developmental pluripotency associated 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47771 Neighboring gene STARR-seq mESC enhancer starr_47772 Neighboring gene nuclear encoded tRNA arginine 4 (anticodon CCT) Neighboring gene predicted gene 7340 Neighboring gene highly divergent homeobox

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of mouse Rsk4 as an inhibitor of fibroblast growth factor-RAS-extracellular signal-regulated kinase signaling. Myers AP, et al. Mol Cell Biol, 2004 May. PMID 15121846, Free PMC Article
  2. Down-regulation of TRAF4 targeting RSK4 inhibits proliferation, invasion and metastasis in breast cancer xenografts. Zhu L, et al. Biochem Biophys Res Commun, 2018 Jun 7. PMID 29684350
  3. Expression pattern of the Rsk2, Rsk4 and Pdk1 genes during murine embryogenesis. Kohn M, et al. Gene Expr Patterns, 2003 May. PMID 12711546
  4. The RSK2-RPS6 axis promotes axonal regeneration in the peripheral and central nervous systems. Decourt C, et al. PLoS Biol, 2023 Apr. PMID 37068088, Free PMC Article
  5. RSK2 is a modulator of craniofacial development. Laugel-Haushalter V, et al. PLoS One, 2014. PMID 24416220, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRAF4 knockdown significantly inhibited proliferation, invasion and metastasis in the xenograft nude mouse model, possibly involving in the interaction with RSK4.
    Title: Down-regulation of TRAF4 targeting RSK4 inhibits proliferation, invasion and metastasis in breast cancer xenografts.
  2. Rsk4 inhibits the transcriptional activation of specific targets of receptor tyrosine kinase signaling as well as the activation of ERK
    Title: Characterization of mouse Rsk4 as an inhibitor of fibroblast growth factor-RAS-extracellular signal-regulated kinase signaling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribosomal protein S6 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of embryonic development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of mesoderm development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ribosomal protein S6 kinase alpha-6
NP_001361636.2
NP_001385703.1
NP_080225.2
XP_006528463.1
XP_006528464.1
XP_006528465.1
XP_006528466.1
XP_011246008.1
XP_011246009.1
XP_030107348.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374707.3 → NP_001361636.2  ribosomal protein S6 kinase alpha-6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CR392009
    UniProtKB/TrEMBL
    A2CEE7
    Related
    ENSMUSP00000094073.5, ENSMUST00000096348.10

  2. NM_001398774.1 → NP_001385703.1  ribosomal protein S6 kinase alpha-6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    CR392009
    UniProtKB/TrEMBL
    E9PUP0
    Related
    ENSMUSP00000109055.4, ENSMUST00000113428.9

  3. NM_025949.3 → NP_080225.2  ribosomal protein S6 kinase alpha-6 isoform 1

    See identical proteins and their annotated locations for NP_080225.2

    Status: VALIDATED

    Source sequence(s)
    AK012150, AK049349, BC054113, BY096109, CR392009
    Consensus CDS
    CCDS30356.1
    UniProtKB/Swiss-Prot
    Q7TPS0, Q8BWZ2, Q9CUR6
    UniProtKB/TrEMBL
    B1B0X3, E9QK39
    Related
    ENSMUSP00000115975.3, ENSMUST00000123951.9
    Conserved Domains (2) summary
    cd05582
    Location:193 → 507
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14091
    Location:542 → 828
    STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    110297534..110447794 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247706.4 → XP_011246008.1  ribosomal protein S6 kinase alpha-6 isoform X4

    UniProtKB/Swiss-Prot
    Q7TPS0, Q8BWZ2, Q9CUR6
    Conserved Domains (2) summary
    cd05582
    Location:109 → 423
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14091
    Location:458 → 744
    STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases

  2. XM_006528403.4 → XP_006528466.1  ribosomal protein S6 kinase alpha-6 isoform X3

    UniProtKB/TrEMBL
    A2CEE5
    Conserved Domains (2) summary
    cd05582
    Location:172 → 486
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14091
    Location:521 → 807
    STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases

  3. XM_006528402.4 → XP_006528465.1  ribosomal protein S6 kinase alpha-6 isoform X2

    UniProtKB/Swiss-Prot
    Q7TPS0, Q8BWZ2, Q9CUR6
    Conserved Domains (2) summary
    cd05582
    Location:193 → 507
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14091
    Location:542 → 823
    STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases

  4. XM_006528401.5 → XP_006528464.1  ribosomal protein S6 kinase alpha-6 isoform X1

    See identical proteins and their annotated locations for XP_006528464.1

    UniProtKB/Swiss-Prot
    Q7TPS0, Q8BWZ2, Q9CUR6
    UniProtKB/TrEMBL
    B1B0X3, E9QK39
    Conserved Domains (2) summary
    cd05582
    Location:193 → 507
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14091
    Location:542 → 828
    STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases

  5. XM_006528400.5 → XP_006528463.1  ribosomal protein S6 kinase alpha-6 isoform X1

    See identical proteins and their annotated locations for XP_006528463.1

    UniProtKB/Swiss-Prot
    Q7TPS0, Q8BWZ2, Q9CUR6
    UniProtKB/TrEMBL
    B1B0X3, E9QK39
    Conserved Domains (2) summary
    cd05582
    Location:193 → 507
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14091
    Location:542 → 828
    STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases

  6. XM_011247707.4 → XP_011246009.1  ribosomal protein S6 kinase alpha-6 isoform X6

    UniProtKB/Swiss-Prot
    Q7TPS0, Q8BWZ2, Q9CUR6
    Conserved Domains (2) summary
    cd05582
    Location:65 → 379
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14091
    Location:414 → 700
    STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases

  7. XM_030251488.2 → XP_030107348.1  ribosomal protein S6 kinase alpha-6 isoform X5

    UniProtKB/Swiss-Prot
    Q7TPS0, Q8BWZ2, Q9CUR6
    Conserved Domains (2) summary
    cd05582
    Location:114 → 428
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14091
    Location:463 → 744
    STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TPS0.2 GenPept UniProtKB/Swiss-Prot:Q7TPS0

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