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Polr3d polymerase (RNA) III (DNA directed) polypeptide D [ Mus musculus (house mouse) ]

Gene ID: 67065, updated on 5-Mar-2024

Summary

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Official Symbol
Polr3dprovided by MGI
Official Full Name
polymerase (RNA) III (DNA directed) polypeptide Dprovided by MGI
Primary source
MGI:MGI:1914315
See related
Ensembl:ENSMUSG00000000776 AllianceGenome:MGI:1914315
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RPC4; 44kDa; BN51T; TSBN51; 2810426M17Rik
Summary
Enables chromatin binding activity. Predicted to be involved in positive regulation of innate immune response and positive regulation of interferon-beta production. Predicted to act upstream of or within defense response to virus and innate immune response. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of RNA polymerase III complex. Is expressed in several structures, including 1st branchial arch; limb; nervous system; respiratory system; and sensory organ. Orthologous to human POLR3D (RNA polymerase III subunit D). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 15.9), CNS E11.5 (RPKM 14.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 D2; 14 36.32 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (70676188..70680911, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (70438748..70443471, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene piwi-like RNA-mediated gene silencing 2 Neighboring gene predicted gene, 22725 Neighboring gene predicted gene, 24890 Neighboring gene STARR-positive B cell enhancer mm9_chr14:70842927-70843227 Neighboring gene microRNA 320 Neighboring gene phytanoyl-CoA hydroxylase interacting protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A multiplicity of factors contributes to selective RNA polymerase III occupancy of a subset of RNA polymerase III genes in mouse liver. Canella D, et al. Genome Res, 2012 Apr. PMID 22287103, Free PMC Article
  2. Gene duplication and neofunctionalization: POLR3G and POLR3GL. Renaud M, et al. Genome Res, 2014 Jan. PMID 24107381, Free PMC Article
  3. PML interacts with Myc, and Myc target gene expression is altered in PML-null fibroblasts. Cairo S, et al. Oncogene, 2005 Mar 24. PMID 15735755
  4. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within defense response to virus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA transcription by RNA polymerase III IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription by RNA polymerase III IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase III complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
DNA-directed RNA polymerase III subunit RPC4
Names
BN51 (BHK21) temperature sensitivity complementing
DNA-directed RNA polymerase III subunit C4
DNA-directed RNA polymerase III subunit D
RNA polymerase III subunit C4
NP_001157554.1
NP_080221.3
XP_006519501.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164082.1 → NP_001157554.1  DNA-directed RNA polymerase III subunit RPC4

    See identical proteins and their annotated locations for NP_001157554.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC122268, AI326828, AK013165, AW491400, CA548436
    Consensus CDS
    CCDS27253.1
    UniProtKB/Swiss-Prot
    Q3U0T3, Q91WD1, Q9CZ02
    Related
    ENSMUSP00000137614.2, ENSMUST00000180358.3
    Conserved Domains (1) summary
    pfam05132
    Location:321 → 387
    RNA_pol_Rpc4; RNA polymerase III RPC4

  2. NM_025945.3 → NP_080221.3  DNA-directed RNA polymerase III subunit RPC4

    See identical proteins and their annotated locations for NP_080221.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC122268, AI326828, AK013165, AW491400, CD553533
    Consensus CDS
    CCDS27253.1
    UniProtKB/Swiss-Prot
    Q3U0T3, Q91WD1, Q9CZ02
    Related
    ENSMUSP00000000793.6, ENSMUST00000000793.13
    Conserved Domains (1) summary
    pfam05132
    Location:321 → 387
    RNA_pol_Rpc4; RNA polymerase III RPC4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    70676188..70680911 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519438.1 → XP_006519501.1  DNA-directed RNA polymerase III subunit RPC4 isoform X1

    Conserved Domains (1) summary
    pfam05132
    Location:135 → 261
    RNA_pol_Rpc4; RNA polymerase III RPC4
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91WD1.2 GenPept UniProtKB/Swiss-Prot:Q91WD1

Gene LinkOut

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