Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tab1provided by MGI
Official Full Name: TGF-beta activated kinase 1/MAP3K7 binding protein 1provided by MGI
Primary source: MGI:MGI:1913763
See related: Ensembl:ENSMUSG00000022414 AllianceGenome:MGI:1913763
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Map3k7ip1; b2b449Clo; 2310012M03Rik
Summary: Enables kinase activator activity. Acts upstream of or within several processes, including circulatory system development; positive regulation of MAPK cascade; and transforming growth factor beta receptor signaling pathway. Predicted to be located in nuclear speck. Predicted to be part of protein-containing complex. Predicted to be active in cytosol and nucleus. Is expressed in genitourinary system. Orthologous to human TAB1 (TGF-beta activated kinase 1 (MAP3K7) binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 16.5), ovary adult (RPKM 14.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 37.85 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (80017333..80045908)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (80133127..80161707)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1.
Title: RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1.
Exosomal miR-767 from senescent endothelial-derived accelerating skin fibroblasts aging via inhibiting TAB1.
Title: Exosomal miR-767 from senescent endothelial-derived accelerating skin fibroblasts aging via inhibiting TAB1.
TAB1 regulates glycolysis and activation of macrophages in diabetic nephropathy.
Title: TAB1 regulates glycolysis and activation of macrophages in diabetic nephropathy.
Study using knock-in mouse model elucidated the role of the p38alpha-TAB1 interaction during myocardial ischemia in vivo suggested that persistent p38alpha activation may be the result of the disinhibition of MAP2K3 access in the absence of TAB1 docking on p38alpha and proposed that TAB1 phosphorylation downstream of p38alpha is associated with cardiac damage during ischemia.
Title: The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules.
our study uncovers that RNF114-mediated ubiquitination and degradation of TAB1 activate the NF-kappaB pathway during MZT, and thus directly link maternal clearance to early embryo development.
Title: The E3 ubiquitin ligase RNF114 and TAB1 degradation are required for maternal-to-zygotic transition.
We confirmed that PGC-1b inhibited downstream inflammatory signals via binding with TAB1 and thus preventing TAB1/TAK1 binding and TAK1 activation.
Title: PGC-1β suppresses saturated fatty acid-induced macrophage inflammation by inhibiting TAK1 activation.
The E3 ubiquitin ligase Itch inhibits p38alpha signaling and skin inflammation through the ubiquitylation of Tab1.
Title: The E3 ubiquitin ligase Itch inhibits p38α signaling and skin inflammation through the ubiquitylation of Tab1.
TAB1 and TAB2 are required for activated macrophages, making TAB1 and TAB2 effective targets to control inflammation by modulating macrophage survival.
Title: Activated macrophage survival is coordinated by TAK1 binding proteins.
Both the MEKK1 PHD and TAB1 are critical for ES-cell differentiation
Title: The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines.
The enhanced JNK and IkappaB kinase activation in DUSP14-deficient T cells was attenuated by TAB1 short hairpin RNA knockdown.
Title: Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables kinase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables mitogen-activated protein kinase p38 binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within aorta development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac septum development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within coronary vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cGAS/STING signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
NOT involved_in protein dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

Names: Tak1-binding protein 1; mitogen-activated protein kinase kinase kinase 7-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025609.3 → NP_079885.2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

See identical proteins and their annotated locations for NP_079885.2

Status: VALIDATED

Source sequence(s)

BC054369, BQ176587, BY262560

Consensus CDS

CCDS27659.1

UniProtKB/Swiss-Prot

Q7TQJ5, Q80V65, Q8CF89, Q8R0D1

Related

ENSMUSP00000023050.8, ENSMUST00000023050.9

Conserved Domains (1) summary

pfam00481
Location:69 → 334

PP2C; Protein phosphatase 2C

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

80017333..80045908

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521259.4 → XP_006521322.1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1

Conserved Domains (1) summary

cl00120
Location:1 → 168

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...