U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SPP1 secreted phosphoprotein 1 [ Homo sapiens (human) ]

Gene ID: 6696, updated on 22-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
SPP1provided by HGNC
Official Full Name
secreted phosphoprotein 1provided by HGNC
Primary source
HGNC:HGNC:11255
See related
Ensembl:ENSG00000118785 MIM:166490; AllianceGenome:HGNC:11255
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OPN; BNSP; BSPI; ETA-1
Summary
The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Biased expression in placenta (RPKM 1043.5), gall bladder (RPKM 1025.4) and 3 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
4q22.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (87975714..87983411)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (91302203..91309899)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (88896866..88904563)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:88813182-88814381 Neighboring gene heat shock protein 90 alpha family class B member 3, pseudogene Neighboring gene Sharpr-MPRA regulatory region 543 Neighboring gene Sharpr-MPRA regulatory region 601 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:88842859-88843386 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:88843387-88843913 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:88856983-88857804 Neighboring gene uncharacterized LOC124900730 Neighboring gene SPP1 5' regulatory region Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15559 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15560 Neighboring gene RNA, U1 small nuclear 36, pseudogene Neighboring gene polycystin 2, transient receptor potential cation channel Neighboring gene Sharpr-MPRA regulatory region 5607

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. SPP1 as a risk factor for patients with acute on chronic liver failure undergoing liver transplantation. Yu Y, et al. Int Immunopharmacol, 2023 Jul. PMID 37257271
  2. Osteopontin: A Bone-Derived Protein Involved in Rheumatoid Arthritis and Osteoarthritis Immunopathology. Martín-Márquez BT, et al. Biomolecules, 2023 Mar 9. PMID 36979437, Free PMC Article
  3. Could Osteopontin be a useful biomarker in the diagnosis and severity assessment of osteoarthritis? A systematic review and meta-analysis of recent evidence. Abdelnaby R, et al. Clin Immunol, 2023 Jan. PMID 36403917
  4. Osteopontin expression in the invasive front stroma of colorectal adenocarcinoma is associated with tumor budding and prognosis. Nakajima T, et al. Pathol Res Pract, 2022 Dec. PMID 36332325
  5. Osteopontin promotes infarct repair. Rotem I, et al. Basic Res Cardiol, 2022 Oct 14. PMID 36239866

See all (1154) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Extracellular vesicle dynamics in COPD: understanding the role of miR-422a, SPP1 and IL-17 A in smoking-related pathology.
    Title: Extracellular vesicle dynamics in COPD: understanding the role of miR-422a, SPP1 and IL-17 A in smoking-related pathology.
  2. ASSESSMENT OF OSTEOPONTIN, SCLEROSTIN, AND OSTEOCALCIN LEVELS IN PATIENTS WITH HYPOTHYROIDISM ON MEDICAL THERAPY.
    Title: ASSESSMENT OF OSTEOPONTIN, SCLEROSTIN, AND OSTEOCALCIN LEVELS IN PATIENTS WITH HYPOTHYROIDISM ON MEDICAL THERAPY.
  3. Crosstalk of platelets with macrophages and fibroblasts aggravates inflammation, aortic wall stiffening, and osteopontin release in abdominal aortic aneurysm.
    Title: Crosstalk of platelets with macrophages and fibroblasts aggravates inflammation, aortic wall stiffening, and osteopontin release in abdominal aortic aneurysm.
  4. Common Variants in Osteopontin and CD44 Genes as Predictors of Treatment Outcome in Radiotherapy and Chemoradiotherapy for Non-Small Cell Lung Cancer.
    Title: Common Variants in Osteopontin and CD44 Genes as Predictors of Treatment Outcome in Radiotherapy and Chemoradiotherapy for Non-Small Cell Lung Cancer.
  5. SPP1 is associated with adverse prognosis and predicts immunotherapy efficacy in penile cancer.
    Title: SPP1 is associated with adverse prognosis and predicts immunotherapy efficacy in penile cancer.
  6. METTL3/16-mediated m[6]A modification of ZNNT1 promotes hepatocellular carcinoma progression by activating ZNNT1/osteopontin/S100A9 positive feedback loop-mediated crosstalk between macrophages and tumour cells.
    Title: METTL3/16-mediated m(6)A modification of ZNNT1 promotes hepatocellular carcinoma progression by activating ZNNT1/osteopontin/S100A9 positive feedback loop-mediated crosstalk between macrophages and tumour cells.
  7. Osteopontin is associated with neutrophil extracellular trap formation in elderly patients with severe sepsis.
    Title: Osteopontin is associated with neutrophil extracellular trap formation in elderly patients with severe sepsis.
  8. Osteopontin, osteoprotegerin and musculoskeletal ultrasound findings in first-degree relatives of rheumatoid arthritis: potential markers of preclinical disease.
    Title: Osteopontin, osteoprotegerin and musculoskeletal ultrasound findings in first-degree relatives of rheumatoid arthritis: potential markers of preclinical disease.
  9. Osteopontin interacts with dendritic cells and macrophages in pulp inflammation: Comprehensive transcriptomic analysis and laboratory investigations.
    Title: Osteopontin interacts with dendritic cells and macrophages in pulp inflammation: Comprehensive transcriptomic analysis and laboratory investigations.
  10. Serum secreted phosphoprotein 1 level is associated with plaque vulnerability in patients with coronary artery disease.
    Title: Serum secreted phosphoprotein 1 level is associated with plaque vulnerability in patients with coronary artery disease.
Submit: New GeneRIF Correction See all GeneRIFs (1083)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
GWAS of dental caries patterns in the permanent dentition.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC110940

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
  
enables extracellular matrix binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables integrin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ion binding EXP
Inferred from Experiment
more info
 PubMed 
enables ion binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small molecule binding EXP
Inferred from Experiment
more info
 PubMed 
Process Evidence Code Pubs
involved_in androgen catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in biomineral tissue development IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to testosterone stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in decidualization TAS
Traceable Author Statement
more info
 PubMed 
involved_in embryo implantation TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of collateral sprouting of intact axon in response to injury IEA
Inferred from Electronic Annotation
more info
  
involved_in osteoblast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of bone resorption IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of estradiol secretion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to macrophage colony-stimulating factor IEA
Inferred from Electronic Annotation
more info
  
involved_in response to steroid hormone IEA
Inferred from Electronic Annotation
more info
  
involved_in response to vitamin D IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
osteopontin
Names
SPP1/CALPHA1 fusion
early T-lymphocyte activation 1
lnc-PKD2-2-3
nephropontin
osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein
secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)
urinary stone protein
uropontin

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030362.1 RefSeqGene

    Range
    5065..12762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000582.3 → NP_000573.1  osteopontin isoform OPN-b precursor

    See identical proteins and their annotated locations for NP_000573.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 5. The resulting isoform (OPN-b, as described in PubMed: 7837791) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform e.
    Source sequence(s)
    AF052124, BX648003
    Consensus CDS
    CCDS3626.1
    UniProtKB/TrEMBL
    A6XMV6
    Related
    ENSP00000237623.7, ENST00000237623.11
    Conserved Domains (1) summary
    pfam00865
    Location:21 → 300
    Osteopontin; Osteopontin

  2. NM_001040058.2 → NP_001035147.1  osteopontin isoform OPN-a precursor

    See identical proteins and their annotated locations for NP_001035147.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 5. The resulting isoform (OPN-a, as described in PubMed: 7837791) has a shorter and distinct N-terminus compared to isoform e.
    Source sequence(s)
    AA665210, BC017387, CB117856
    Consensus CDS
    CCDS43250.1
    UniProtKB/Swiss-Prot
    B2RDA1, P10451, Q15681, Q15682, Q15683, Q4W597, Q567T5, Q8NBK2, Q96IZ1
    UniProtKB/TrEMBL
    A6XMV6
    Related
    ENSP00000378517.3, ENST00000395080.8
    Conserved Domains (1) summary
    pfam00865
    Location:21 → 314
    Osteopontin

  3. NM_001040060.2 → NP_001035149.1  osteopontin isoform OPN-c precursor

    See identical proteins and their annotated locations for NP_001035149.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 5. The resulting isoform (OPN-c, as described in PubMed: 7837791) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform e.
    Source sequence(s)
    AA665210, AC131944, BC093033
    Consensus CDS
    CCDS34027.1
    UniProtKB/TrEMBL
    C4B6Q2
    Related
    ENSP00000354042.4, ENST00000360804.4
    Conserved Domains (1) summary
    pfam00865
    Location:21 → 287
    Osteopontin; Osteopontin

  4. NM_001251829.2 → NP_001238758.1  osteopontin isoform 4 precursor

    See identical proteins and their annotated locations for NP_001238758.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks two alternate in-frame exons compared to variant 5. The resulting isoform (4) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform e.
    Source sequence(s)
    AB209987, AC131944, CB117856, JF412667
    Consensus CDS
    CCDS93558.1
    UniProtKB/TrEMBL
    C4B6Q2, D6R9C5, Q3LGB0
    Related
    ENSP00000422973.2, ENST00000508233.6
    Conserved Domains (1) summary
    pfam00865
    Location:26 → 273
    Osteopontin; Osteopontin

  5. NM_001251830.2 → NP_001238759.1  osteopontin isoform 5

    See identical proteins and their annotated locations for NP_001238759.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) represents the longest transcript and encodes the longest isoform (5).
    Source sequence(s)
    AC131944, AK295491, CB117856, JF412667
    UniProtKB/TrEMBL
    A6XMV6, B7Z351
    Related
    ENST00000509659.5
    Conserved Domains (1) summary
    pfam00865
    Location:43 → 327
    Osteopontin; Osteopontin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    87975714..87983411
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    91302203..91309899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10451.1 GenPept UniProtKB/Swiss-Prot:P10451

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous