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Mterf3 mitochondrial transcription termination factor 3 [ Mus musculus (house mouse) ]

Gene ID: 66410, updated on 5-Mar-2024

Summary

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Official Symbol
Mterf3provided by MGI
Official Full Name
mitochondrial transcription termination factor 3provided by MGI
Primary source
MGI:MGI:1913660
See related
Ensembl:ENSMUSG00000021519 AllianceGenome:MGI:1913660
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mterfd1; 2410017I18Rik
Summary
Predicted to enable transcription cis-regulatory region binding activity. Involved in negative regulation of transcription, DNA-templated. Located in mitochondrion. Is expressed in several structures, including early conceptus and genitourinary system. Orthologous to human MTERF3 (mitochondrial transcription termination factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 7.6), whole brain E14.5 (RPKM 7.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 B3; 13 34.54 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (67053520..67081148, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (66906577..66933083, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34888 Neighboring gene high mobility group box 2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:67006259-67006368 Neighboring gene ubiquinol-cytochrome c reductase binding protein Neighboring gene RNA guanine-7 methyltransferase activating subunit like Neighboring gene STARR-positive B cell enhancer ABC_E10799 Neighboring gene STARR-seq mESC enhancer starr_34889 Neighboring gene phosphatidylserine synthase 1 Neighboring gene RIKEN cDNA 4933433G19 gene Neighboring gene STARR-seq mESC enhancer starr_34892 Neighboring gene zinc finger protein 712 Neighboring gene STARR-positive B cell enhancer ABC_E3085

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Enhanced cardiomyocyte Ca(2+) cycling precedes terminal AV-block in mitochondrial cardiomyopathy Mterf3 KO mice. Andersson DC, et al. Antioxid Redox Signal, 2011 Nov 1. PMID 21381862
  2. Onset and organ specificity of Tk2 deficiency depends on Tk1 down-regulation and transcriptional compensation. Dorado B, et al. Hum Mol Genet, 2011 Jan 1. PMID 20940150, Free PMC Article
  3. MTERF3 is a negative regulator of mammalian mtDNA transcription. Park CB, et al. Cell, 2007 Jul 27. PMID 17662942
  4. MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates and mammals. Wredenberg A, et al. PLoS Genet, 2013. PMID 23300484, Free PMC Article
  5. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mitochondrial ribosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transcription termination factor 3, mitochondrial
Names
MTERF domain containing 1
mTERF domain-containing protein 1, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025547.4 → NP_079823.2  transcription termination factor 3, mitochondrial precursor

    See identical proteins and their annotated locations for NP_079823.2

    Status: VALIDATED

    Source sequence(s)
    AC124433
    Consensus CDS
    CCDS26611.1
    UniProtKB/Swiss-Prot
    Q8R3J4, Q9CSV1, Q9CWM7
    Related
    ENSMUSP00000021991.5, ENSMUST00000021991.11
    Conserved Domains (1) summary
    cl19765
    Location:148 → 350
    mTERF

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    67053520..67081148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517322.4 → XP_006517385.1  transcription termination factor 3, mitochondrial isoform X3

    Conserved Domains (1) summary
    cl19765
    Location:148 → 348
    mTERF

  2. XM_036158110.1 → XP_036014003.1  transcription termination factor 3, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl19765
    Location:148 → 363
    mTERF

  3. XM_011244548.4 → XP_011242850.1  transcription termination factor 3, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_011242850.1

    UniProtKB/Swiss-Prot
    Q8R3J4, Q9CSV1, Q9CWM7
    Conserved Domains (1) summary
    cl19765
    Location:148 → 350
    mTERF

  4. XM_017315563.3 → XP_017171052.1  transcription termination factor 3, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q8R3J4, Q9CSV1, Q9CWM7
    Conserved Domains (1) summary
    cl19765
    Location:148 → 350
    mTERF

  5. XM_006517321.3 → XP_006517384.1  transcription termination factor 3, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006517384.1

    UniProtKB/Swiss-Prot
    Q8R3J4, Q9CSV1, Q9CWM7
    Conserved Domains (1) summary
    cl19765
    Location:148 → 350
    mTERF

  6. XM_036158114.1 → XP_036014007.1  transcription termination factor 3, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl19765
    Location:148 → 363
    mTERF

  7. XM_036158111.1 → XP_036014004.1  transcription termination factor 3, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl19765
    Location:148 → 363
    mTERF

  8. XM_030247357.2 → XP_030103217.1  transcription termination factor 3, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q8R3J4, Q9CSV1, Q9CWM7
    Conserved Domains (1) summary
    cl19765
    Location:148 → 350
    mTERF

  9. XM_036158113.1 → XP_036014006.1  transcription termination factor 3, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl19765
    Location:148 → 363
    mTERF

  10. XM_036158112.1 → XP_036014005.1  transcription termination factor 3, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl19765
    Location:148 → 363
    mTERF

RNA

  1. XR_004938051.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R3J4.1 GenPept UniProtKB/Swiss-Prot:Q8R3J4

Gene LinkOut

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