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Eif4e3 eukaryotic translation initiation factor 4E member 3 [ Mus musculus (house mouse) ]

Gene ID: 66892, updated on 11-Apr-2024

Summary

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Official Symbol
Eif4e3provided by MGI
Official Full Name
eukaryotic translation initiation factor 4E member 3provided by MGI
Primary source
MGI:MGI:1914142
See related
Ensembl:ENSMUSG00000093661 AllianceGenome:MGI:1914142
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
eIF4E-3; 1300018P11Rik
Summary
Predicted to enable RNA 7-methylguanosine cap binding activity and translation initiation factor activity. Predicted to act upstream of or within regulation of translation and translational initiation. Predicted to be part of eukaryotic translation initiation factor 4F complex. Is expressed in blood vessel; central nervous system; and sensory organ. Orthologous to human EIF4E3 (eukaryotic translation initiation factor 4E family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 17.2), subcutaneous fat pad adult (RPKM 13.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Eif4e3 in Genome Data Viewer
Location:
6 D3; 6 45.98 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (99599008..99669834, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (99621879..99692873, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene forkhead box P1 Neighboring gene STARR-seq mESC enhancer starr_16824 Neighboring gene predicted gene, 52870 Neighboring gene STARR-positive B cell enhancer mm9_chr6:99211544-99211845 Neighboring gene STARR-positive B cell enhancer mm9_chr6:99214819-99215119 Neighboring gene STARR-positive B cell enhancer ABC_E4848 Neighboring gene STARR-seq mESC enhancer starr_16826 Neighboring gene STARR-positive B cell enhancer ABC_E6458 Neighboring gene STARR-positive B cell enhancer ABC_E4849 Neighboring gene STARR-positive B cell enhancer ABC_E6459 Neighboring gene STARR-seq mESC enhancer starr_16827 Neighboring gene predicted gene, 32882 Neighboring gene STARR-seq mESC enhancer starr_16828 Neighboring gene STARR-seq mESC enhancer starr_16829 Neighboring gene STARR-seq mESC enhancer starr_16831 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:99472882-99473069 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:99473114-99473223 Neighboring gene STARR-seq mESC enhancer starr_16834 Neighboring gene STARR-seq mESC enhancer starr_16835 Neighboring gene STARR-seq mESC enhancer starr_16836 Neighboring gene STARR-positive B cell enhancer mm9_chr6:99575045-99575346 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:99608680-99608863 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:99616004-99616187 Neighboring gene predicted gene, 52869 Neighboring gene G protein-coupled receptor 27 Neighboring gene predicted gene, 26748 Neighboring gene prokineticin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. eIF4E3 acts as a tumor suppressor by utilizing an atypical mode of methyl-7-guanosine cap recognition. Osborne MJ, et al. Proc Natl Acad Sci U S A, 2013 Mar 5. PMID 23431134, Free PMC Article
  2. Characterization of mammalian eIF4E-family members. Joshi B, et al. Eur J Biochem, 2004 Jun. PMID 15153109
  3. Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Adissu HA, et al. Dis Model Mech, 2014 May. PMID 24652767, Free PMC Article
  4. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
  5. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA 7-methylguanosine cap binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of eukaryotic translation initiation factor 4F complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 4E type 3
Names
eIF-4E type 3
eIF-4E3
eIF4E type 3
eukaryotic translation initiation factor-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025829.4 → NP_080105.1  eukaryotic translation initiation factor 4E type 3

    See identical proteins and their annotated locations for NP_080105.1

    Status: PROVISIONAL

    Source sequence(s)
    AC122929, AC152987
    Consensus CDS
    CCDS20386.1
    UniProtKB/Swiss-Prot
    Q9D983, Q9DBB5
    Related
    ENSMUSP00000032151.3, ENSMUST00000032151.3
    Conserved Domains (1) summary
    pfam01652
    Location:31 → 181
    IF4E; Eukaryotic initiation factor 4E

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    99599008..99669834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255550.2 → XP_030111410.1  eukaryotic translation initiation factor 4E type 3 isoform X1

    Conserved Domains (1) summary
    pfam01652
    Location:6 → 92
    IF4E; Eukaryotic initiation factor 4E

  2. XM_030255549.2 → XP_030111409.1  eukaryotic translation initiation factor 4E type 3 isoform X1

    Conserved Domains (1) summary
    pfam01652
    Location:6 → 92
    IF4E; Eukaryotic initiation factor 4E

  3. XM_036152264.1 → XP_036008157.1  eukaryotic translation initiation factor 4E type 3 isoform X1

    Conserved Domains (1) summary
    pfam01652
    Location:6 → 92
    IF4E; Eukaryotic initiation factor 4E

  4. XM_030255548.2 → XP_030111408.1  eukaryotic translation initiation factor 4E type 3 isoform X1

    Conserved Domains (1) summary
    pfam01652
    Location:6 → 92
    IF4E; Eukaryotic initiation factor 4E
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBB5.1 GenPept UniProtKB/Swiss-Prot:Q9DBB5

Gene LinkOut

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