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Rbm7 RNA binding motif protein 7 [ Mus musculus (house mouse) ]

Gene ID: 67010, updated on 5-Mar-2024

Summary

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Official Symbol
Rbm7provided by MGI
Official Full Name
RNA binding motif protein 7provided by MGI
Primary source
MGI:MGI:1914260
See related
Ensembl:ENSMUSG00000042396 AllianceGenome:MGI:1914260
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1200007M24Rik; 1500011D06Rik
Summary
Predicted to enable 14-3-3 protein binding activity and RNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome and snRNA catabolic process. Predicted to act upstream of or within meiotic cell cycle. Located in nucleus. Orthologous to human RBM7 (RNA binding motif protein 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 26.0), bladder adult (RPKM 18.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A5.3; 9 26.43 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (48399997..48406630, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (48488697..48495330, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39335 Neighboring gene predicted gene, 39334 Neighboring gene STARR-seq mESC enhancer starr_24068 Neighboring gene STARR-positive B cell enhancer ABC_E3826 Neighboring gene RNA exonuclease 2 Neighboring gene STARR-positive B cell enhancer ABC_E9759 Neighboring gene predicted gene 5617 Neighboring gene STARR-seq mESC enhancer starr_24069 Neighboring gene nicotinamide N-methyltransferase Neighboring gene STARR-positive B cell enhancer ABC_E5067 Neighboring gene STARR-seq mESC enhancer starr_24071

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis. Fukushima K, et al. Immunity, 2020 Mar 17. PMID 32187520
  2. p38MAPK/MK2-mediated phosphorylation of RBM7 regulates the human nuclear exosome targeting complex. Tiedje C, et al. RNA, 2015 Feb. PMID 25525152, Free PMC Article
  3. Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs. Rousseau S, et al. EMBO J, 2002 Dec 2. PMID 12456657, Free PMC Article
  4. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables pre-mRNA intronic binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables snRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RNA-binding protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001326355.1 → NP_001313284.1  RNA-binding protein 7 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate 3' splice site, compared to variant 1, which results in a frameshift and early stop codon. It encodes isoform 2 which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA178228, AK151827, AK153504, BY087243
    UniProtKB/TrEMBL
    A0A1L1SRC3
    Conserved Domains (2) summary
    COG0724
    Location:9 → 101
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12592
    Location:9 → 83
    RRM_RBM7; RNA recognition motif in vertebrate RNA-binding protein 7 (RBM7)

  2. NM_001326356.1 → NP_001313285.1  RNA-binding protein 7 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an internal exon , compared to variant 1, which results in a frameshift and early stop codon. It encodes isoform 3 which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA178228, AI853382, AK153504, BY087243
    UniProtKB/TrEMBL
    Q3U5M9
    Conserved Domains (2) summary
    COG0724
    Location:9 → 101
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cl17169
    Location:9 → 83
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. NM_144948.5 → NP_659197.2  RNA-binding protein 7 isoform 1

    See identical proteins and their annotated locations for NP_659197.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
    Source sequence(s)
    AA178228, AK151056, BY087243
    Consensus CDS
    CCDS23155.1
    UniProtKB/Swiss-Prot
    Q3UB91, Q7TQE3, Q9CQT2
    UniProtKB/TrEMBL
    Q14A95
    Related
    ENSMUSP00000126374.3, ENSMUST00000170000.4
    Conserved Domains (2) summary
    COG0724
    Location:9 → 101
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12592
    Location:9 → 83
    RRM_RBM7; RNA recognition motif in vertebrate RNA-binding protein 7 (RBM7)

RNA

  1. NR_037589.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in the 5' coding region, compared to variant 1, which results in a frameshift and early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record, however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for non-mediated mRNA decay (NMD).
    Source sequence(s)
    AA178228, AK153504, BY087243
    Related
    ENSMUST00000214923.2

  2. NR_136937.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate exon in the 5' coding region, compared to variant 1, which results in a frameshift and early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record, however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for non-mediated mRNA decay (NMD).
    Source sequence(s)
    AA178228, AK005998, AK153504, BY087243

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    48399997..48406630 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQT2.1 GenPept UniProtKB/Swiss-Prot:Q9CQT2

Gene LinkOut

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